Embryotoxicity and teratogenicity study with neohesperidin dihydrochalcone in rats

Waalkens-Berendsen, D.H.; Kuilman-Wahls, Mariella E.M.; Bär, A.

doi:10.1016/j.yrtph.2004.05.007

Cited by 24 publications

(25 citation statements)

References 24 publications

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“…There have been no reports concerning the concentration level of naringenin or quercetin in embryos or fetuses after the dam exposure, or whether they have the ability to cross the placental barrier. In this sense, only few flavonoids have been studied, such as the synthetic flavonoid (3‐methyl‐48,6‐dihydroxy‐38, 58‐diiodoflavone), [33] α ‐naphthoflavone, [34] catechin [35] and epigallactocatechin gallate and neohesperidin dihydrochalcone, the placental‐barrier‐crossing capacity of which has been quantified, but no teratogenic potential has been evaluated [36] . On the contrary placental and fetal tissue levels of genistein [37] and daidzein, [38] which are teratogenic flavonoids because of their phytoestrogenic activity, have been measured, but their toxic effect depends on oestrogen receptor occupancy in the placenta rather than on their ability to cross the placenta or their conceptus concentration level.…”

Section: Discussionmentioning

confidence: 99%

Quercetin and naringenin reduce abnormal development of mouse embryos produced by hydroxyurea

Pérez-Pasten¹,

Martínez-Galero²,

Chamorro-Cevallos³

2010

Journal of Pharmacy and Pharmacology

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Section: Discussionmentioning

confidence: 99%

Quercetin and naringenin reduce abnormal development of mouse embryos produced by hydroxyurea

Pérez-Pasten¹,

Martínez-Galero²,

Chamorro-Cevallos³

2010

Journal of Pharmacy and Pharmacology

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“…There were 45 articles 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 reporting 47 studies examining changes in BW following at least daily compulsory consumption of LES (details in Supplementary Table S1 ). LES were either added to the animals' only source of food or water, or were orally intubated daily.…”

Section: Animal Studiesmentioning

confidence: 99%

Does low-energy sweetener consumption affect energy intake and body weight? A systematic review, including meta-analyses, of the evidence from human and animal studies

et al. 2015

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By reducing energy density, low-energy sweeteners (LES) might be expected to reduce energy intake (EI) and body weight (BW). To assess the totality of the evidence testing the null hypothesis that LES exposure (versus sugars or unsweetened alternatives) has no effect on EI or BW, we conducted a systematic review of relevant studies in animals and humans consuming LES with ad libitum access to food energy. In 62 of 90 animal studies exposure to LES did not affect or decreased BW. Of 28 reporting increased BW, 19 compared LES with glucose exposure using a specific ‘learning' paradigm. Twelve prospective cohort studies in humans reported inconsistent associations between LES use and body mass index (−0.002 kg m−2 per year, 95% confidence interval (CI) −0.009 to 0.005). Meta-analysis of short-term randomized controlled trials (129 comparisons) showed reduced total EI for LES versus sugar-sweetened food or beverage consumption before an ad libitum meal (−94 kcal, 95% CI −122 to −66), with no difference versus water (−2 kcal, 95% CI −30 to 26). This was consistent with EI results from sustained intervention randomized controlled trials (10 comparisons). Meta-analysis of sustained intervention randomized controlled trials (4 weeks to 40 months) showed that consumption of LES versus sugar led to relatively reduced BW (nine comparisons; −1.35 kg, 95% CI –2.28 to −0.42), and a similar relative reduction in BW versus water (three comparisons; −1.24 kg, 95% CI –2.22 to −0.26). Most animal studies did not mimic LES consumption by humans, and reverse causation may influence the results of prospective cohort studies. The preponderance of evidence from all human randomized controlled trials indicates that LES do not increase EI or BW, whether compared with caloric or non-caloric (for example, water) control conditions. Overall, the balance of evidence indicates that use of LES in place of sugar, in children and adults, leads to reduced EI and BW, and possibly also when compared with water.

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“…Developmental and reproductive toxicity studies have been considered by SCF in the report on neohesperidin dihydrochalcone .061] (SCF,1989) and are summarised in the Annex IV, Table IV.3. Since the report by SCF was published, one further study on developmental/reproductive toxicity has become available (Waalkens-Berendsen et al, 2004). In this study embryotoxicity and teratogenicity were examined by feeding neohesperidin dihydrochalcone at dairy concentrations of 0, 1.25, 2.50 or 5.0 % corresponding to 0, 0.8-0.9, 1.6-1.7 and 3.1-3.4 g/kg bw/day, respectively, to groups of mated female rats from day 0 to 21 of gestation.…”

Section: Developmental / Reproductive Toxicity Studiesmentioning

confidence: 99%

Flavouring Group Evaluation 32 (FGE.32): Flavonoids (Flavanones and dihydrochalcones) from chemical groups 25 and 30

Flavourings¹

2010

EFSA Journal

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Embryotoxicity and teratogenicity study with neohesperidin dihydrochalcone in rats

Cited by 24 publications

References 24 publications

Quercetin and naringenin reduce abnormal development of mouse embryos produced by hydroxyurea

Quercetin and naringenin reduce abnormal development of mouse embryos produced by hydroxyurea

Does low-energy sweetener consumption affect energy intake and body weight? A systematic review, including meta-analyses, of the evidence from human and animal studies

Flavouring Group Evaluation 32 (FGE.32): Flavonoids (Flavanones and dihydrochalcones) from chemical groups 25 and 30

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