Emergence of Invasive Fungal Rhinosinusitis in Recently Recovered COVID-19 Patients

Dokania, Vivek; Gaikwad, Ninad; Gite, Vinod; Mhashal, Shashikant; Shetty, Neeraj; Shinde, P. N.; Balakrishnan, Anju

doi:10.1177/00034894211060923

Cited by 7 publications

(5 citation statements)

References 28 publications

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“…[ 37 ] India Prospective Single-center 80 May 2021–Aug 2021 – 69 (55) 90 (72) Ismaiel WF. [ 38 ] Egypt Retrospective Single-center 10 – – – – Avatef Fazeli M. [ 39 ] Iran Retrospective Single-center 9 Oct 2020–Nov 2020 59 33 (3) 78 (7) Goddanti N. [ 40 ] India Retrospective Single-center 300 Apr 2021–Jun 2021 49 ± 12 74 (222) 96 (287) Kulkarni R. [ 41 ] India Retrospective Multi-center 49 Dec 2020–Jun 2021 53 ± 11 71 (35) 82 (40) Dokania V. [ 42 ] India Prospective Single-center 21 Apr 2021–Jun 2021 50 ± 14 71 (15) 90 (19) Nair AG. [ 43 ] India Retrospective Multi-ce...…”

Section: Resultsmentioning

confidence: 99%

“…[ 37 ] 75 (60) 1.3 (1) – – – – – – Ismaiel WF. [ 38 ] – – – – – – – – Avatef Fazeli M. [ 39 ] 44 (4) 22 (2) 11 (1) – – 13 (1) 100 (7) 25 (2) Goddanti N. [ 40 ] – – – – 60 (180) – 79 (237) – Kulkarni R. [ 41 ] 37 (18) – – – – – – – Dokania V. [ 42 ] 0.5 (1) – – – – 4.8 (1) 90 (19) 19 (4) Nair AG. [ 43 ] – – – – 38 (5) – 54 (7) …”

Section: Resultsmentioning

confidence: 99%

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Clinical Features and Mortality of COVID-19-Associated Mucormycosis: A Systematic Review and Meta-Analysis

Watanabe

Mitaka

et al. 2022

Mycopathologia

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The recent increase of COVID-19-associated mucormycosis (CAM) has been commanding global attention. However, basic epidemiologic characteristics have not firmly been established. In this systematic review and meta-analysis, we sought to determine the clinical manifestations, potential risk factors, and outcomes of CAM. Observational studies reporting CAM were searched with PubMed and EMBASE databases in January 2022. We collected data on comorbidities and treatment for COVID-19, and performed a one-group meta-analysis on the frequency of orbital exenteration procedure and mortality of CAM using a random-effect model. Fifty-one observational studies, including a total of 2,312 patients with proven CAM, were identified. Among the 51 studies, 37 were conducted in India, 8 in Egypt, and 6 in other countries. The most common comorbidity was diabetes mellitus (82%). While 57% required oxygenation, 77% received systemic corticosteroids. Among CAM, 97% were rhino-orbital-cerebral (ROCM), and 2.7% were pulmonary mucormycosis. Usual presentations were headache (54%), periorbital swelling/pain (53%), facial swelling/pain (43%), ophthalmoplegia (42%), proptosis (41%), and nasal discharge/congestion (36%). Regarding the outcomes, orbital exenteration was performed in 17% (95% CI: 12–21%, I 2 = 83%) of the COVID-19-associated ROCM patients. The mortality of CAM was 29% (95% CI; 22–36%, I 2 = 92%). In conclusion, this systematic review and meta-analysis indicated that the most prevalent type of CAM was ROCM, and most CAM patients had diabetes mellitus and received systemic glucocorticoids. Clinicians in the endemic areas should have a high index of suspicion for this invasive fungal complication of COVID-19 when a diabetic patient who received high-dose systemic glucocorticoids developed rhino-orbital symptoms.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Clinical Features and Mortality of COVID-19-Associated Mucormycosis: A Systematic Review and Meta-Analysis

Watanabe

Mitaka

et al. 2022

Mycopathologia

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“…Human immunodeficiency virus infection and acquired immunodeficiency syndrome, iatrogenic immunodeficiency states in massive antibiotic therapy in chronic infection treatment, long-term use of hormones and immunosuppressive drugs in cases of malignant tumors or autoimmune diseases, bone marrow and organ transplantation increase the risk of bacterial-fungal chronic rhinosinusitis development [10,11,13].…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of fungal rhinosinusitis is markedly more prominent in post-COVID19 patients than in non-COVID-19 [9]. Also, fungal rhinosinusitis was found in patients during COVID-19 infection (COVID-19 associated fungal rhinosinusitis) [10,11]. The most common fungal infections of the nose and paranasal sinuses in patients in…”

