The impact of tourism on quality of life standards in regions is significant in terms of people, planet, and profit. This paper examines the subnational NUTS 2 level regions, (in line with Eurostat) by applying several interlinked and connected indicators. Adopting the three Ps (people, planet, profit) of the Sustainability Services Marketing Mix, this article discusses the fusion of 54 regions of Central and Eastern Europe (Czech Republic, Slovakia, Hungary, Poland, Estonia, Lithuania, Latvia, Slovenia, Romania, and Bulgaria) into clusters according to the selected accommodation tourism indicators used by the European Statistical Agency (Eurostat) to evaluate tourism. Since many variables of the Prague region significantly exceed the values of the remaining regions, this region has been considered as an individual cluster, excluded from the cluster analysis. The cluster analysis resulted in the definition of six clusters consisting of regions with similar indicators’ statistics characteristics. The presented approach changes the traditional approach to clusters in tourism and provokes thinking about new criteria of clustering and solutions in the field of tourism, especially when considering future cooperation, competitiveness, and sustainable development.