Emergence of enterovirus D68 clade D1, France, August to November 2018

Bal, Antonin; Sabatier, Marina; Wirth, Thierry; Coste‐Burel, Marianne; Lazrek, Mouna; Stéfic, Karl; Brengel‐Pesce, Karen; Morfin, Florence; Lina, Bruno; Schuffenecker, Isabelle; Josset, Laurence

doi:10.2807/1560-7917.es.2019.24.3.1800699

Cited by 36 publications

(61 citation statements)

References 16 publications

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“…Interestingly, 66% of sequences from 2017-2018 which belonged to subclade D1 were identified in adult patients with respiratory symptoms, suggesting a possible different epidemiology of this new strain. These findings had already been observed in previous studies [30].…”

Section: Discussionsupporting

confidence: 90%

“…The phylogenetic tree showed that most of the Spanish EV-D68 sequences detected during 2016 clustered to the recently described lineage B3 [33], while strains from 2014 and 2015 belonged to subclade B2. Similar results have been obtained with other studies [34,35], suggesting that all the 2016 outbreaks would be [28][29][30]. These findings indicate that although EV-D68 epidemics can be due to the emergence of new lineages, multiple clades have been circulating simultaneously worldwide from 2010 to the present day.…”

Section: Discussionsupporting

confidence: 89%

“…In 2016 and 2018, however, it circulated almost throughout the year, with a higher incidence in spring and summer. This seasonal distribution, in which EV-D68 has periods of low circulation followed by others with high incidence, has been reported in other countries [29,30,[33][34][35], and suggest epidemics of EV-D68 in 2016 and 2018, which was confirmed by phylogenetic analyses of partial VP1 sequences showing increased genetic diversity. The phylogenetic tree showed that most of the Spanish EV-D68 sequences detected during 2016 clustered to the recently described lineage B3 [33], while strains from 2014 and 2015 belonged to subclade B2.…”

Section: Discussionsupporting

confidence: 81%

“…Spanish sequences from 2014 and 2015 clustered in subclade B2 whereas those detected in 2016 belonged to the subclade B3. However, most of the EV-D68 sequences from 2017 and 2018 (35/51, 68.6%) clustered in the recently described subclade D1 [28][29][30]. Finally, strains collected in our laboratory before 2014 (2010-2011) fell into clade A (Figure 3).…”

Section: Ev-d68 Infection In Non-respiratory Diseasesmentioning

confidence: 76%

“…Finally, all neurological EV-D68 strains belonged to subclades B2/B3 or D1. These emerging genotypes are considered to have more neurotropic potential than A or C strains [30,36,37].…”

Section: Discussionmentioning

confidence: 99%

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Enterovirus D68-associated respiratory and neurological illness in Spain, 2014–2018

González-Sanz

Taravillo

Reina

et al. 2019

Emerging Microbes & Infections

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During 2014, enterovirus D68 (EV-D68) outbreaks were described globally, causing severe respiratory diseases in children and, in some cases, subsequent paralysis. In this study, the type characterization of enterovirus (EV) detected in respiratory illnesses and the epidemiology and clinical association of EV-D68 infections in Spain over a five-year period were described. A total of 546 EV-positive samples from hospitalized patients with respiratory infections were included. EV-D68 was the most frequently detected type (46.6%, 191/410 typed EV). Other EV from species A (25.1%), B (27.8%) and C (0.5%) were also identified. EV-D68 infections were more associated with bronchitis while EV-A/B types were more frequent in upper respiratory illness (p < 0.01). EV-D68 was also detected in patients with neurological symptoms (nine meningitis/meningoencephalitis and eight acute flaccid paralysis cases). Phylogenetic analysis of 3′-VP1 region showed most Spanish EV-D68 sequences from 2014 to 2016 belonged to subclades B2/B3, as other American and European strains circulating during the same period. However, those detected in 2017 and 2018 clustered to the emerged subclade D1. In summary, different EV can cause respiratory infections but EV-D68 was the most prevalent, with several strains circulating in Spain at least since 2014. Association between EV-D68 infection and neurological disease was also described.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 81%

Section: Ev-d68 Infection In Non-respiratory Diseasesmentioning

confidence: 76%

“…Finally, all neurological EV-D68 strains belonged to subclades B2/B3 or D1. These emerging genotypes are considered to have more neurotropic potential than A or C strains [30,36,37].…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Enterovirus D68-associated respiratory and neurological illness in Spain, 2014–2018

González-Sanz

Taravillo

Reina

et al. 2019

Emerging Microbes & Infections

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Enterovirus D68 disease burden and epidemiology in hospital‐admitted influenza‐like illness, Valencia region of Spain, 2014–2020 influenza seasons

Mengual‐Chuliá,

Tamayo‐Trujillo,

Mira‐Iglesias

et al. 2024

Journal of Medical Virology

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Enterovirus D68 (EV‐D68) is an emerging agent for which data on the susceptible adult population is scarce. We performed a 6‐year analysis of respiratory samples from influenza‐like illness (ILI) admitted during 2014‐2020 in 4‐10 hospitals in the Valencia Region, Spain. EV‐D68 was identified in 68 (3.1%) among 2210 Enterovirus (EV)/Rhinovirus (HRV) positive samples. Phylogeny of 59 VP1 sequences showed isolates from 2014 clustering in B2 (6/12), B1 (5/12), and A2/D1 (1/12) subclades; those from 2015 (n = 1) and 2016 (n = 1) in B3 and A2/D1, respectively; and isolates from 2018 in A2/D3 (42/45), and B3 (3/45). B1 and B2 viruses were mainly detected in children (80% and 67%, respectively); B3 were equally distributed between children and adults; whereas A2/D1 and A2/D3 were observed only in adults. B3 viruses showed up to 16 amino acid changes at predicted antigenic sites. In conclusion, two EV‐D68 epidemics linked to ILI hospitalized cases occurred in the Valencia Region in 2014 and 2018, with three fatal outcomes and one ICU admission. A2/D3 strains from 2018 were associated with severe respiratory infection in adults. Because of the significant impact of non‐polio enteroviruses in ILI and the potential neurotropism, year‐round surveillance in respiratory samples should be pursued.

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Epidemics of Hand, Foot, and Mouth Disease

Zhang

2024

Molecular Biology of Hand-Foot-Mouth Diseases

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Emergence of enterovirus D68 clade D1, France, August to November 2018

Cited by 36 publications

References 16 publications

Enterovirus D68-associated respiratory and neurological illness in Spain, 2014–2018

Enterovirus D68-associated respiratory and neurological illness in Spain, 2014–2018

Enterovirus D68 disease burden and epidemiology in hospital‐admitted influenza‐like illness, Valencia region of Spain, 2014–2020 influenza seasons

Epidemics of Hand, Foot, and Mouth Disease

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