Emergence of H274Y oseltamivir-resistant A(H1N1) influenza viruses in Japan during the 2008–2009 season

Baranovich, Tatiana; Saito, Reiko; Suzuki, Yasushi; Zaraket, Hassan; Dapat, Clyde; Caperig-Dapat, Isolde; Oguma, Taeko; Shabana, Iman; Saito, Takehiko; Sano, Hiroshi

doi:10.1016/j.jcv.2009.11.003

Cited by 94 publications

(76 citation statements)

References 27 publications

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“…In contrast to the sporadic detections of ORV in 2008, we found a high prevalence of oseltamivir-resistant seasonal A (H1N1) viruses (94.4%) during 2009, similar to the observations in other parts of the world since their emergence in Norway in 2007 (11). Oseltamivir is rarely used to treat influenza virus infection in Guangdong, and all ORVs from Guangdong clustered phylogenetically with the Northern European lineage carrying a D354G substitution on the NA protein (2,27) and with ORVs from the United States and Japan which were isolated before the emergence of ORVs in Guangdong.…”

Section: Discussionsupporting

confidence: 71%

Adamantane- and Oseltamivir-Resistant Seasonal A (H1N1) and Pandemic A (H1N1) 2009 Influenza Viruses in Guangdong, China, during 2008 and 2009

et al. 2011

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Section: Discussionsupporting

confidence: 71%

Adamantane- and Oseltamivir-Resistant Seasonal A (H1N1) and Pandemic A (H1N1) 2009 Influenza Viruses in Guangdong, China, during 2008 and 2009

et al. 2011

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“…This is not unexpected, given the generally low antiviral uptake in Italy and Europe. During the 2008-2009 seasonal influenza, there was a dramatic increase in the oseltamivir-resistant strain circulation in some countries [14]. In addition, phylogenetic analysis did not show any clear clustering, although a differentiation from the original Puerto Rico Strain occurred.…”

Section: Sequence and Phylogenetic Analysismentioning

confidence: 93%

Clinical presentation, microbiological features and correlates of disease severity of 2009 pandemic influenza A (H1N1) infection

Giambenedetto¹,

Verme²,

Sali³

et al. 2010

Eur J Clin Microbiol Infect Dis

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International audienceThe purpose of this study was to describe epidemiological, clinical and microbiological characteristics of confirmed novel influenza A (H1N1) infection, investigating factors associated with disease severity. We retrospectively selected patients seeking care for respiratory symptoms in two periods (May-August and September-November 2009) with different epidemiological characteristics. Only patients with confirmed pandemic influenza A (H1N1) were enrolled in this study. A total of 104 patients with H1N1 infection were evaluated, mostly referring classic influenza symptoms; in addition, diarrhea and vomiting were often referred. Clinical signs, symptoms and respiratory complications were different in the two periods. Of all patients, 18 (17%) had pneumonia. Patients older than 50 years showed a lower probability of pneumonia diagnosis when compared to children aged 0-13 ( = 0.049); a longer duration of symptoms before medical care was associated with a higher probability of pneumonia ( = 0.026). Phylogenetic analysis showed a low variability both in hemagglutinin and neuraminidase genes. In addition, no neuraminidase mutation associated with antiviral resistance was detected. A detailed description of respiratory diseases associated with H1N1 infection was provided and factors associated with its severity were investigated, thus contributing to the insight into epidemiological, clinical and microbiological knowledge of the disease

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“…By the 2008–2009 season, many countries were reporting up to 100% oseltamivir resistance among seasonal influenza A(H1N1) viruses 14, 15. In contrast, oseltamivir resistance among the pandemic A(H1N1)pdm09 viruses circulating in 2009–2010 was <1% in the United States, with majority of oseltamivir‐resistant viruses recovered from patients with a history of oseltamivir exposure, many of whom were severely immunocompromised 16.…”

Section: Introductionmentioning

confidence: 99%

Neuraminidase inhibitor susceptibility surveillance of influenza viruses circulating worldwide during the 2011 Southern Hemisphere season

Okomo-Adhiambo

Sleeman

Lysen

et al. 2013

Influenza Resp Viruses

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BackgroundNeuraminidase (NA) inhibitors (NAIs) are currently the only antivirals effective against influenza infections due to widespread resistance to M2 inhibitors.MethodsInfluenza A and B viruses (n = 1079) collected worldwide between April 01, 2011, and September 30, 2011, were assessed for susceptibility to FDA‐approved NAIs, oseltamivir and zanamivir, and investigational peramivir, using the fluorescent‐based NA‐Fluor™ Influenza Neuraminidase Assay Kit. A subset of viruses (n = 98) were tested for susceptibility to the investigational NAI, laninamivir.ResultsInfluenza A(H1N1)pdm09 viruses (n = 326) were sensitive to all NAIs, except for two (0·6%) with H275Y (N1 numbering; H274Y in N2 numbering) substitution, which exhibited elevated IC 50s for oseltamivir and peramivir, and a third with previously unreported N325K substitution, exhibiting reduced susceptibility to oseltamivir. Influenza A(H3N2) viruses (n = 407) were sensitive to all NAIs. Influenza B viruses (n = 346) were sensitive to all NAIs, except two (0·6%) with H273Y (N1 numbering; H274Y in N2 numbering) substitution, exhibiting reduced susceptibility to oseltamivir and peramivir, and one with previously unreported G140R and N144K substitutions, exhibiting reduced susceptibility to oseltamivir, zanamivir, and peramivir. All influenza A and B viruses were sensitive to laninamivir. It is unknown whether substitutions N325K, G140R, and N144K were present in the virus prior to culturing because clinical specimens were unavailable for testing.ConclusionsThis study summarizes NAI susceptibility of influenza viruses circulating worldwide during the 2011 Southern Hemisphere (SH) season, assessed using the NA‐Fluor™ Kit. Despite low resistance to NAIs among tested influenza viruses, constant surveillance of influenza virus susceptibility to NAIs should be emphasized.

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Emergence of H274Y oseltamivir-resistant A(H1N1) influenza viruses in Japan during the 2008–2009 season

Cited by 94 publications

References 27 publications

Adamantane- and Oseltamivir-Resistant Seasonal A (H1N1) and Pandemic A (H1N1) 2009 Influenza Viruses in Guangdong, China, during 2008 and 2009

Adamantane- and Oseltamivir-Resistant Seasonal A (H1N1) and Pandemic A (H1N1) 2009 Influenza Viruses in Guangdong, China, during 2008 and 2009

Clinical presentation, microbiological features and correlates of disease severity of 2009 pandemic influenza A (H1N1) infection

Neuraminidase inhibitor susceptibility surveillance of influenza viruses circulating worldwide during the 2011 Southern Hemisphere season

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