Emergence of blaVIM-2, blaNDM-1, blaIMP-7 and blaGES-1 in blaKPC-2-harbouring Pseudomonas aeruginosa isolates in Brazil

Scavuzzi, Alexsandra Maria Lima; Beltrão, Elizabeth Maria Bispo; Firmo, Elza Ferreira; Oliveira, Érica Maria de; Beserra, Fernanda Gomes; Lópes, Ana Catarina de Souza

doi:10.1016/j.jgar.2019.09.009

Cited by 12 publications

(10 citation statements)

References 3 publications

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“…Different enzymes may be related to the development of resistance among CRPA isolates, in this study, a high occurrence of the blaKPC gene was found among the analyzed isolates, data that corroborate the results obtained in other studies (Jacomé et al 2016, Scavuzzi et al 2019.…”

Section: Discussionsupporting

confidence: 92%

Analyses of the response of carbapenem-resistant Pseudomonas aeruginosa against monotherapy and combined therapy using quantum dots and proteomics

Lima

Pereira

Raposo

et al. 2021

An. Acad. Bras. Ciênc.

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Section: Discussionsupporting

confidence: 92%

Analyses of the response of carbapenem-resistant Pseudomonas aeruginosa against monotherapy and combined therapy using quantum dots and proteomics

Lima

Pereira

Raposo

et al. 2021

An. Acad. Bras. Ciênc.

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“…After this stage, 13 studies met the inclusion criteria and moved on to the next stage where the articles were read in full, as can be seen in the flowchart, Figure 1. Table 1 presents the main results found in these studies [30][31][32][33][34][35][36][37][38][39][40] .…”

Section: Resultsmentioning

confidence: 99%

Occurrence of blaKPC gene in clinical isolates of Pseudomonas aeruginosa from Brazil

2022

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Pseudomonas aeruginosa is one of the main microorganisms causing healthcare-related infections. The rise of carbapenem-resistant P. aeruginosa (CRPA) strains has become a serious public health problem. Dissemination of the enzyme Klebsiella pneumoniae carbapenemase (KPC) encoded by the blaKPC gene cause the inactivation of β-lactam antibiotics being one of the mechanisms involved in this resistance. Given the above, the objective of this review was to evaluate the occurrence of the blaKPC gene in clinical isolates of P. aeruginosa in Brazil. For this, the online databases used were: Lilacs, SciELO and PubMed. The search for articles included articles published from 2012 to 2020, using the following keywords: blaKPC (KPC), Pseudomonas aeruginosa, and Brazil (in Portuguese and English). Initially, 30 publications eligible for inclusion in this review were identified. After the first analysis, two articles were excluded due to duplication. Subsequently, titles and abstracts were evaluated, 15 articles were excluded because they did not fit the theme, and 13 articles that met the inclusion criteria were read in full. In these studies, the presence of the blaKPC gene was investigated in 566 clinical isolates of P. aeruginosa in Brazil, with 86 (15.2%) positive samples found. Pernambuco was the state with the highest number of articles and positive samples, respectively, 38.5% (5/13), and 65.1% (56/86). This study reinforces the need to investigate the occurrence of this gene in all regions of the country in CRPA, aiming to understand how its dissemination occurs and to promote prevention and therapeutic strategies.

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“…Brazil also has proven to be an important ally in the detection of MDR/XDR CR-MβL-PA strains, as highlighted by data from the present study, in which IMP-, VIM-, and SPM-producing isolates have been mostly detected [ 17 , 78 , 79 , 80 ]. Worryingly, there is a recent report of CR-PA harboring the bla NDM-1 gene along with other MβL [ 29 ]. Indeed, the occurrence of isolates with the co-production of MBLs has been verified, as reported in some studies included in this meta-analysis [ 31 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

The Prevalence of Metallo-Beta-Lactamese-(MβL)-Producing Pseudomonas aeruginosa Isolates in Brazil: A Systematic Review and Meta-Analysis

Dos Santos,

Silva,

Gouveia

et al. 2023

Microorganisms

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The purpose of the current study is to describe the prevalence of Pseudomonas aeruginosa (PA)-producing MβL among Brazilian isolates and the frequency of blaSPM-1 in MβL-PA-producing isolates. From January 2009 to August 2023, we carried out an investigation on this subject in the internet databases SciELO, PubMed, Science Direct, and LILACS. A total of 20 papers that met the eligibility requirements were chosen by comprehensive meta-analysis software v2.2 for data retrieval and analysis by one meta-analysis using a fixed-effects model for the two investigations. The prevalence of MβL-producing P. aeruginosa was 35.8% or 0.358 (95% CI = 0.324–0.393). The studies’ differences were significantly different from one another (x2 = 243.15; p < 0.001; I2 = 92.18%), so they were divided into subgroups based on Brazilian regions. There was indication of asymmetry in the meta-analyses’ publishing bias funnel plot; so, a meta-regression was conducted by the study’s publication year. According to the findings of Begg’s test, no discernible publishing bias was found. blaSPM-1 prevalence was estimated at 66.9% or 0.669 in MβL-PA isolates (95% CI = 0.593–0.738). The analysis of this one showed an average heterogeneity (x2 = 90.93; p < 0.001; I2 = 80.20%). According to the results of Begg’s test and a funnel plot, no discernible publishing bias was found. The research showed that MβL-P. aeruginosa and SPM-1 isolates were relatively common among individuals in Brazil. P. aeruginosa and other opportunistic bacteria are spreading quickly and causing severe infections, so efforts are needed to pinpoint risk factors, reservoirs, transmission pathways, and the origin of infection.

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Emergence of blaVIM-2, blaNDM-1, blaIMP-7 and blaGES-1 in blaKPC-2-harbouring Pseudomonas aeruginosa isolates in Brazil

Cited by 12 publications

References 3 publications

Analyses of the response of carbapenem-resistant Pseudomonas aeruginosa against monotherapy and combined therapy using quantum dots and proteomics

Analyses of the response of carbapenem-resistant Pseudomonas aeruginosa against monotherapy and combined therapy using quantum dots and proteomics

Occurrence of blaKPC gene in clinical isolates of Pseudomonas aeruginosa from Brazil

The Prevalence of Metallo-Beta-Lactamese-(MβL)-Producing Pseudomonas aeruginosa Isolates in Brazil: A Systematic Review and Meta-Analysis

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