Emergence of High-Level Azithromycin Resistance in Campylobacter jejuni Isolates from Pediatric Diarrhea Patients in Kolkata, India

Mukherjee, Piyali; Ramamurthy, T.; Mitra, U; Mukhopadhyay, Asish K.

doi:10.1128/aac.02931-14

Cited by 31 publications

(24 citation statements)

References 9 publications

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“…However, in certain cases, antibiotics such as macrolides or flouroquinolones might be needed. Unfortunately, worldwide reports of drugresistant Campylobacter in humans, poultry, and food have been published which threatens our goal of treating millions of people around the world [21][22][23][24][25][26]. The CDC considers Campylobacter drug resistance as a serious threat [27].…”

Section: Introductionmentioning

confidence: 99%

Bibliometric analysis of publications on Campylobacter: (2000–2015)

Sweileh

Al-Jabi

Sawalha

et al. 2016

J Health Popul Nutr

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Background Campylobacter species are widespread zoonotic pathogens. Campylobacter jejuni causes a form of gastroenteritis called campylobacteriosis. Campylobacter drug resistance is considered a serious threat. In order to better understand national and international research output on Campylobacter, we conducted this bibliometric overview of publications on Campylobacter. This study can be used to assess extent of interaction and response of researchers, food regulators, and health policy makers to global burden of campylobacateriosis.MethodsScopus database was used to retrieve publications with the following keywords (Campylobacter/campylobacteriosis, C. jejuni, C. coli). The study period was set from 2000 to 2015. All types of journal documents, excluding errata, were considered. Bibliometric indicators such as annual growth of publications, country contribution, international collaboration, and citation analysis were presented. The quality of retrieved data was indirectly assessed by Hirsch index and impact factor of journals.ResultsA total of 5522 documents were retrieved with median (Q1–Q3) citations of 9 (2–23) and h-index of 113. Annual number of publications showed a fluctuating increase. The core leading journals were Applied and Environmental Microbiology journal and Journal of Food Protection with 246 (4.46%) publications for each. The USA (1309; 23.6%) was the most productive country while Danmarks Tekniske Universitet (150; 2.7%) was the most productive institution. Half of the top ten productive countries were European. France had the lowest percentage (33.5%) of articles with international collaboration while Netherlands (57.7%) had the highest percentage of articles with international collaboration. Approximately half (50.1%) of retrieved articles were published in journals under the subject area of “immunology/microbiology”. Main themes in highly cited articles were molecular biology/genetics and public health burden of campylobacteriosis. There were 728 (13.1%) articles on campylobacter-related drug resistance, and the top cited articles focused mainly on increasing resistance to quinolones and fluoroquinolones.ConclusionsThere was a clear increase in number of publications on Campylobacter. Rational use of antimicrobials in humans, poultry, and animals is highly recommended. International collaboration is highly required particularly in implementing new diagnostic screening technologies to minimize global health burden of Campylobacter and ensure food safety.

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Section: Introductionmentioning

confidence: 99%

Bibliometric analysis of publications on Campylobacter: (2000–2015)

Sweileh

Al-Jabi

Sawalha

et al. 2016

J Health Popul Nutr

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“…Resistance against fluoroquinolones has increased substantially over the last decade [61,62] and macrolide resistance has been increasingly described [63-65]. Although treatment of Campylobacter enteritis for the general population beyond the immunosuppressed or pregnant remains somewhat controversial, severe disease is not uncommon in undernourished children in the developing world, and the diminishing number of susceptible oral therapies is concerning.…”

Section: Introductionmentioning

confidence: 99%

Update on the burden of Campylobacter in developing countries

Platts-Mills

Kosek

2014

Current Opinion in Infectious Diseases

126

103

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Purpose of review Recent work has added to the understanding of the burden of Campylobacter jejuni, C. coli, and non-jejuni/coli Campylobacter strains in children living in the developing world. Recent findings New diagnostic modalities and carefully-designed field studies are demonstrating that the burden of Campylobacter diarrhea in children in the developing world has been greatly underestimated. Furthermore, there is emerging recognition of an association between Campylobacter infection and malnutrition. Important progress has been made towards a Campylobacter jejuni vaccine. Finally, evidence of antibiotic resistance continues to be an important issue that is accentuated by the realization that the burden of disease is greater than previously recognized. Summary Additional research is needed to refine our understanding of the epidemiology of Campylobacter infections in developing countries, in particular to improve estimates of the burden of Campylobacter diarrhea in endemic settings, to determine the impact of recurrent Campylobacter infections on child development, and to describe the prevalence and clinical significance of non-jejuni/coli Campylobacter infections. Progressive antibiotic resistance of isolates argues for augmented and expanded control measures of antibiotics in livestock. Continued work in vaccine development is warranted as is the extension of data available on the serotypes related to burden in different areas of the world and the relationship of serotypes to disease severity.

