Embryonic origin of primary colon cancer predicts survival in patients undergoing ablation for colorectal liver metastases

Yamashita, Satoshi; Odisio, Bruno C.; Huang, Steven Y.; Kopetz, Scott; Ahrar, Kamran; Chun, Yun Shin; Conrad, Claudius; Aloia, Thomas A.; Gupta, Sanjay; Harmoush, S.; Hicks, Marshall E.; Vauthey, Jean‐Nicolas

doi:10.1016/j.ejso.2017.01.007

Cited by 18 publications

(18 citation statements)

References 30 publications

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“…In addition, several prognostic factors of poor OS were identified: a tumor diameter > 3 cm, tumor location in the right colon, multiple tumors, extrahepatic metastases pre-RFA, and intrahepatic recurrence. These concur with previously reported prognostic factors (6,13,(41)(42)(43), except for intrahepatic recurrence; this may be the reason that these investigators did not conduct further analysis into the relationship between intrahepatic recurrence and OS. However, intrahepatic recurrence may indicate the presence of more tumor cells in the blood, resulting in poor OS.…”

Section: Discussionsupporting

confidence: 91%

Ten-Year Outcomes of Percutaneous Radiofrequency Ablation for Colorectal Cancer Liver Metastases in Perivascular vs. Non-Perivascular Locations: A Propensity-Score Matched Study

et al. 2020

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Purpose: To compare long-term outcomes of percutaneous radiofrequency ablation for colorectal liver metastases in perivascular versus non-perivascular locations. Methods: This retrospective study included 388 consecutive patients with colorectal liver metastases (246 men, 142 women; age range 27-86 years) who underwent percutaneous radiofrequency ablation between January 2006 and December 2018. Propensity-score matching was performed for groups with perivascular and nonperivascular colorectal liver metastases. Rates of accumulative local tumor progression, overall survival, intra/extrahepatic recurrence, and complications were compared between the two groups. Results: We successfully matched 104 patients each in the perivascular and nonperivascular groups (mean age: 60.

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Section: Discussionsupporting

confidence: 91%

Ten-Year Outcomes of Percutaneous Radiofrequency Ablation for Colorectal Cancer Liver Metastases in Perivascular vs. Non-Perivascular Locations: A Propensity-Score Matched Study

et al. 2020

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“…In colonic adenocarcinoma, an increasing number of studies have shown that tumors located in the left‐sided colon and the right‐sided colon, which originate from the hindgut and midgut, respectively, share different molecular features, characteristics, and prognoses as well as different responses to certain kinds of therapy, such as chemotherapy and EGFR antibody therapy . However, a comparison of colonic NENs originating from the midgut and hindgut has not been reported .…”

Section: Discussionmentioning

confidence: 99%

“…AJCC, American Joint Committee on Cancer; ENETS, European Neuroendocrine Tumor Society; NET, neuroendocrine tumor; SEER, Surveillance, Epidemiology, and End Results Time (years) A 21 18 13 11 4 2 5 4 3 3 3 2 7 6 2 IV to certain kinds of therapy, such as chemotherapy and EGFR antibody therapy. [17][18][19][20] However, a comparison of colonic NENs originating from the midgut and hindgut has not been reported. 12,21 Our study was the first to suggest that the two sites of colonic NENs were indeed different.…”

Section: Discussionmentioning

confidence: 99%

“…Since the biological behavior of colonic adenocarcinoma located in the left-sided colon and the right-sided colon, which originate from the hindgut and midgut, respectively, are significantly distinct, [17][18][19][20] we further compared the clinical features of colonic NENs between the midgut and hindgut ( Table 2). In the Chinese cohort, 158 out of 167 patients in the cohort were included for analyses, since the tumor origin of nine patients was unknown.…”

