Embryonic Stem Cells

Klimanskaya, Irina; Kimbrel, Erin A.; Lanza, Robert

doi:10.1016/b978-0-12-398358-9.00029-x

Cited by 4 publications

(2 citation statements)

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“…Human ESCs are derived from the inner cell mass and contribute to multiple types of cells in the body [ 98 ]. Although many factors have been reported to maintain hESC populations, including bFGF [ 82 , 99 ], TGF-β1 [ 83 , 100 ], activin A [ 101 ], neurotrophins [ 102 ], Wnt/β-catenin signaling [ 86 ] and sphingosine-1-phosphate (S1P) [ 103 ], knowledge on the receptor activation required for the self-renewal of hESCs is limited.…”

Section: Activation Of Igf/igf-1r Signaling Improves Stem Cell-based ...mentioning

confidence: 99%

Mini Review: Molecular Interpretation of the IGF/IGF-1R Axis in Cancer Treatment and Stem Cells-Based Therapy in Regenerative Medicine

Lin

Lin²,

Lee

et al. 2022

IJMS

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In addition to the fundamental role of insulin-like growth factor (IGF)/IGF-1 receptor (IGF-1R) signaling dysregulation in cancer initiation and proliferation, the IGF/IGF-1R signaling also plays an important role in the maintenance of stem cell characteristics and enhancement of stem cell-based therapeutic efficacy. This review focused on the role of IGF/IGF-1R signaling in preclinical IGF-targeted therapies, including IGF-1R monoclonal antibodies, IGF-1R tyrosine kinase inhibitors, and neutralizing antibodies of IGFs in multiple tumors and endocrine disorders. On the other hand, the function of IGF/IGF-1R signaling in stem cell self-renewal, pluripotency and therapeutic efficacy in regenerative medicine was outlined. Finally, the review summarized ongoing studies on IGF/IGF-1R signaling blockade in multiple cancers and highlighted the IGF-1R signaling modifications in stem cells as a potential strategy to improve stem cell-based therapeutics in regenerative medicine.

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Section: Activation Of Igf/igf-1r Signaling Improves Stem Cell-based ...mentioning

confidence: 99%

Mini Review: Molecular Interpretation of the IGF/IGF-1R Axis in Cancer Treatment and Stem Cells-Based Therapy in Regenerative Medicine

Lin

Lin²,

Lee

et al. 2022

IJMS

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“…Embryonic stem (ES) cells are considered as immortal version of the ICM in culture; they retain high telomerase activity and can continue to self-renew indefinitely under appropriate culture conditions. When injected into immune-deficient mice, hESC form teratoma tumors that contain derivatives of all three germ layers, the most typical ones being bone, cartilage, neural rosettes and epithelium of the airways and gut (Klimanskaya et al 2014). Yamanaka et al discover that Induced pluripotent stem cells (iPS) is an effort to make a mature cell into pluripotent cell (Takahashi and Yamanaka 2006).…”

Section: The Cellsmentioning

confidence: 99%

Tissue Bank and Tissue Engineering

Mahyudin

Suroto

2016

Advanced Structured Materials

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Permanent damage on the tissue or organ are still a major problem and chalenge to be solved in the world of medicine. Humankind has tried to solve the problem using technologies available in their respective era since long time ago. We can read from various literature about the efforts already made to replace and consequently heal the damaged tissue or organ. Tissue or organ damage caused by war and many other causes became the main reason of the tissue bank's estabilishment in many parts of the earth. Tissue bank strife to provide safe and high quality products to be used as natural biomaterial for damaged tissue reconstruction in patients. Several processes started from procurement, processing, and finally sterilization has been done to guarantee safe and useful products for the patients in need. In line with the recent technological advancement, especially with the introduction of stem cell usage, tissue and organ reconstruction has entered a new era that will bring greater hope for patients. If the previous methods that used biomaterial only employ dead tissue in the reconstruction procedures, tissue engineering will make the combination between stem cell and biomaterial as scaffold possible, thus enabling the living tissue to be used in reconstruction. This method, albeit still in the process of research, is expected to yield better results.

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