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“…Increasing occurrence of MDR pathogens, including Campylobacter spp., has been an alarming global issue for 'One Health', which consider the health of humans, animals, and the environment in a holistic manner [14,16,17]. Campylobacter strains showing resistance to multiple drugs, particularly, nalidixic acid, tetracycline, fluoroquinolones, and macrolides, have been isolated at increasing frequency among patients with gastroenteritis and diarrhea during the last decades in both the developed and developing countries [5,17,18]. In Bangladesh, a developing country, there have been an increasing Government efforts through registered veterinarians to promote a prudent use of antimicrobial agents and only for therapeutic purposes [19], yet these drugs are often applied indiscriminately in the poultry farms.…”

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confidence: 99%

Risk of multi-drug resistant Campylobacter spp. and residual antimicrobials at poultry farms and live bird markets in Bangladesh

Neogi

Islam

et al. 2020

BMC Infect Dis

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Background: Understanding potential risks of multi-drug resistant (MDR) pathogens from the booming poultry sector is a crucial public health concern. Campylobacter spp. are among the most important zoonotic pathogens associated with MDR infections in poultry and human. This study systematically examined potential risks and associated socio-environmental factors of MDR Campylobacter spp. in poultry farms and live bird markets (LBMs) of Bangladesh. Methods: Microbial culture and PCR-based methods were applied to examine the occurrence and MDR patterns of Campylobacter spp. in potential sources (n = 224) at 7 hatcheries, 9 broiler farms and 4 LBMs in three sub-districts. Antimicrobial residues in broiler meat and liver samples (n = 50) were detected by advanced chromatographic techniques. A questionnaire based cross-sectional survey was conducted on socio-environmental factors. Results: Overall, 32% (71/ 224) samples were found contaminated with Campylobacter spp. In poultry farms, Campylobacter spp. was primarily found in cloacal swab (21/49, 43%), followed by drinking water (8/24, 33%), and meat (8/28, 29%) samples of broilers. Remarkably, at LBMs, Campylobacter spp. was detected in higher prevalence (p < 0.05) in broiler meat (14/26, 54%), which could be related (p < 0.01) to bacterial contamination of drinking water (11/21, 52%) and floor (9/21, 43%). Campylobacter isolates, one from each of 71 positive samples, were differentiated into Campylobacter jejuni (66%) and Campylobacter coli (34%). Alarmingly, 49 and 42% strains of C. jejuni and C. coli, respectively, were observed as MDR, i.e., resistant to three or more antimicrobials, including, tetracycline, amoxicillin, streptomycin, fluoroquinolones, and macrolides. Residual antimicrobials (oxytetracycline, ciprofloxacin and enrofloxacin) were detected in majority of broiler liver (79%) and meat (62%) samples, among which 33 and 19%, respectively, had concentration above acceptable limit. Inadequate personal and environmental hygiene, unscrupulously use of antimicrobials, improper waste disposal, and lack of health surveillance were distinguishable risk factors, with local diversity and compound influences on MDR pathogens.Conclusion: Potential contamination sources and anthropogenic factors associated with the alarming occurrence of MDR Campylobacter, noted in this study, would aid in developing interventions to minimize the increasing risks of poultry-associated MDR pathogens under 'One Health' banner that includes poultry, human and environment perspectives.

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Emergence of High-Level Azithromycin Resistance in Campylobacter jejuni Isolates from Pediatric Diarrhea Patients in Kolkata, India

Cited by 31 publications

References 9 publications

Bibliometric analysis of publications on Campylobacter: (2000–2015)

Bibliometric analysis of publications on Campylobacter: (2000–2015)

Update on the burden of Campylobacter in developing countries

Risk of multi-drug resistant Campylobacter spp. and residual antimicrobials at poultry farms and live bird markets in Bangladesh

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