Embryotoxic action of methyl mercury on coho salmon embryos

Devlin, E. W.; Mottet, N. Karle

doi:10.1007/bf01239651

Cited by 11 publications

(11 citation statements)

References 9 publications

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“…The authors observed many other teratogenic and mutagenic effects of mercury-severe gross malformation of the craniofacial, cardiovascular and skeletal systems. Mercury also disturbed the development of Oncorhynchus kisutch embryos (Devlin and Mottel 1992). They showed vacuolization and enlargement of the spinal cord cells and swelling of skeletal muscles.…”

Section: Embryonic Body Malformationsmentioning

confidence: 97%

The effects of heavy metals on embryonic development of fish (a review)

Jezierska¹,

Ługowska²,

Witeska³

2008

Fish Physiol Biochem

398

179

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Early developmental stages of fish are particularly sensitive to water pollution. Heavy metals may affect various developmental processes during the embryonic period, which results in a reduction of offspring quantity and quality. Waterborne metals may accumulate in the gonads of spawners and adversely affect gamete production and viability, or exert direct toxic influence upon developing embryos. The egg shell does not fully protect the embryo against metal penetration, particularly during the swelling phase; thus, metals may accumulate in the egg. The results depend on metal concentration and range from developmental disturbances to death of the embryo. Metals disturb various processes of fish embryonic development and affect the development rate. Early stages just after fertilization are particularly sensitive to metal intoxication, when most disturbances and the highest embryonic mortality occur. Waterborne metals also promote developmental anomalies during organogenesis, including body malformations. Heavy metals often induce a delay in the hatching process, premature hatching, deformations and death of newly hatched larvae. All these disturbances result in reduced numbers and poor quality of the larvae, which show small body size, high frequency of malformations and reduced viability.

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Section: Embryonic Body Malformationsmentioning

confidence: 97%

The effects of heavy metals on embryonic development of fish (a review)

Jezierska¹,

Ługowska²,

Witeska³

2008

Fish Physiol Biochem

398

179

View full text Add to dashboard Cite

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“…The 221-39 lg/l LC50 values of MeHg to fathead minnow embryos reported in the current study are similar to LC50 values reported for embryos of other fish species. For example, LC50 values of 55 lg/l MeHg in the medaka (Oryzias latipes) (Sakaizumi, 1980), 51 lg/l MeHg and 67 lg/l HgCl 2 in the killifish (Fundulus heteroclitus) Neff, 1982, 1980), 47-70 lg/l MeHg in coho salmon (Oncorhynchus kisutch) (Devlin and Mottet, 1992), 54-71 lg/l MeHg in rainbow trout (Salmo gairdneri) (Devlin and Mottet, 1991), 50 lg/l HgCl 2 in carp (Cyprinus carpio), 100 lg/l HgCl 2 in carp hawk fish Cirrhinus mrigala (Shrivastava et al, 1988), and 430 lg/ 1 MeHg in larval catfish (Clarias batrachus) (Kirubagaran and Joy, 1988) have been reported. It is of interest that the range of LC50 values is similar in both the smaller, faster-developing cyprinids and the larger, slower-developing salmonids.…”

Section: Acute Toxicitymentioning

confidence: 99%

“…Embryos and early larval stages have been shown to be especially sensitive indicators of a number of types of aquatic pollution (Devlin and Mottet, 1992;Pickering and Lazorchak, 1995). Exposure of fish embryos to low concentrations of pollutants, like MeHg, often have significant effects on the biology and behavior of later developmental stages (Fjeld et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Acute Toxicity, Uptake and Histopathology of Aqueous Methyl Mercury to Fathead Minnow Embryos

Devlin

2006

Ecotoxicology

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Early life stages of fishes have been shown to be especially susceptible to the toxic effects of heavy metal pollution. In this study, fathead minnow (Pimephales promelas) embryos were exposed in the laboratory to a graded series of aqueous methyl mercury concentrations under continuous-flow conditions. A number of toxicological endpoints were examined including; acute toxicity, bioaccumulation, protein production, impact on mitosis, gross and histopathology. Acute toxicity, reported as LC50 values of methyl mercury, ranged from 221 microg/l (95% C.I. 246-196 microg/l) for 24-h tests to 39 microg/l (95% C.I. 54-24 microg/l) for 96-h exposures. Fathead minnow embryos were shown to rapidly take up mercury from the surrounding water. Mercury levels in embryos reached levels of 2.80 microg/g wet weight after 96 h exposure to 40 microg/l methyl mercury. An initial elevation of total protein in embryo was observed in embryos exposed to 25 microg/l methyl mercury during the first 12 h of development. At later stages, significantly lower levels of protein/microg embryo were observed. Methyl mercury had no effect on mitotic stages (p=0.05) in early, cleaving blastula-stage embryos. Live embryos and serial sections were utilized to characterize changes in embryo morphology and histopathology.

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“…High concentrations of mercury have also been shown to affect other aspects of teleost reproduction. Developmental abnormalities have been observed in a variety of teleost species, including Oncorhynchus kisutch (53-120 µg Hg/l) (Devlin and Mottet 1992), Salvelinus fontinalis (0.93-2.9 µg Hg/l) (McKim et al 1976), and Fundulus heteroclitus (20-40 µg Hg/l) (Weis and Weis 1977). Kirubaragaran et al (1992) reported retardation of gamete maturation in C. batrachus (32-37 µg Hg/l), and Bano and Hasan (1990) and Wester and Canton (1992) described inhibition of oogenesis in Heteropneustes fossilis (148 µg Hg/l) and spermatogenesis in Poecilia reticulata (4.5-8.0 µg Hg/l), respectively.…”

Section: Fishmentioning

confidence: 99%

“…Most laboratory investigations into the effect of mercury on fish populations employ concentrations and methods of exposure that are not environmentally relevant. Studies designed to elucidate the influence of mercury on teleost reproduction, an important determinant of fish populations, have exposed fish primarily to water-borne mercury concentrations in the µg/l range (McKim et al 1976;Weis and Weis 1977;Snarski and Olson 1982;Joy 1988, 1992;Dey and Bhattacharya 1989;Bano and Hasan 1990;Dave and Xiu 1991;Devlin and Mottet 1992;Wester and Canton 1992). In contrast, mercury levels in natural waters of North America rarely exceed the ng/l range (Wiener and Spry 1995).…”

mentioning

confidence: 99%