EMERGENCE OF CARBAPENEM RESISTANCE AMONG EXTENDED SPECTRUM BETA-LACTAMASE ISOLATE OF Escherichia coli FROM CLINICAL SPECIMENS IN A TERTIARY HOSPITAL, NIGERIA

Akujobi, C.N.; Ezeanya, C.C.

doi:10.9735/0975-5276.5.2.367-370

Cited by 8 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Seventeen genes were detected in animals, 28 in humans, and 12 in the environment. These genes belong to the AmpC, 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 extended-spectrum, 10 , 11 , 12 , 13 , 14 , 15 , 17 , 19 , 20 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 narrow-spectrum, 13 , 14 , 15 , 16 , 19 , 24 , …”

Section: Resultsmentioning

confidence: 99%

Beta-lactamase resistance genes in Enterobacteriaceae from Nigeria

et al. 2022

View full text Add to dashboard Cite

Background: Beta-lactamase genes are one of the most important groups of antimicrobial resistance genes in human and animal health. Therefore, continuous surveillance of this group of resistance genes is needed for a better understanding of the local epidemiology within a country and global dissemination.Aim: This review was carried out to identify different beta-lactamase resistance genes reported in published literature from Nigeria.Methods: Systematic review and meta-analysis was carried out on eligible Nigerian articles retrieved from electronic literature searches of PubMed ® , African Journals Online, and Google Scholar published between January 1990 and December 2019. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses method was adopted to facilitate clarity and transparency in reporting review findings.Results: Fifty-seven articles were included. All beta-lactamases reported were detected from Gram-negative bacteria, particularly from Enterobacteriaceae. Thirty-six different betalactamase genes were reported in Nigeria. These genes belong to the narrow-spectrum, AmpC, extended-spectrum and carbapenemase beta-lactamase resistance genes. The pooled proportion estimate of extended-spectrum beta-lactamase genes in Nigeria was 31% (95% confidence interval [CI]: 26% -36%, p < 0.0001), while the estimate of the bla CTX-M-15 gene in Nigeria was 46% (95% CI: 36% -57%, p < 0.0001). The proportion estimate of AmpC genes was 32% (95% CI: 11% -52%, p < 0.001), while the estimate for carbapenemases was 8% (95% CI: 5% -12%, p < 0.001). Conclusion:This study provides information on beta-lactamase distribution in Nigeria. This is necessary for a better understanding of molecular epidemiology of clinically important beta-lactamases, especially the extended-spectrum beta-lactamases and carbapenemases in Nigeria.

show abstract

Section: Resultsmentioning

confidence: 99%

Beta-lactamase resistance genes in Enterobacteriaceae from Nigeria

et al. 2022

View full text Add to dashboard Cite

show abstract

“…By reducing adhesion to cells, the production of organic acids antagonize pathogenic bacteria. Many probiotics produce antibacterial substances such as short chain fatty acids, hydrogen peroxide, nitric oxide, and bacteriocins that improve their ability to compete with other intestinal bacteria and most relevant pathogenic bacteria [37]. Moreover, the production of antibacterial agents is considered an important factor in the transformation of bacteria and effectiveness of probiotic bacteria [38], as the product of bacteriocin bacteria is important for the selection of probiotic bacteria.…”

Section: Role Of Probiotics In Combating Antimicrobial Resistancementioning

confidence: 99%

Probiotics: Current Trend in Combating Antimicrobial Resistance

Ezeanya-Bakpa,

Omorinbola

2024

Int J Health Sci Res

View full text Add to dashboard Cite

Probiotics are live bacteria, most commonly belonging to the Lactobacillus and Bifidobacterium genera, although strains of other species are also commercially available and beneficial to the host. From an antibiotic perspective, probiotics have been shown to reduce the risk of certain infections, such as certain types of gastro-intestinal, respiratory and other reproductive infections. This may be accompanied by a reduced need for antibiotics for secondary infections. Although antibiotics appear to be effective against most infections, resistance is increasing among bacteria. Probiotics are specifically selected to prevent cross-contamination or transmission of antibiotic resistance. It is recommended to use probiotics together with antibiotics to reduce incidence, duration and/or severity of antibiotic resistance. This provides better compatibility with antibiotics and thus reduces the development of resistance. The extent to which probiotics directly reduce the spread of antibiotics resistance has not yet been fully studied. However, maintaining the balance of the microbiome while using antibiotics has been the potential to reduce infection and consequently resistance. Probiotics may reduce the need for antibiotics thus the risk of infection. Key words: Probiotics, Antibiotic-resistant bacteria, Methicillin-resistant Staphylococcus aureus, Lactobacillus, Antimicrobial resistance

show abstract

“…For case, billions of minuscule "nanowhiskers," each about 10 nanometres in length, have been molecularly snared onto normal and manufactured strands to give recolor resistance to clothing and other textures; zinc oxide nanocrystals have been utilized to form undetectable sunscreens that square bright light; and silver nanocrystals have been implanted in gauzes to murder microbes and avoid contaminations Possibilities for long-standing time are various. Nanotechnology may make it conceivable to fabricate lighter, more grounded, and programmable materials that require less vitality to deliver than customary materials, that deliver less squander than with ordinary fabricating, which guarantee more prominent fuel productivity in arrive transportation, ships, flying machine, and space vehicles [42]. Nanocoatings for both murky and translucent surfaces may render them safe to erosion, scratches, and radiation.…”

Section: Gold Nanoparticlesmentioning

confidence: 99%

Nanotechnology: Current trends in detections of microbial pathogens

Maria Adewole

2023

Int. J. Sci. Res. Arch.

View full text Add to dashboard Cite

The circulation of pathogens in developing countries is one of the major causes of infectious disease outbreaks. Currently, there are limitations to already existing methods for microbial pathogen detection. A significant number of pathogens are left undetected via of conventional methods. The detection methods that are innovative, rapid with high sensitivity and specificity are required to target pathogens. This will aid to overcome present drawbacks in disease management. Nanotechnology is a recent advancements leading to the development of nanoparticle-based assay for detection of specific pathogens. Gold nanoparticles are known to have unique and high surface area. This makes them an ideal candidate for pathogen specific detection. The gold nanoparticles have unique physicochemical properties which are more advantageous over existing conventional detection methods. This review focused on the application of nanotechnology in microbial pathogen detection. With an insight on the exploration of nanotechnology to overcome the limitation of existing detection methods.

show abstract

EMERGENCE OF CARBAPENEM RESISTANCE AMONG EXTENDED SPECTRUM BETA-LACTAMASE ISOLATE OF Escherichia coli FROM CLINICAL SPECIMENS IN A TERTIARY HOSPITAL, NIGERIA

Cited by 8 publications

References 0 publications

Beta-lactamase resistance genes in Enterobacteriaceae from Nigeria

Beta-lactamase resistance genes in Enterobacteriaceae from Nigeria

Probiotics: Current Trend in Combating Antimicrobial Resistance

Nanotechnology: Current trends in detections of microbial pathogens

Contact Info

Product

Resources

About