Emergence of heart and branchiomeric muscles in cardiopharyngeal mesoderm

Lescroart, Fabienne; Dumas, Camille E.; Adachi, Noritaka; Kelly, Robert G.

doi:10.1016/j.yexcr.2021.112931

Cited by 24 publications

(17 citation statements)

References 102 publications

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“…Striated muscles in the esophagus and larynx share origins in the cranial mesoderm derived from the posterior pharyngeal arches that differentiate into branchiomeric muscle beginning at E13.5. Our data support findings that DEGs enriched for cardiogenesis processes converge on common regulatory programs found in the larynx, trachea, and esophagus (Sambasivan, Kuratani, and Tajbakhsh, 2011;Lescroart et al, 2022). Cardiocraniofacial syndromes such as DiGeorge, Velocardiofacial, CHARGE, Fetal Alcohol, Noonan syndromes, and Retinoic Acid Embryopathy are characterized by a range of comorbidities, including disruptions in the fetal development of shared organs in the aerodigestive tract with cardiac anomalies.…”

Section: Discussionsupporting

confidence: 86%

Transcriptome Dynamics in the Developing Larynx, Trachea, and Esophagus

Wendt

Brown

Lungová

et al. 2022

Front. Cell Dev. Biol.

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The larynx, trachea, and esophagus share origin and proximity during embryonic development. Clinical and experimental evidence support the existence of neurophysiological, structural, and functional interdependencies before birth. This investigation provides the first comprehensive transcriptional profile of all three organs during embryonic organogenesis, where differential gene expression gradually assembles the identity and complexity of these proximal organs from a shared origin in the anterior foregut. By applying bulk RNA sequencing and gene network analysis of differentially expressed genes (DEGs) within and across developing embryonic mouse larynx, esophagus, and trachea, we identified co-expressed modules of genes enriched for key biological processes. Organ-specific temporal patterns of gene activity corresponding to gene modules within and across shared tissues during embryonic development (E10.5-E18.5) are described, and the laryngeal transcriptome during vocal fold development and maturation from birth to adulthood is characterized in the context of laryngeal organogenesis. The findings of this study provide new insights into interrelated gene sets governing the organogenesis of this tripartite organ system within the aerodigestive tract. They are relevant to multiple families of disorders defined by cardiocraniofacial syndromes.

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Section: Discussionsupporting

confidence: 86%

Transcriptome Dynamics in the Developing Larynx, Trachea, and Esophagus

Wendt

Brown

Lungová

et al. 2022

Front. Cell Dev. Biol.

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“…Although head muscles resemble limb and trunk muscles in myofiber architecture, their developmental history is widely divergent [ 11 ]. Branchiomeric muscles and their accompanying muscle stem cells develop from the cranial mesoderm (also known as pharyngeal mesoderm), which includes both the cranial paraxial mesoderm and lateral splanchnic mesoderm [ 1 , 25 , 26 , 27 , 28 ]. The pharyngeal mesoderm forms the mesodermal core within the pharyngeal arches (also known as branchial arches), which are transitory structures in the vertebrate embryo that bulge ventrally in pairs from the pharynx [ 1 , 5 ].…”

Section: An Overview Of Early Branchiomeric Muscle Developmentmentioning

confidence: 99%

“…The pharyngeal mesoderm forms the mesodermal core within the pharyngeal arches (also known as branchial arches), which are transitory structures in the vertebrate embryo that bulge ventrally in pairs from the pharynx [ 1 , 5 ]. Each arch comprises a mesodermal core surrounded by neural crest cells, endoderm, and ectoderm, which tightly influence mesodermal cell development [ 26 , 29 ]. The mesodermal core of the pharyngeal arches gives rise to the branchiomeric muscles and significant parts of the heart [ 1 , 6 , 26 , 29 , 30 , 31 , 32 , 33 , 34 ].…”

