Emergence in Italy of
            <i>Klebsiella pneumoniae</i>
            Sequence Type 258 Producing KPC-3 Carbapenemase

Giani, Tommaso; D’Andrea, Marco Maria; Pecile, Patrizia; Borgianni, Luisa; Nicoletti, P.; Tonelli, Francesco; Bartoloni, Alessandro; Rossolini, Gian María

doi:10.1128/jcm.01773-09

Cited by 105 publications

(74 citation statements)

References 10 publications

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“…Since then, KPC-producing bacteria have been isolated in most places around the world, including South America, Europe and Asia. In many countries such as Greece, Israel, Poland and Italy [15][16][17] , KPCs have become endemic but in other cases they remain a rare infection cause. Infections caused by KPCs include life-threatening infections such as bacteremia and pneumonia in critically ill patients.…”

Section: K Pneumoniaementioning

confidence: 99%

Association between infections caused by multidrug-resistant gram-negative bacteria and mortality in critically ill patients

Paramythiotou

Routsi

2016

WJCCM

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The incidence of gram-negative multidrug-resistant (MDR) bacterial pathogens is increasing in hospitals and particularly in the intensive care unit (ICU) setting. The clinical consequences of infections caused by MDR pathogens remain controversial. The purpose of this review is to summarize the available data concerning the impact of these infections on mortality in ICU patients. Twenty-four studies, conducted exclusively in ICU patients, were identified through PubMed search over the years 2000-2015. Bloodstream infection was the only infection examined in eight studies, respiratory infections in four and variable infections in others. Comparative data on the appropriateness of empirical antibiotic treatment were provided by only seven studies. In ten studies the presence of antimicrobial resistance was not associated with increased mortality; on the contrary, in other studies a significant impact of antibiotic resistance on mortality was found, though, sometimes, mediated by inappropriate antimicrobial treatment. Therefore, a direct association between infections due to gram-negative MDR bacteria and mortality in ICU patients cannot be confirmed. Sample size, presence of multiple confounders and other methodological issues may influence the results. These data support the need for further studies to elucidate the real impact of infections caused by resistant bacteria in ICU patients.

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Section: K Pneumoniaementioning

confidence: 99%

Association between infections caused by multidrug-resistant gram-negative bacteria and mortality in critically ill patients

Paramythiotou

Routsi

2016

WJCCM

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“…Diversos reportes evidencian la existencia de clones internacionales o epidémicos de K. pneumoniae en todo el mundo (5,14,30,31); y algunas investigaciones han revelado la existencia de clones identificados por genotipos asociados con infecciones específicas (31). Por lo tanto, es necesario realizar una vigilancia activa de este patógeno, especialmente en países donde este problema aun no es bien investigado.…”

Section: Discussionunclassified

Caracterización molecular de cepas de Klebsiella pneumoniae productoras de BLEE causantes de infección intrahospitalaria en el servicio de neonatología de un hospital de Lima, Perú

Bailón

Sacsaquispe

2013

Rev Med Hered

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“…pneumonia [1,4,5]. Many cases and outbreaks of CRE in other countries have been attributed to patient transfers from Italy [6,9].…”

Section: Outbreak and Epidemiologymentioning

confidence: 99%

“…A north-south gradient can be seen with KPC-KP being endemic in Italy, Greece and Israel [1]. A recent survey from Italy reported several hospital outbreaks and countrywide dissemination of KPC-KP [4,5]. In many European countries with low KPC prevalence, outbreaks have been linked to patients transferred from endemic regions [1,6].…”

Section: Introductionmentioning

confidence: 99%

First documented outbreak of KPC-2-producing Klebsiella pneumoniae in Switzerland: infection control measures and clinical management

et al. 2014

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We report the epidemiological and clinical features of the first outbreak of Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-KP) type 2 in Switzerland. The outbreak took place in the medical intensive care unit (MICU) of our tertiary care hospital and affected three severely ill patients. After the implementation of strict infection control measures, no further patients colonised with KPC-KP could be detected by the screening of exposed patients. Successful treatment of patients infected with KPC-KP consisted of a combination therapy of meropenem, colistin and tigecycline. EL and PK contributed equally to the work. All authors have seen and approved the manuscript.The manuscript has not been published and is not being considered for publication elsewhere. Correspondence and request for reprints to:Eva Lemmenmeier

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Emergence in Italy of Klebsiella pneumoniae Sequence Type 258 Producing KPC-3 Carbapenemase

Cited by 105 publications

References 10 publications

Association between infections caused by multidrug-resistant gram-negative bacteria and mortality in critically ill patients

Association between infections caused by multidrug-resistant gram-negative bacteria and mortality in critically ill patients

Caracterización molecular de cepas de Klebsiella pneumoniae productoras de BLEE causantes de infección intrahospitalaria en el servicio de neonatología de un hospital de Lima, Perú

First documented outbreak of KPC-2-producing Klebsiella pneumoniae in Switzerland: infection control measures and clinical management

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