Section: Comparison Of the Clinical Features Of Colonic Nens In Thementioning

confidence: 99%

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Clinicopathological features and prognostic validity of the European Neuroendocrine Tumor Society (ENETS) and American Joint Committee on Cancer (AJCC) 8th staging systems in colonic neuroendocrine neoplasms

et al. 2019

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Purpose This study aimed to investigate the characteristics of colonic neuroendocrine neoplasms (NENs) and to validate the prognostic value of the European Neuroendocrine Tumor Society (ENETS) and American Joint Committee on Cancer (AJCC) 8th staging systems. Methods A total of 167 and 1248 patients with colonic NENs from 12 medical centers across China and from the Surveillance, Epidemiology, and End Results (SEER) cancer registry in the United States, respectively, were reviewed. Patients were staged according to the ENETS and AJCC 8th staging systems. Results Clinicopathological features of colonic NENs in the Chinese cohort and SEER cohort were significantly distinct. In both the Chinese cohort and the SEER cohort, colonic neuroendocrine carcinoma (NEC) and mixed adeno‐neuroendocrine carcinoma (MANEC) were more frequent in the midgut than in the hindgut. Tumors originating from the midgut tended to be larger and at a more advanced stage than those from the hindgut. The AJCC 8th staging system and the ENETS system appeared to have similar prognostic ability for colonic NEC/MANEC. Conclusions Our study revealed that tumors originating from the midgut and the hindgut shared different clinicopathological features. The AJCC 8th staging system and the ENETS system appeared to have similar prognostic ability for colonic NEC/MANEC.

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“…These parts of the colon then differ in mucosal immunology and in gut microbiota. A higher density of eosinophilic leukocytes and intraepithelial T-cells has been shown in the proximal colon (17,18). Tumours from both parts of the colon are further distinguished by certain clinicopathological properties that can influence the long-term survival of patients, both after resection of primary tumour and after operations for CLMs (19,20).…”

Section: Discussionmentioning

confidence: 99%

Long-term Results of Surgery for Colorectal Liver Metastases in Terms of Primary Tumour Location and Clinical Risk Factors

Třeška¹,

Skála²,

Procházková³

et al. 2020

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Background/Aim: The aim of the study was to evaluate the influence of primary tumour location and clinical risk factors for long-term results of surgery for colorectal liver metastases (CLMs). Patients and Methods: Overall survival (OS) and recurrence-free survival (RFS) were evaluated in 636 patients. Patients were divided by tumour location (right-/left-sided colorectal cancer: RCRC/LCRC; rectal cancer), and age, gender, number and size of CLMs, type of liver surgery and interval from primary operation were evaluated. Results: One-, 3-and 5-year OS and RFS were independent of primary tumour location (p<0.59). CLM diameter was negatively associated with OS for the whole cohort (p<0.002), and RCRC (p<0.03) and LCRC (p<0.04) groups, as well as for RFS of those with LCRC (p<0.04). CLM number was negatively associated with RFS for the whole cohort (p<0.0001), RCRC (p<0.02), LCRC (p<0.0001) and RC (p<0.02). Radiofrequency ablation and combined procedures led to worse OS for the whole cohort (p<0.03), and to worse RFS for the whole cohort (p<0.0003) and for those with LCRC (p<0.03). A shorter interval between primary colorectal cancer surgery and CLMs procedure was risky for poor OS and RFS of patients with CLMs from RCRC (p<0.05), LCRC (p<0.05) and RC (p<0.02). Conclusion: Primary tumour location together with clinical risk factors are important for longterm results of surgery CLMs.

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Embryonic origin of primary colon cancer predicts survival in patients undergoing ablation for colorectal liver metastases

Cited by 18 publications

References 30 publications

Ten-Year Outcomes of Percutaneous Radiofrequency Ablation for Colorectal Cancer Liver Metastases in Perivascular vs. Non-Perivascular Locations: A Propensity-Score Matched Study

Ten-Year Outcomes of Percutaneous Radiofrequency Ablation for Colorectal Cancer Liver Metastases in Perivascular vs. Non-Perivascular Locations: A Propensity-Score Matched Study

Clinicopathological features and prognostic validity of the European Neuroendocrine Tumor Society (ENETS) and American Joint Committee on Cancer (AJCC) 8th staging systems in colonic neuroendocrine neoplasms

Long-term Results of Surgery for Colorectal Liver Metastases in Terms of Primary Tumour Location and Clinical Risk Factors

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