2021
DOI: 10.1007/s41061-021-00350-w
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Emergence of 2-Pyrone and Its Derivatives, from Synthesis to Biological Perspective: An Overview and Current Status

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Cited by 18 publications
(11 citation statements)
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“…2-Pyrones are a unique class of heterocycle, and they were presented as an essential fragment in various natural products with reported biological activities ranging from antiviral, [6] antiinflammatory, [7] antitumor, [8,9] antibacterial, [10,11] to antifungal [12] properties. Of particular interest to our prime concerns with the NPs occurring 2-pyrone motif is pogostone (Figure 1) since it has been demonstrated to exhibit prominent antifungal activities.…”
Section: Introductionmentioning
confidence: 99%
“…2-Pyrones are a unique class of heterocycle, and they were presented as an essential fragment in various natural products with reported biological activities ranging from antiviral, [6] antiinflammatory, [7] antitumor, [8,9] antibacterial, [10,11] to antifungal [12] properties. Of particular interest to our prime concerns with the NPs occurring 2-pyrone motif is pogostone (Figure 1) since it has been demonstrated to exhibit prominent antifungal activities.…”
Section: Introductionmentioning
confidence: 99%
“…2-Pyrones are a class of important heterocycles that form the core of many natural products and biologically active compounds (Scheme 1a). 1 Additionally, 2-pyrones can also serve as versatile synthons in organic synthesis (Scheme 1b). 2 Due to the biological and synthetic utility of 2-pyrones, much effort has been directed toward the preparation of diversely functionalized 2-pyrones and many sophisticated works have been reported.…”
Section: Introductionmentioning
confidence: 99%
“…Pyranone is a common chemical skeleton that widely exists in natural products. Pyranone derivatives have significant applications in the fields of medicine and pesticides due to their biological activities (Figure a). , For example, tipranavir is an antiviral drug for the treatment of HIV-I, which can inhibit the enzyme activity of HIV-I protease and block the dimerization of the protease subunits. The antibiotic (−)-pironetin has been widely used in agriculture as an antilodging agent for crops, which has growth activity on plants .…”
Section: Introductionmentioning
confidence: 99%