“…Both occur most frequently in children; both have a similar naked eye appearance and both, as well as showing evidence of differentiation into striated muscle, often contain areas which resemble primitive mesenchyme. Most authors, e.g., Willis (1953Willis ( , 1958, Prior and Stoner (1957) and Holborow and White (1958) now consider that these rhabdomyosarcomas belong to a group of tumours, sometimes referred to as "embryonic sarcomas" (White, 1952) that consist basically of immature mesenchyme which exhibits a variable degree of differentiation into striated muscle and fibrous tissue. The Rhabdomyosarcomas which we have been discussing, therefore, probably arise, not from adult muscle, but from embryonic mesenchyme.…”