Emergence of Gastrointestinal Basidiobolomycosis in the United States, With a Review of Worldwide Cases

Vikram, Holenarasipur R.; Smilack, Jerry D.; Leighton, Jonathan A.; Crowell, Michael D.; Petris, Giovanni De

doi:10.1093/cid/cis250

Cited by 123 publications

(254 citation statements)

References 32 publications

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“…Some of our patients also showed fever of~38-38.5 uC. This is the same as earlier reports (Vikram et al, 2012).…”

Section: Discussionsupporting

confidence: 93%

“…Following that report, over the past three decades, several documented cases have been reported worldwide (Vikram et al, 2012). GIB is defined and diagnosed initially on the basis of characteristic histopathological findings in tissue specimens, or isolation of the fungus from specimens (Lyon et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge, fewer than 50 cases of gastrointestinal involvement with B. ranarum have been reported in the English literature to date (Vikram et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Gastrointestinal basidiobolomycosis, an emerging infection in the immunocompetent host: a report of 14 patients

Geramizadeh

Foroughi

Keshtkar-Jahromi

et al. 2012

Journal of Medical Microbiology

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Zygomycosis is characterized by tissue invasion with broad, non-septate hyphae of species such as Rhizopus, Rhizomucor, Lichtheimia (Absidia) and Basidiobolus. Basidiobolus ranarum usually causes subcutaneous infection, and gastrointestinal manifestations in immunocompetent patients have rarely been reported. It is difficult to diagnose gastrointestinal basidiobolomycosis because of the non-specific clinical presentation and the absence of a definite risk factor. This study identified 14 cases of gastrointestinal basidiobolomycosis, all of which were diagnosed after surgery by characteristic histopathological findings. Diagnosis of this disease requires a high index of suspicion in patients presenting with abdominal symptoms, fever, gastrointestinal mass and eosinophilia accompanied by a high erythrocyte sedimentation rate.

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“…Some of our patients also showed fever of~38-38.5 uC. This is the same as earlier reports (Vikram et al, 2012).…”

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Gastrointestinal basidiobolomycosis, an emerging infection in the immunocompetent host: a report of 14 patients

Geramizadeh

Foroughi

Keshtkar-Jahromi

et al. 2012

Journal of Medical Microbiology

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“…It is also an emerging infection in southwestern United States, with 19 cases reported through March 2012. 17 were residents of Arizona [5].…”

Section: Discussionmentioning

confidence: 99%

A Case of Subcutaneous and Gastrointestinal Basidiobolomycosis in Singapore

Ean¹,

Hock²,

Wijaya³

2017

Journal of Microbiology and Infectious Diseases

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Entomophthoromycosis due to Basidiobolus is a known cause of subcutaneous zygomycosis. It occasionally causes invasive disease involving the gastrointestinal tract. We describe a case of proven subcutaneous entomophthoromycosis, with subsequent development of gastrointestinal basidiobolomycosis, in a 67 year old Singaporean Chinese male. He presented with a progressively enlarging left inguinal mass with intra-abdominal extension, causing compression of the ureters and hydronephroses. He underwent multiple biopsies to ascertain the cause of the mass. Workup for malignancy, bacteria, fungal, parasitic and tuberculous infections were negative. He developed worsening gastrointestinal distension a year from initial presentation. Imaging showed mucosal thickening extending from the descending colon to the rectum. Based on the clinical presentation, he was treated as for basidiobolomycosis. He responded poorly to treatment and passed away two months after initiation of therapy. With the help of our counterparts in India, we proved our clinical suspicion by polymerase chain reaction on tissue specimen. J Microbiol Infect Dis 2017; 7(3):151-155

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“…Genome information from pathogens of economically important crop pests will provide insight into pathogenicity mechanisms, and could improve the use of these fungi as bio-control agents. Some Basidiobolus species are known to infect humans [19]. Besides being of practical interest, sequencing these genomes will help to resolve questions around the origin of terrestrial fungi, because Entomophthoromycota is probably one of the earliest terrestrial fungal groups [20].…”

Section: Entomophthoromycotamentioning

confidence: 99%