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confidence: 99%

Rhinosinusitis in Patients in Post-Covid-19 Period: Etiology, Clinical and Morphological Characteristics

Myroshnychenko

Kalashnyk-Vakulenko

Kapustnyk³

et al. 2022

Wiad Lek

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The aim is to identify the etiology, clinical and morphological features of rhinosinusitis in patients in post-COVID-19 period. Materials and methods: In the present study, it was carried out the analysis of 11 cases of rhinosinusitis, which developed after COVID-19 infection. The diagnosis of rhi¬nosinusitis was established on the basis of anamnesis, clinical and laboratory examination, specialized instrumental examination (rhinoendoscopy, X-ray, magnetic resonance imaging, spiral and 3D computed tomography). All patients underwent endoscopic sanitation of the nasal cavity, expansion of the maxillary anastomosis, maxillary sinusotomy, sanitation of the maxillary sinuses and removal of pathologically altered tissues. Microbiological examination of the swab from the nasal cavity was carried out in all patients. Histological and morphometric research methods were used during the morphological study of surgical material. The nonparametric Mann-Whitney U test was used to compare the means in the groups. Results: The conducted comprehensive study made it possible to identify chronic atrophic rhinosinusitis at the stage of exacerbation caused by associations of bacteria and fungi in patients in post-COVID-19 period. Among bacteria, the authors most often noted Staphylococcus aureus, Staphylococcus epidermidis, Klebsiella pneumonia, Streptococcus pneumonia and Enterococcus faecalis. Among fungi, there were Aspergillus, Candida, Mucor and Coccidioides. Fungal infection was characterized by invasion into the mucous membrane of the nose and paranasal sinuses. In patients in post-COVID-19 period the invasive bacterial-fungal chronic atrophic rhinosinusitis at the stage of exacerbation was predominantly bilateral, characterized by the involvement of several or all paranasal sinuses in the process. Patients with such pathology complained of periodic fever, headaches and malaise; nasal congestion and constant difficulty in nasal breathing; yellowish-greenish-reddish discharge from the nasal cavity, sometimes with a fetid odor; discomfort and pain in the area of paranasal sinuses; immobility of the eyeball, hyposmia or anosmia; reduction or complete loss of vision. Frequent risk factors for the development of invasive bacterial-fungal chronic atrophic rhinosinusitis at the stage of exacerbation in patients in post-COVID-19 period were the information about moderate or severe course of this infection in anamnesis; comorbidities (predominantly diabetes mellitus, hypertensive disease and ischemic heart disease). Conclusions: The study conducted by the authors made it possible to identify the etiological, clinical and morphological features, as well as risk factors of rhinosinusitis in patients in post-COVID-19 period. This information will contribute to a better understanding of such pathology by the doctors and improve the diagnostic and treatment process.

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“…Цель этого обзора -информировать читателей о последних важных достижениях в области ХРС у взрослых. Для этого мы провели поиск литературы по исследованиям, посвященным вышеуказанным темам, с акцентом на публикации в рецензируемых журналах за последние 3 года.ОСНОВНАЯ ЧАСТЬЕвропейский позиционный документ по риносинуситу и назальным полипам -это последняя версия европейского позиционного документа, посвященного всестороннему обзору последних исследований риносинусита[2][3][4][5]. В это издание было внесено несколько обновлений.…”

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Features of the Course of Chronic Rhinosinusitis Against the Background of Covid-19

Ortikov¹,

Khaidarov²,

Bolieva³

2023

ojmp

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Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the upper respiratory tract with a wide range of clinical variants. As our understanding of the pathophysiology of the disease develops, so does our philosophy regarding the approach and treatment of CRS. Endotyping gains an advantage over phenotype-based classifications due to its potential to predict disease severity and provide accurate treatment. Endotyping is particularly useful in complex cases of CRS with a nasal polyp, for which new treatment options such as biologics are now available. The latest European position paper on rhinosinusitis and nasal polyps (EPOS2020) reflects these developments with updated rhinosinusitis classifications and new integrated care schemes.

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Emergence of Invasive Fungal Rhinosinusitis in Recently Recovered COVID-19 Patients

Cited by 7 publications

References 28 publications

Clinical Features and Mortality of COVID-19-Associated Mucormycosis: A Systematic Review and Meta-Analysis

Clinical Features and Mortality of COVID-19-Associated Mucormycosis: A Systematic Review and Meta-Analysis

Rhinosinusitis in Patients in Post-Covid-19 Period: Etiology, Clinical and Morphological Characteristics

Features of the Course of Chronic Rhinosinusitis Against the Background of Covid-19

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