Emergence in the central nervous system

Brown, Steven R.

doi:10.1007/s11571-012-9229-6

Cited by 17 publications

(5 citation statements)

References 276 publications

(209 reference statements)

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“…So far, the origin of cognitive deficits of TLE still remains unknown. Theoretically, many factors may affect cognitive ability, including seizures themselves (Marques et al 2007), interictal epileptiform discharges (Aldenkamp and Arends 2004), and the reorganization of the underlying neuronal circuitry (Morimoto et al 2004;Seth 2008;Brown 2013). Although antiepileptic drugs can relieve epileptic seizures, some studies have revealed that these drugs also have some adverse effects on cognition (Meador 2006).…”

Section: Introductionmentioning

confidence: 99%

Exposure to Mozart music reduces cognitive impairment in pilocarpine-induced status epilepticus rats

et al. 2015

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Patients with temporal lobe epilepsy (TLE) often display cognitive deficits. However, current epilepsy therapeutic interventions mainly aim at how to reduce the frequency and degree of epileptic seizures. Recovery of cognitive impairment is not attended enough, resulting in the lack of effective approaches in this respect. In the pilocarpine-induced temporal lobe epilepsy rat model, memory impairment has been classically reported. Here we evaluated spatial cognition changes at different epileptogenesis stages in rats of this model and explored the effects of long-term Mozart music exposure on the recovery of cognitive ability. Our results showed that pilocarpine rats suffered persisting cognitive impairment during epileptogenesis. Interestingly, we found that Mozart music exposure can significantly enhance cognitive ability in epileptic rats, and music intervention may be more effective for improving cognitive function during the early stages after Status epilepticus. These findings strongly suggest that Mozart music may help to promote the recovery of cognitive damage due to seizure activities, which provides a novel intervention strategy to diminish cognitive deficits in TLE patients.

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Section: Introductionmentioning

confidence: 99%

Exposure to Mozart music reduces cognitive impairment in pilocarpine-induced status epilepticus rats

et al. 2015

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“…Although the melatonin receptor has been observed in the hippocampus [23,24,27], NAS has also been detected in this region [5]. There are reports on the connections between antidepressants, such as fluoxetine, and NAS in synaptic plasticity and neurogenesis.…”

Section: Discussionmentioning

confidence: 99%

“…There are several reports about the effects of melatonin on neurogenesis in the dentate gyrus, but no study has been conducted on the effects of NAS on cell proliferation and neuroblast differentiation, even though NAS is widely distributed within the brainstem, cerebellum, and hippocampus [5], unlike melatonin. In this study, we investigated the effects of NAS on cell proliferation and neuroblast differentiation using Ki67 and DCX antibodies, respectively, in C57BL/6J mice, which are animals that synthesize melatonin and have plasma levels lower than other strains of mice [13,29].…”

mentioning

confidence: 99%

N-Acetylserotonin Increases Cell Proliferation and Differentiating Neuroblasts with Tertiary Dendrites through Upregulation of Brain-Derived Neurotrophic Factor in the Mouse Dentate Gyrus

et al. 2011

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ABSTRACT. In this study, we investigated the effects of N-acetylserotonin (NAS) on cell proliferation and neuroblast differentiation in the mouse dentate gyrus using anti-Ki67 and anti-doublecortin (DCX) antibodies. Ki67 is expressed in the nucleus or on the surface of chromosomes during all of the active phases of the cell cycle, and DCX is expressed in neuronal precursor cells as well as in immature neurons. At 17 weeks of age, 20 mg/kg of NAS or the same volume of vehicle was intraperitoneally administered once a day for 3 weeks. The animals were sacrificed 2 hr after the last vehicle or NAS treatment. NAS treatment significantly increased the number of Ki67-positive nuclei and DCX-immunoreactive neuroblasts with well-developed dendrites (tertiary dendrites) compared to the vehicle-treated group. However, the number of DCX-immunoreactive neuroblasts without tertiary dendrites was not changed. The administration of NAS also significantly increased the protein levels of brain-derived neurotrophic factor (BDNF) in the dentate gyrus. This result suggests that NAS significantly promotes cell proliferation and the number of differentiating neuroblasts with tertiary dendrites through an increase in BDNF levels in the mouse dentate gyrus.KEY WORDS: brain-derived neurotrophic factor, cell proliferation, dentate gyrus, N-acetylserotonin, neuroblast differentiation.

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“…The cognitive performance of individuals can be compared to the performance of models of Artificial Intelligence (AI) (Newell and Simon 1972) and neurocomputational models (Arbib 2003;Brown 2013; É rdi 2015). These performance comparisons provide ways to channel subjective experiences into objects that can be tested by scientific methods.…”

Section: Neural Codes For Knowledge and Understandingmentioning

confidence: 99%

The feeling of understanding: an exploration with neural models

Mizraji

Lin

2016

Cogn Neurodyn

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There exists a dynamic interaction between the world of information and the world of concepts, which is seen as a quintessential byproduct of the cultural evolution of individuals as well as of human communities. The feeling of understanding (FU) is that subjective experience that encompasses all the emotional and intellectual processes we undergo in the process of gathering evidence to achieve an understanding of an event. This experience is part of every person that has dedicated substantial efforts in scientific areas under constant research progress. The FU may have an initial growth followed by a quasi-stable regime and a possible decay when accumulated data exceeds the capacity of an individual to integrate them into an appropriate conceptual scheme. We propose a neural representation of FU based on the postulate that all cognitive activities are mapped onto dynamic neural vectors. Two models are presented that incorporate the mutual interactions among data and concepts. The first one shows how in the short time scale, FU can rise, reach a temporary steady state and subsequently decline. The second model, operating over longer scales of time, shows how a reorganization and compactification of data into global categories initiated by conceptual syntheses can yield random cycles of growth, decline and recovery of FU.

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Emergence in the central nervous system

Cited by 17 publications

References 276 publications

Exposure to Mozart music reduces cognitive impairment in pilocarpine-induced status epilepticus rats

Exposure to Mozart music reduces cognitive impairment in pilocarpine-induced status epilepticus rats

N-Acetylserotonin Increases Cell Proliferation and Differentiating Neuroblasts with Tertiary Dendrites through Upregulation of Brain-Derived Neurotrophic Factor in the Mouse Dentate Gyrus

The feeling of understanding: an exploration with neural models

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