Emergence of canine distemper virus strains with two amino acid substitutions in the haemagglutinin protein, detected from vaccinated carnivores in North-Eastern China in 2012–2013

Pathogenesis of canine distemper virus in experimentally infected raccoon dogs, foxes, and minks

“…Possible explanation we might search in the fact that strain LN(10)1 was isolated from a fox and host adaptation could have decreased/altered the ability of our virus to replicate and induce disease in minks. This is consistent with punctuate amino acid mutations in key proteins regulating CDV host species range, like the interaction between the H protein and SLAM receptor binding sites, which mediate viral entry and exit from the host cell (McCarthy et al, 2007;Origgi et al, 2012;Nikolin et al, 2012a;Zhao et al, 2014).…”

Cross-species transmission of canine distemper virus—an update

“…Raccoon dogs are highly susceptible to CDV infection [65] showing similar morphological changes as infected domestic dogs including interstitial pneumonia, demyelinating encephalitis, lymphoid depletion in various lymphoid tissues and catarrhal or necrotizing gastroenteritis [66]. The emergence of CDV strains belonging to the Asia-1 genotype with two amino acid substitutions in the H protein isolated from raccoon dogs and other carnivores in China resulted in clinical distemper even in vaccinated animals [67].…”

Cloning and expression of mink (Neovison vison) interferon-γ gene and development of an antiviral assay

“…Mink (Neovison vison) is one of the major fur animals and its health problems have become an important issue for fur industry. The infection by canine distemper virus, parvovirus and Aleutian mink disease virus among minks has caused serious economic losses to the fur animal industry Zhao et al, 2014). Currently, there is no effective treatment for mink viral disease due to the rare cross protective effect of IFN-γ among different mammalian species (Waldvogel et al, 2004).…”