2018
DOI: 10.1128/aac.02264-17
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Emergence of Azole-Resistant Aspergillus fumigatus from Immunocompromised Hosts in India

Abstract: This prospective study shows that the rate of azole-resistant (ARAF) in an immunocompromised Indian patient population with invasive aspergillosis (IA) is low, 6/706 (0.8%). This low rate supports the continued use of voriconazole as the first line of treatment. However, the ARAF isolates from India in this study exhibited three kinds of unreported mutations, of which two were at hot spots, G54R and P216L, while one was at codon Y431C.

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Cited by 19 publications
(18 citation statements)
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“…2016 , Wiederhold et al. 2016 , Dabas et al. 2018 , Tsuchido et al.…”
Section: The Worldwide Clinical Burden Of Arafmentioning
confidence: 99%
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“…2016 , Wiederhold et al. 2016 , Dabas et al. 2018 , Tsuchido et al.…”
Section: The Worldwide Clinical Burden Of Arafmentioning
confidence: 99%
“…2006 , 2009 , Albarrag et al. 2011 , Dabas et al. 2018 ) 0.5–4 0.06–2 >8–16 ND ND ND ND ND China (2011–2014; 1), France (2006–2009; 1) G432A/S (2) ( Alanio et al.…”
Section: The Worldwide Clinical Burden Of Arafmentioning
confidence: 99%
See 1 more Smart Citation
“…A previous homology model proved the interaction of P216L with POS but not with VRC, indicating that mutations in this region might play a role in POS resistance [ 49 ]. A. fumigatus strains with P216L mutation are resistant to itraconazole and posaconazole but not to voriconazole [ 50 , 51 ]. This peculiar azole susceptibility pattern is similar to the azole susceptibility phenotype exhibited by our A. flavus isolate which carries a P214L alteration.…”
Section: Discussionmentioning
confidence: 99%
“…The centre studied the epidemiology of candidemia, azole resistant A. fumigatus, and molecular identification and resistance with Trichophyton species (Dabas et al, 2017;Dabas et al, 2018)…”
Section: All India Institute Of Medical Science New Delhimentioning
confidence: 99%