Emergence of antibiotic-resistant bacterial strains,                     methicillin-resistant Staphylococcus aureus, extended spectrum                     beta lactamases, and multi-drug resistance is a problem similar to global                     warming

Bhattacharya, Pranab Kumar

doi:10.1590/0037-8682-0139-2014

Cited by 12 publications

(2 citation statements)

References 5 publications

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“…Regarding the PE-E, it was not active against any of the bacteria tested (MIC values > 1000 µg/mL, data not shown). Food-borne illnesses associated with Gram-positive bacteria, including the S. aureus enterotoxigenic strains, are a major public health issue worldwide [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

UHPLC-MS Metabolome Fingerprinting: The Isolation of Main Compounds and Antioxidant Activity of the Andean Species Tetraglochin ameghinoi (Speg.) Speg.

et al. 2018

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The seriated extracts of petroleum ether (PE-E), dichloromethane (DCM-E) and methanol extracts (MeOH-E) from the aerial parts of the native South American plant Tetraglochin ameghinoi (Rosaceae), were evaluated regarding their antioxidant and antibacterial activities. The antioxidant properties were evaluated by free radical scavenging methods (DPPH and TEAC), ferric-reducing antioxidant power (FRAP) and lipoperoxidation in erythrocytes (LP), while the antibacterial activity was performed against Gram-positive and Gram-negative bacteria according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. The chemical and biological analyses of this plant are very important since this bush is currently used in traditional medicine as a cholagogue and digestive. The polar MeOH-E showed the highest antioxidant activities (17.70 µg/mL in the DPPH assay, 381.43 ± 22.38 mM TE/g extract in the FRAP assay, 387.76 ± 91.93 mg TE/g extract in the TEAC assay and 93.23 + 6.77% in the LP assay) and it was selected for chromatographic isolation of its components. These components were found to be four acetophenones, including the new phloracetophenone glucoside: 4′,6′,-dihydroxy-2′-O-(6″-acetyl)-β-d-glucopyranosylacetophenone or IUPAC name: (6-(2-acetyl-3,5-dihydroxyphenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)methyl acetate, whose structure was elucidated by NMR and MS methods. In addition, twenty-six compounds, including five of these acetophenone derivatives, two sugars, six flavonoids, eleven phenolic acids and two triterpenes, were identified based on UHPLC-OT-MS and PDA analysis on the MeOH-E. The results support the medicinal use of the plant.

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Section: Resultsmentioning

confidence: 99%

UHPLC-MS Metabolome Fingerprinting: The Isolation of Main Compounds and Antioxidant Activity of the Andean Species Tetraglochin ameghinoi (Speg.) Speg.

et al. 2018

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“…Many antibiotic groups that bacteria were resisted such as βlactams, aminoglycosides, ulfonamides, and fluoroquinolones (Huai et al, 2019). Some of the most lifethreatening antibiotic-resistant bacterial strains with severe human implications worldwide are Pseudomonas aeruginosa, Acinetobacter baumannii (Abadi et al, 2019), Klebsiella pneumonia, Escherichia coli (Gregova and Kmet, 2 0 2 0 ) , Staphylococcus aureus (MRSA) (Bhattacharya, 2014), non-typhoidal Salmonella, Mycobacterium tuberculosis (Prestinaci et al, 2015), Stenotrophomonas maltophilia (Çıkman et al, 2016), Enterococcus faecalis (Miller et al, 2 0 1 4 ) , Proteus mirabilis (Tumbarello et al, 2012), and Burkholderia pseudomallei (Bugrysheva et al, 2017). The finding for new drug sources to treat disease infected by antibiotic-resistant bacteria is required.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activity of Cathormion umbellatum

Rattanasuk

Boongapim

Phiwthong

2021

Bangladesh J Pharmacol

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The aim of this study was to determine the antibacterial activity of Cathormion umbellatum extracts against seven antibiotic-resistant bacteria. The pods, leaves and branches of C. umbellatum were extracted with ethanol and methanol. The disc diffusion assay was used to screen the antibacterial activity and broth microdilution and colorimetric assay were used to measure the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values. The result indicated that the highest inhibition zone (11 mm) was presented in ethanolic pods extract against multidrug resistance Klebsiella pneumoniae. The lowest MIC value of 0.05 mg/mL was obtained from branch extracted with ethanol against colistin resistant Pseudomonas aeruginosa. The lowest MBC values of 1.56 mg/mL were obtained when using C. umbellatum leaves extracted with methanol against all test antibiotic-resistant bacteria. This is the first report presented C. umbellatum extracts have the potential to eliminate antibiotic-resistant bacteria in patients. These findings show the antibacterial effect of C. umbellatum.

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