Emergence of antibiotic resistance in bacteria isolated from tubotympanic type of chronic suppurative otitis media in Chhattisgarh

Abstract

<p class="abstract"><strong>Background:</strong> Chronic suppurative otitis media (CSOM) is a common chronic ear disease and a major health problem in developing countries causing deafness and life threatening complications like meningitis and brain abscess. Early and effective treatment based on the knowledge of causative organism and their antibiotic sensitivity is essential for immediate clinical recovery.</p><p class="abstract"><strong>Methods:</strong> Total of 152 clinically diagnosed patients with CSOM safe were enrolled in the study and two swab of the discharge ear were obtained from each patient under aseptic precaution. Microbiological study was done according to standard operative guidelines. </p><p class="abstract"><strong>Results:</strong> Out of 152 patients 93 male and 59 were female, majority of the patient seen below 30 year of age. Most common organism found was <em>Staphylococcus aureus </em>(43.2%) and <em>Pseudomonas aeruginosa </em>(27.9%). <em>Staphylococcus aureus</em> was sensitive to vancomycin (98%) and linezolide (100%) and <em>Pseudomonas aeruginosa </em>was found highly sensitive to Imipenem cilastin (84.85%) and Imipenem (66.7%).</p><p class="abstract"><strong>Conclusions:</strong> In our study gram positive <em>Staphylococcus aureus</em> (43.2%) and gram negative bacilli <em>P. aeuroginosa</em> (27.9%) was the most common organism was found and this <em>P. aeruginosa</em> were hospital acquired infections. We found out high resistant to Cefepime, ceftazidime, ciprofloxacin and levofloxacin and aztreonam.</p>

Detection of FOX-AmpC-β-lactamase gene and antibiogram of AmpC-beta-lactamase-producing pathogens isolated from chronic suppurative otitis media patients in Nigeria

“…As evidenced in this study, CSOM was more common with microbial proliferation in age group of 1–10 years (30.9%) and the age group of 41 years and above. Bacterial pathogens prevalence patterns in CSOM patients within the age group of 1–10 years have been reported in previous studies ( 4 , 24 – 26 ); with the burden of disease greatest between 6 months and 18 months of age. In contrast to our study, other studies reported maximum number of CSOM cases in the first (1–10 years) and second decades (11–20 years) of life ( 24 , 27 ).…”

“…Bacterial pathogens prevalence patterns in CSOM patients within the age group of 1–10 years have been reported in previous studies ( 4 , 24 – 26 ); with the burden of disease greatest between 6 months and 18 months of age. In contrast to our study, other studies reported maximum number of CSOM cases in the first (1–10 years) and second decades (11–20 years) of life ( 24 , 27 ). Poor hygiene and unorthodox treatment approaches by care-givers, such as the use of unconventional ear drops and concoctions (oil and honey) into the middle-ear, especially in Nigeria, may initiate the proliferation of opportunistic pathogens, thereby leading to blockage of eustachian tubes in children.…”

“…Gram-negative bacteria in CSOM patients were more frequent in males than females in this study. Males have also been reported to have a higher risk factor than females for the development and acquisition of otitis media ( 24 , 25 ). The reason for this observation is still unknown.…”