Emergence of coryneforms in osteomyelitis and orthopaedic surgical site infections

Abstract

The study highlights the fact that the coryneforms are no longer just opportunistic pathogens but they are also becoming important pathogens among immunocompetent individuals as well. The emergence of drug resistance amongst these isolates is of most concern. More studies should be done on identification and on antimicrobial susceptibility of these organisms for the proper treatment of patients with such infections.

Bone and Joint Infection Involving Corynebacterium spp.: From Clinical Features to Pathophysiological Pathways

“…These differences can be explained by our stringent bacteriological definition of cases. Finally, the species distribution slightly differed from previous studies, with a predominance of C. striatum and C. tuberculostearicum, and less C. amycolatum and Corynebacterium jekeium than previously described (36,48).…”

“…Representing more than 3% of PJI etiologic agents (34)(35)(36), Corynebacterium spp. have been largely neglected in this field.…”

“…As part of normal human skin microbiota, corynebacteria can be implicated in inoculation disease. They are especially involved in up to 3% of BJI (34)(35)(36). However, little is known about the specific aspects of Corynebacterium spp.…”

Strain- and Species-Level Variation in the Microbiome of Diabetic Wounds Is Associated with Clinical Outcomes and Therapeutic Efficacy

“…in DFU, detected in 28% of our specimens. It is also considered an emerging multi-drug resistant microbe (Hahn et al, 2016) and may be an underrecognized cause of diabetic foot osteomyelitis (Patel et al, 2016;Rizvi et al, 2011), suggesting it should not be classified as merely contaminating skin flora in the clinic. Our in vivo findings in a diabetic murine model of impaired healing support this hypothesis, where wounds appeared closed at 28 weeks but histopathology revealed a hyperproliferative epidermal layer consistent with delayed healing.…”

Üst Solunum Yolu Enfeksiyonu Bulguları ile Başvuran Çocukların Boğaz Sürüntü Örneklerinde Corynebacterium diphtheriae, Corynebacterium ulcerans ve Corynebacterium pseudotuberculosis Suşlarının Araştırılması

“…Toksin üretimi olmadığında bile C.diphtheriae'nın bakteremi ve menenjit, endokardit, osteomiyelit, septik artrit, hepatit ve periferik embolik hastalık gibi ciddi komplikasyonlara yol açtığı bildirilmiştir 11,[15][16][17][18] . Toksijenik olmayan suşlarla invaziv enfeksiyonlar için immün yetmezlik, diyabet, kronik karaciğer hastalığı, konjenital ya da kalp kapak hastalıkları, intravenöz ilaç alışkanlığı, alkolizm gibi risk faktörleri söz konusudur.…”