Emergence of an Extensive Drug Resistant Pseudomonas aeruginosa Strain of Chicken Origin Carrying bla _IMP-45 , tet (X6), and tmexCD3 - toprJ3 on an Inc _pRBL16 Plasmid

Abstract

Pseudomonas aeruginosa is an opportunistic pathogen that causes infections that are difficult to treat. This study reported, for the first time, the occurrence of last-resort antibiotic resistance determinants bla IMP-45 , tet (X6), and tmexCD3 - toprJ3 on a single plasmid in P. aeruginosa from chickens.

Characterization of a mobilizable megaplasmid carrying multiple resistance genes from a clinical isolate of Pseudomonas aeruginosa

“…Compared to other plasmids carrying the genes tmexCD-oprJ , bla DIM , and qnrVC6 , such as the plasmids containing DIM, including the first one discovered in Pseudomonas stutzeri in 2007 and one found to carry the DIM-1 variant DIM-2 in Pseudomonas putida in 2013, these plasmids have not been successfully transferred to the recipient strains. Similarly, the IncpRBL16 plasmid carrying tmexCD3-toprJ3 found in P. aeruginosa could not conjugate transfer successfully (Dong et al, 2022 ). The plasmid pBM413 carrying qnrVC 6 was preliminarily determined immobile due to its lack of genes encoding relaxase and T4SS.…”