Emergence in Britain of Beta-Lactamase-Producing Gonococci With New Plasmid Combination

Johnston, Neil; Kolator, B

doi:10.1016/s0140-6736(82)91641-5

Cited by 17 publications

(4 citation statements)

References 5 publications

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“…Since then further reports have confirmed that genetic interchange between gonococci is occur ring. [14][15][16] In this study seven PPNG strains were isolated, one of which showed the African P-lactamase type with the additional conjugative plasmid. The plasmid analysis is shown in table II together with the MICs to ampicillin, sulbactam, and the combination (sultamicillin).…”

Section: Discussionmentioning

confidence: 96%

Sultamicillin in the treatment of gonorrhoea caused by penicillin sensitive and penicillinase producing strains of Neisseria gonorrhoeae.

Atia¹,

Emmerson²,

Holmes³

1983

Sexually Transmitted Infections

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SUMMARY A single oral dose of 2 g of sultamicillin and 1 g of probenecid was effective in the treatment of men with uncomplicated gonococcal urethritis caused by both penicillin sensitive strains of Neisseria gonorrhoeae and penicillinase producing strains of N gonorrhoeae (PPNG). Of 94 infected men who attended for at least one follow up examination, 91 (970o) were cured. The remaining three (3Wo) patients were still infected at follow up. Two of these patients had been re-exposed to an infected partner and were considered to be possible reinfections, while the third was deemed a treatment failure. Six of the 94 patients were infected with PPNG strains and all were successfully treated. Plasmid analysis of the PPNG strains showed Asian and African types both with and without transfer plasmid.

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Section: Discussionmentioning

confidence: 96%

Sultamicillin in the treatment of gonorrhoea caused by penicillin sensitive and penicillinase producing strains of Neisseria gonorrhoeae.

Atia¹,

Emmerson²,

Holmes³

1983

Sexually Transmitted Infections

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“…These findings are in accord with previous findings (1,13,17,22,24) that PPNG strains harboring the Far East type R plasmid also frequently carry the 24.5 Md transfer plasmid. In contrast, most of the PPNG strains harboring the 3.2 Md West Africa type R plasmid do not harbor the conjugative plasmid (16), although in recent years, more and more of these PPNG strains have been shown to carry this large transfer plasmid (1,5,9,23).…”

Section: Discussionmentioning

confidence: 99%

Plasmid Profiles of Neisseria gonorrhoeae in Peninsular Malaysia

Kalaimathee

Koh

Ngeow

1985

Microbiology and Immunology

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The plasmid profiles of 160 strains of Neisseria gonorrhoeae isolated in Peninsular Malaysia, comprising 80 penicillinase-producing (PPNG) and 80 nonpenicillinase-producing (non-PPNG) isolates, were determined. The 80 PPNG isolates were divided into two plasmid groups. All of them harbored two common plasmid species, a 4.4 megadalton (Md) R plasmid previously associated with p-lactamase production in PPNG strains from the Far East and a 2.6 Md multicopy plasmid of unknown function. In addition to these two plasmids, 60 (75%) PPNG isolates also carried a large 24.5 Md conjugative plasmid.In contrast, the 80 non-PPNG strains were divided into three plasmid groups. All of them possessed the 2.6 Md cryptic plasmid, and 35 (44%) isolates also harbored the 24.5 Md transfer plasmid. Besides these two plasmids, one non-PPNG isolate carried an additional 7.8 Md cryptic plasmid.

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“…Two cases of combined "African" and transfer plasmids were recently reported from Great Britain. 13 The combination of Asian plasmids with transfer plasmids is the rule in Great Britain and elsewhere, however,12 13 but has not led to disproportionately rapid spread of the Asian plasmid here.…”

Section: Geographical Origins Of Strains Imported Into Great Britainmentioning

confidence: 98%

Penicillinase-producing Neisseria gonorrhoeae in Great Britain, 1977-81: alarming increase in incidence and recent development of endemic transmission.

McCutchan¹,

Adler²,

Berrie³

1982

BMJ

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Emergence in Britain of Beta-Lactamase-Producing Gonococci With New Plasmid Combination

Cited by 17 publications

References 5 publications

Sultamicillin in the treatment of gonorrhoea caused by penicillin sensitive and penicillinase producing strains of Neisseria gonorrhoeae.

Sultamicillin in the treatment of gonorrhoea caused by penicillin sensitive and penicillinase producing strains of Neisseria gonorrhoeae.

Plasmid Profiles of Neisseria gonorrhoeae in Peninsular Malaysia

Penicillinase-producing Neisseria gonorrhoeae in Great Britain, 1977-81: alarming increase in incidence and recent development of endemic transmission.

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