Emergence of environmental antibiotic resistance: Mechanism, monitoring and management

Bobate, Shishir; Mahalle, Sejal; Dafale, Nishant A.; Bajaj, Abhay

doi:10.1016/j.envadv.2023.100409

Cited by 20 publications

(4 citation statements)

References 137 publications

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“…Bacteria can alter their outer membrane porins, reducing antibiotic uptake, and, thereby, conferring resistance. Additionally, the enzymatic inactivation of antibiotics through less well-characterized mechanisms or the presence of chromosomal mutations that confer resistance could also play roles [ 12 ]. Furthermore, short-read sequencing tends to produce errors and limitations that may impact the accuracy of results, especially in complex genomic regions or when dealing with highly similar sequences [ 13 ].…”

Section: Resultsmentioning

confidence: 99%

Genomic Characterization of Multidrug-Resistant Enterobacteriaceae Clinical Isolates from Southern Thailand Hospitals: Unraveling Antimicrobial Resistance and Virulence Mechanisms

Yaikhan,

Suwannasin,

Singkhamanan

et al. 2024

Antibiotics

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The emergence and spread of antimicrobial resistance (AMR) among Enterobacteriaceae pose significant threats to global public health. In this study, we conducted a short-term surveillance effort in Southern Thailand hospitals to characterize the genomic diversity, AMR profiles, and virulence factors of Enterobacteriaceae strains. We identified 241 carbapenem-resistant Enterobacteriaceae, of which 12 were selected for whole-genome sequencing (WGS) and genome analysis. The strains included Proteus mirabilis, Serratia nevei, Klebsiella variicola, Klebsiella aerogenes, Klebsiella indica, Klebsiella grimontii, Phytobacter ursingii, Phytobacter palmae, Kosakonia spp., and Citrobacter freundii. The strains exhibited high levels of multidrug resistance, including resistance to carbapenem antibiotics. Whole-genome sequencing revealed a diverse array of antimicrobial resistance genes (ARGs), with strains carrying genes for ß-lactamase, efflux pumps, and resistance to other antibiotic classes. Additionally, stress response, metal tolerance, and virulence-associated genes were identified, highlighting the adaptability and pathogenic potential of these strains. A plasmid analysis identified several plasmid replicons, including IncA/C2, IncFIB(K), and Col440I, as well as several plasmids identical to those found globally, indicating the potential for the horizontal gene transfer of ARGs. Importantly, this study also identified a novel species of Kosakonia spp. PSU27, adding to the understanding of the genetic diversity and resistance mechanisms of Enterobacteriaceae in Southern Thailand. The results reported in this study highlight the critical importance of implementing effective antimicrobial management programs and developing innovative treatment approaches to urgently tackle AMR.

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Section: Resultsmentioning

confidence: 99%

Genomic Characterization of Multidrug-Resistant Enterobacteriaceae Clinical Isolates from Southern Thailand Hospitals: Unraveling Antimicrobial Resistance and Virulence Mechanisms

Yaikhan,

Suwannasin,

Singkhamanan

et al. 2024

Antibiotics

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“…[80] Phage-mediated mechanism has been established as a significant driver for the transmission of ARGs related to tetracycline and β-lactam antibiotics in Staphylococcus aureus, as documented by some studies. [17,81] Further, transduction is also associated with emergence of multi-drug resistance to variety of antibiotics as observed among strains of Streptococcus pyogenes, Enterococci, Escherichia coli, Salmonella, and methicillin-resistant Staphylococcus aureus (MRSA). [82] Transformation.…”

Section: Amr Emergence Transfer and Dissemination In Aquaculturementioning

confidence: 99%

“…The use of antimicrobials, whether warranted or not, has the potential for the development of AMR among microorganisms. It is essential to acknowledge that antimicrobials are frequently employed worldwide for prophylactic purposes and as growth promoters in animal husbandry and agriculture [17]. People and animals regularly exchange strains of antibiotic-resistant bacteria within the ecosystems in which they coexist.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Resistance in Aquaculture: Risk Mitigation within One Health Context

Milijasevic,

Veskovic-Moracanin,

Babic Milijasevic

et al. 2024

Preprint

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The application of antimicrobials in aquaculture primarily aims to prevent and treat bacterial infections in fish. Inappropriate use of antimicrobials in fish farming may result in the emergence of zoonotic antibiotic-resistant bacteria and subsequent transmission of resistant strains to humans via food consumption. From recently, AMR emerged as a significant public health concern in the aquaculture ecosystem and fisheries. The aquatic environment serves as a potential reservoir for resistant bacteria, with aquaculture practices providing an ideal breeding ground for AMR due to the excessive use of antimicrobials to prevent and treat diseases. The mutual inter-connection of intensive fish farming systems with terrestrial environments, food processing industry and human population creates pathways for the transmission of resistant bacteria, exacerbating the problem further. One Health concept, which recognizes the interconnectedness of human, animal and environmental health, enables a holistic approach to address the challenges posed by AMR. By understanding the evolution of such approach, the future of aquaculture, being the important source of a global animal protein supply, can be safeguarded. Risk mitigation strategies for AMR should be based on One Health concept to contribute to sustainable aquaculture practices that protect human and animal health, ensure food safety and protection of environment.

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“…The very wide spread of genetic determinants responsible for antibiotic resistance also makes the presence and entry of environmental bacteria into hospital settings of crucial importance. In fact, exposure to antibiotic molecules or other antimicrobial compounds [11] and sharing ecological niches with microorganisms that have resistance genes can potentially promote the evolution of resistant bacteria [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Pannonibacter anstelovis sp. nov. Isolated from Two Cases of Bloodstream Infections in Paediatric Patients

Castellana,

De Laurentiis,

Bianco

et al. 2024

Microorganisms

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This study describes two cases of bacteraemia sustained by a new putative Pannonibacter species isolated at the U.O.C. of Microbiology and Virology of the Policlinico of Bari (Bari, Italy) from the blood cultures of two patients admitted to the Paediatric Oncohaematology Unit. Pannonibacter spp. is an environmental Gram-negative bacterium not commonly associated with nosocomial infections. Species identification was performed using Sanger sequencing of the 16S rRNA gene and Whole-Genome Sequencing (WGS) for both strains. Genomic analyses for the two isolates, BLAST similarity search, and phylogeny for the 16S rDNA sequences lead to an assignment to the species Pannonibacter phragmitetus. However, by performing ANIb, ANIm, tetranucleotide correlation, and DNA-DNA digital hybridization, analyses of the two draft genomes showed that they were very different from those of the species P. phragmitetus. MALDI-TOF analysis, assessment of antimicrobial susceptibility by E-test method, and Analytical Profile Index (API) tests were also performed. This result highlights how environmental bacterial species can easily adapt to the human host and, especially in nosocomial environments, also gain pathogenic potential through antimicrobial resistance.

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Emergence of environmental antibiotic resistance: Mechanism, monitoring and management

Cited by 20 publications

References 137 publications

Genomic Characterization of Multidrug-Resistant Enterobacteriaceae Clinical Isolates from Southern Thailand Hospitals: Unraveling Antimicrobial Resistance and Virulence Mechanisms

Genomic Characterization of Multidrug-Resistant Enterobacteriaceae Clinical Isolates from Southern Thailand Hospitals: Unraveling Antimicrobial Resistance and Virulence Mechanisms

Antimicrobial Resistance in Aquaculture: Risk Mitigation within One Health Context

Pannonibacter anstelovis sp. nov. Isolated from Two Cases of Bloodstream Infections in Paediatric Patients

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