Emergence and Reemergence of Severe Acute Respiratory Syndrome (SARS) Coronaviruses

Baxi, Preeti; Saxena, Shailendra K.

doi:10.1007/978-981-15-4814-7_13

Cited by 8 publications

(10 citation statements)

References 32 publications

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“…4,10 Thus, the lungs, immune organs, and systemic small vessels are the main targets of virus attack, so that extensive consolidation of the lung, diffuse alveolar damage with hyaline membrane formation, respiratory distress, and decreased immune function are the main causes of death. 4,10,11 On the other hand, present study showed that sepsis occurred in nearly 25% of adults due to viral infection which results in alveolar and acute respiratory failure. 12 Thus, some studies show that the main causes of death are related to SARS and sepsis, but the evolution of pulmonary and systemic inflammation in the first and/or second week may determine outcome of disease (death or survival).…”

Section: Discussionmentioning

confidence: 61%

Epidemiological profile of COVID-19 deaths in the public hospital in Rio de Janeiro, Brazil

Maior¹,

Assef²,

Campos³

et al. 2020

IJCAM

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The aim of this study was to describe the epidemiological profiles of the Covid-19 deaths in the public reference hospital Ronaldo Gazolla Hospital ranging from their age, sex, race, cause of death and length of stay until death. Retrospective descriptive observational study with patients who died with a positive COVID-19 diagnosis who presented themselves to this center during the outbreak of April 2020. Our sample included 261 deaths and information reported includes age, sex, and race, cause of death and length of stay until death. All cases were confirmed by diagnostic outcomes, using nasopharyngeal swab samples were collected for extracting 2019-nCoV RNA through the technique of real-time reverse transcription polymerase chain reaction (RT-PCR). Our sample was comprised of 62.1% men, with a mean age of 60.1 (SD=16.1) years. A proportion of 43.3% (n=113) of the patients were brown, 16.9% (n=42) were black and 40.6% (n=106) were white. The median of duration of hospital stay was 3.8days (1.6; 6.5). Most deaths were caused by severe acute respiratory syndrome (62.1%), followed by sepsis (24.1%). This study showed that most COVID-19 deaths at the public reference hospital occurred due to severe acute respiratory syndrome (SARS), with a higher proportion of men, brown race and an average age of 60years. The short time of hospital stay between hospitalization and death draws attention to the deficiency of the public health system of Rio de Janeiro city.

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Section: Discussionmentioning

confidence: 61%

Epidemiological profile of COVID-19 deaths in the public hospital in Rio de Janeiro, Brazil

Maior¹,

Assef²,

Campos³

et al. 2020

IJCAM

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“…Thus, recombination among several SARS-CoV-2 variants could occur under suitable conditions favoring the emergence of new strains. The antigenic divergence of SARS-CoV-2 characterized by new glycosylation sites may have contributed to this virus generating the COVID-19 pandemic [74].…”

Section: Antigenic Changes In Sars-cov-2mentioning

confidence: 99%

Implications of the Immune Polymorphisms of the Host and the Genetic Variability of SARS-CoV-2 in the Development of COVID-19

Zepeda–Cervantes

Martínez-Flores

Ramírez-Jarquín

et al. 2022

Viruses

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The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the current pandemic affecting almost all countries in the world. SARS-CoV-2 is the agent responsible for coronavirus disease 19 (COVID-19), which has claimed millions of lives around the world. In most patients, SARS-CoV-2 infection does not cause clinical signs. However, some infected people develop symptoms, which include loss of smell or taste, fever, dry cough, headache, severe pneumonia, as well as coagulation disorders. The aim of this work is to report genetic factors of SARS-CoV-2 and host-associated to severe COVID-19, placing special emphasis on the viral entry and molecules of the immune system involved with viral infection. Besides this, we analyze SARS-CoV-2 variants and their structural characteristics related to the binding to polymorphic angiotensin-converting enzyme type 2 (ACE2). Additionally, we also review other polymorphisms as well as some epigenetic factors involved in the immunopathogenesis of COVID-19. These factors and viral variability could explain the increment of infection rate and/or in the development of severe COVID-19.

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“…The first complete genome sequence of the SARS-CoV-2 isolated from human cases from China was reported on January 05, 2020 by China ( Wu et al, 2020b ) and currently, thousands of genomes sequences have been reported till date. The various scientific investigations has reported that both times COVID-19 patients were infected with the viruses had differences in some of their genes caused by antigenic drift, antigenic shift, and recombination known as natural mutations ( Baxi and Saxena, 2020 ). The Hong Kong case provides the first documentary evidence and confirmed that different viral strains are responsible for reinfection ( To et al, 2020 ).…”

Section: Reinfection and Genome Sequencementioning

confidence: 99%

Coronavirus reinfections: An outlook on evidences and effects

Patel

Shirbhate

Rajak

2022

Lessons From COVID-19

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Emergence and Reemergence of Severe Acute Respiratory Syndrome (SARS) Coronaviruses

Abstract: The positive-strand RNA viruses, severe acute respiratory syndrome coronavirus (SARS-CoV) and recently emerged COVID-19 epidemics, demonstrated the transmission capability of the coronaviruses by crossing the species barrier and emergence in humans.

Cited by 8 publications

References 32 publications

Epidemiological profile of COVID-19 deaths in the public hospital in Rio de Janeiro, Brazil

Epidemiological profile of COVID-19 deaths in the public hospital in Rio de Janeiro, Brazil

Implications of the Immune Polymorphisms of the Host and the Genetic Variability of SARS-CoV-2 in the Development of COVID-19

Coronavirus reinfections: An outlook on evidences and effects

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