Section: An Overview Of Early Branchiomeric Muscle Developmentmentioning

confidence: 99%

“…Each arch comprises a mesodermal core surrounded by neural crest cells, endoderm, and ectoderm, which tightly influence mesodermal cell development [ 26 , 29 ]. The mesodermal core of the pharyngeal arches gives rise to the branchiomeric muscles and significant parts of the heart [ 1 , 6 , 26 , 29 , 30 , 31 , 32 , 33 , 34 ]. The first and second pharyngeal arches give rise to masticatory and facial expression muscles, and posterior pharyngeal arches give rise to non-somitic neck muscles and esophagus striated muscles, respectively ( Figure 1 ) [ 1 , 6 , 25 , 26 , 28 , 31 , 35 ].…”

Section: An Overview Of Early Branchiomeric Muscle Developmentmentioning

confidence: 99%

“…The mesodermal core of the pharyngeal arches gives rise to the branchiomeric muscles and significant parts of the heart [ 1 , 6 , 26 , 29 , 30 , 31 , 32 , 33 , 34 ]. The first and second pharyngeal arches give rise to masticatory and facial expression muscles, and posterior pharyngeal arches give rise to non-somitic neck muscles and esophagus striated muscles, respectively ( Figure 1 ) [ 1 , 6 , 25 , 26 , 28 , 31 , 35 ]. Moreover, a recent mouse genetic lineage analysis revealed that pharyngeal mesoderm contributes to the medial pharyngeal skeleton and branchiomeric muscle elements (connective tissue) [ 36 ].…”

Section: An Overview Of Early Branchiomeric Muscle Developmentmentioning

confidence: 99%

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New Insights into the Diversity of Branchiomeric Muscle Development: Genetic Programs and Differentiation

Yahya

Hockman

Brand‐Saberi

et al. 2022

Biology

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Branchiomeric skeletal muscles are a subset of head muscles originating from skeletal muscle progenitor cells in the mesodermal core of pharyngeal arches. These muscles are involved in facial expression, mastication, and function of the larynx and pharynx. Branchiomeric muscles have been the focus of many studies over the years due to their distinct developmental programs and common origin with the heart muscle. A prerequisite for investigating these muscles’ properties and therapeutic potential is understanding their genetic program and differentiation. In contrast to our understanding of how branchiomeric muscles are formed, less is known about their differentiation. This review focuses on the differentiation of branchiomeric muscles in mouse embryos. Furthermore, the relationship between branchiomeric muscle progenitor and neural crest cells in the pharyngeal arches of chicken embryos is also discussed. Additionally, we summarize recent studies into the genetic networks that distinguish between first arch-derived muscles and other pharyngeal arch muscles.

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Organization of the body wall in lampreys informs the evolution of the vertebrate paired appendages

Onai

2023

Journal of Morphology

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Vertebrate paired appendages are one of the most important evolutionary novelties in vertebrates. During embryogenesis, the skeletal elements of paired appendages differentiate from the somatic mesoderm, which is a layer of lateral plate mesoderm. However, the presence of the somatic mesoderm in the common ancestor of vertebrates has been controversial. To address this problem, it is necessary but insufficient to understand the developmental process of lateral plate mesoderm formation in lamprey (jawless vertebrates) embryos. Here, I show the presence of the somatic mesoderm in lamprey (Lethenteron camtschaticum) embryos using plastic sectioning and transmission electron microscopy analysis. During the early pharyngeal stages, the somatic mesoderm transforms from the lateral plate mesoderm in the trunk region. Soon after, when the cardiac structures were morphologically distinct, the somatic mesoderm was recognized through the cardiac to more caudal regions. These findings indicated that the somatic mesoderm evolved before the emergence of paired appendages. I also discuss the developmental changes in the body wall organization in the common ancestor of vertebrates, which is likely related to the evolution of the paired appendages.

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Emergence of heart and branchiomeric muscles in cardiopharyngeal mesoderm

Cited by 24 publications

References 102 publications

Transcriptome Dynamics in the Developing Larynx, Trachea, and Esophagus

Transcriptome Dynamics in the Developing Larynx, Trachea, and Esophagus

New Insights into the Diversity of Branchiomeric Muscle Development: Genetic Programs and Differentiation

Organization of the body wall in lampreys informs the evolution of the vertebrate paired appendages

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