Emergence of Invasive Serotype VIII Group B Streptococcal Infections in Denmark

Ekelund, Kim; Slotved, Hans Christian; Nielsen, Hans Ulrik; Kaltoft, Margit S.; Konradsen, Helle Bossen

doi:10.1128/jcm.41.9.4442-4444.2003

Cited by 20 publications

(12 citation statements)

References 18 publications

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“…In these Danish studies, serotypes Ia, Ib, II, III, and V were predominant, as also observed in the global study by Madrid et al (9). In 2001 and 2002, data from Denmark showed the presence of invasive serotype VIII isolates, which until then were observed virtually only in Japan (12). Since then, all 10 GBS serotypes have been identified in invasive infections in Denmark, although with greatly varying prevalence (13).…”

Section: Introductionsupporting

confidence: 64%

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The Epidemiology of Invasive Group B Streptococcus in Denmark From 2005 to 2018

Slotved

Hoffmann

2020

Front. Public Health

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Previous epidemiology reports on invasive Streptococcus agalactiae (GBS) infections in Denmark did not include all patient age groups. The aim of this study was therefore to analyze the GBS incidence in all age groups during the period 2005-2018 and to present the serotype distribution and the antibiotic susceptibility. Data were retrieved from the Danish laboratory surveillance system, and these included data on typing and susceptibility testing for erythromycin and clindamycin. Early-onset disease (EOD) (mean incidence 0.17 per 1,000 live births) and late-onset disease (LOD) (mean incidence 0.14 per 1,000 live births) showed a low level during the period. The incidence was stable in the age groups 91 days to 4 years, 5-19 years, and 20-64 years. From 2005 to 2018, the incidence in the elderly showed a significantly increasing trend (P < 0.05), that in the 65-74 years increased from 3.23 to 8.34 per 100,000, and that in the 75+ years increased from 6.85 to 16.01 per 100,000. Erythromycin and clindamycin resistance fluctuated over the period; however, the overall trend was increasing. Data showed that EOD and LOD incidence continued to be low, whereas an increasing trend in GBS infections in the elderly was observed. The prevalence of erythromycin and clindamycin resistance increased from 2005 to 2018.

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Section: Introductionsupporting

confidence: 64%

“…None of the previous studies on the epidemiology of invasive GBS infections in Denmark (6,(10)(11)(12) provided detailed information on all age groups. In these Danish studies, serotypes Ia, Ib, II, III, and V were predominant, as also observed in the global study by Madrid et al (9).…”

Section: Introductionmentioning

confidence: 99%

The Epidemiology of Invasive Group B Streptococcus in Denmark From 2005 to 2018

Slotved

Hoffmann

2020

Front. Public Health

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“…However, the serotype distribution has shifted somewhat during the past few years [33]. Pregnant Japanese women were found to be predominantly colonized with serotypes VI and VIII [34], whereas invasive disease was being increasingly caused by serotype VIII in a Danish study [35]. Whether this difference is due to geographic predominance or due to the type of infection remains to be determined.…”

Section: Serotype Distributionmentioning

confidence: 97%

Invasive Group B Streptococcal Disease in Non-pregnant Adults

2008

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Streptococcus agalactiae, commonly referred as group B Streptococcus (GBS), is a major cause of neonatal sepsis and infections in pregnant women. However, the number of invasive infections in non-pregnant adults is growing. Elderly patients and those with chronic underlying conditions, such as diabetes mellitus or compromised immune defence, are at increased risk of invasion. The spectrum of clinical manifestations is broad and includes necrotizing fasciitis and toxic shock syndrome. Although, primary bacteremia and skin and soft-tissue infections are the most frequently reported diagnosis. This article reviews the epidemiology, pathogenesis and treatment of invasive GBS disease in non-pregnant adults, with an emphasis on skin and soft-tissue infections.

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“…Thereafter, incidences of its presence began to be described outside Japan. In Denmark, seven instances of invasive disease isolates belonging to CPS VIII among nonpregnant adults were reported from 1999 to 2002 (51). Also, one isolate colonizing a pregnant woman in Maryland was recognized as CPS VIII (52).…”

Section: Serotypingmentioning

confidence: 99%

Perinatal Streptococcus agalactiae Epidemiology and Surveillance Targets

2018

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SUMMARY, or group B streptococcus (GBS), is a major neonatal pathogen. Recent data have elucidated the global prevalence of maternal and neonatal colonization, but gaps still remain in the epidemiology of this species. A number of phenotypic and genotypic classifications can be used to identify the diversity of GBS strains, and some are more discriminatory than others. This review explores the main schemes used for GBS epidemiology and further details the targets for epidemiological surveillance. Current screening practices across the world provide a unique opportunity to gain detailed information on maternal colonizing strains and neonatal disease-causing strains, which is vital for monitoring and therapeutics, if sufficient detail can be extracted. Deciphering which isolates are circulating within specific populations and recording targets within invasive strains are crucial steps in monitoring the implementation of therapeutics, such as vaccines, as well as developing novel therapies against prevalent GBS strains. Having a detailed understanding of global GBS epidemiology will prove invaluable for understanding the pathogenesis of this organism and equipping future prevention strategies for success.

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Emergence of Invasive Serotype VIII Group B Streptococcal Infections in Denmark

Cited by 20 publications

References 18 publications

The Epidemiology of Invasive Group B Streptococcus in Denmark From 2005 to 2018

The Epidemiology of Invasive Group B Streptococcus in Denmark From 2005 to 2018

Invasive Group B Streptococcal Disease in Non-pregnant Adults

Perinatal Streptococcus agalactiae Epidemiology and Surveillance Targets

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