Emergence of Lipid Droplets in the Mechanisms of Carcinogenesis and Therapeutic Responses

Delmas, Dominique; Cotte, Alexia Karen; Connat, Jean‐Louis; Hermetet, François; Bouyer, Frédéric; Aires, Virginie

doi:10.3390/cancers15164100

Cited by 6 publications

(2 citation statements)

References 112 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, it has been hypothesized that LDs sequester anti-cancer drugs, hampering their efficacy. Moreover, since augmented LD biogenesis have been reported in different neoplastic conditions, this makes LDs novel suitable targets for anticancer drugs and for the development of new dyes for cancer cells imaging ( 36 , 37 ).…”

Section: Common Genetic Signature Between Masld-hcc and Lipid Disordersmentioning

confidence: 99%

Cardiometabolic risk factors in MASLD patients with HCC: the other side of the coin

Meroni,

Longo,

Dongiovanni

2024

Front. Endocrinol.

View full text Add to dashboard Cite

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) constitutes the commonest cause of chronic liver disorder worldwide, whereby affecting around one third of the global population. This clinical condition may evolve into Metabolic Dysfunction-Associated Steatohepatitis (MASH), fibrosis, cirrhosis and hepatocellular carcinoma (HCC), in a predisposed subgroup of patients. The complex pathogenesis of MASLD is severely entangled with obesity, dyslipidemia and type 2 diabetes (T2D), so far so nutritional and lifestyle recommendations may be crucial in influencing the risk of HCC and modifying its prognosis. However, the causative association between HCC onset and the presence of metabolic comorbidities is not completely clarified. Therefore, the present review aimed to summarize the main literature findings that correlate the presence of inherited or acquired hyperlipidemia and metabolic risk factors with the increased predisposition towards liver cancer in MASLD patients. Here, we gathered the evidence underlining the relationship between circulating/hepatic lipids, cardiovascular events, metabolic comorbidities and hepatocarcinogenesis. In addition, we reported previous studies supporting the impact of triglyceride and/or cholesterol accumulation in generating aberrancies in the intracellular membranes of organelles, oxidative stress, ATP depletion and hepatocyte degeneration, influencing the risk of HCC and its response to therapeutic approaches. Finally, our pursuit was to emphasize the link between HCC and the presence of cardiometabolic abnormalities in our large cohort of histologically-characterized patients affected by MASLD (n=1538), of whom 86 had MASLD-HCC by including unpublished data.

show abstract

Section: Common Genetic Signature Between Masld-hcc and Lipid Disordersmentioning

confidence: 99%

Cardiometabolic risk factors in MASLD patients with HCC: the other side of the coin

Meroni,

Longo,

Dongiovanni

2024

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…Lipid droplets (LDs) are ubiquitous dynamic organelles composed of a core of esterified neutral lipids, such as fatty acids (FAs), triacylglycerols (TAGs), cholesterol and other sterol esters, retinyl esters, and ceramides esterified into acyl ceramides, enclosed by a phospholipid monolayer enriched in several proteins and then packaged by intermediate filament vimentin [32][33][34][35][36][37][38].…”

Section: Physiological Roles Of Ldsmentioning

confidence: 99%

An Overview on Lipid Droplets Accumulation as Novel Target for Acute Myeloid Leukemia Therapy

Nisticò,

Chiarella

2023

Biomedicines

View full text Add to dashboard Cite

Metabolic reprogramming is a key alteration in tumorigenesis. In cancer cells, changes in metabolic fluxes are required to cope with large demands on ATP, NADPH, and NADH, as well as carbon skeletons. In particular, dysregulation in lipid metabolism ensures a great energy source for the cells and sustains cell membrane biogenesis and signaling molecules, which are necessary for tumor progression. Increased lipid uptake and synthesis results in intracellular lipid accumulation as lipid droplets (LDs), which in recent years have been considered hallmarks of malignancies. Here, we review current evidence implicating the biogenesis, composition, and functions of lipid droplets in acute myeloid leukemia (AML). This is an aggressive hematological neoplasm originating from the abnormal expansion of myeloid progenitor cells in bone marrow and blood and can be fatal within a few months without treatment. LD accumulation positively correlates with a poor prognosis in AML since it involves the activation of oncogenic signaling pathways and cross-talk between the tumor microenvironment and leukemic cells. Targeting altered LD production could represent a potential therapeutic strategy in AML. From this perspective, we discuss the main inhibitors tested in in vitro AML cell models to block LD formation, which is often associated with leukemia aggressiveness and which may find clinical application in the future.

show abstract

A Naphthalimide Based “Turn‐ON” Probe for Wash‐Free Imaging of Lipid‐Droplet in Living Cells With an Excellent Selectivity

Michel,

Durand,

Chevalier

2024

ChemBioChem

View full text Add to dashboard Cite

The impacts of dimethylation of 4‐Amino‐1,8‐ Naphthalimide (ANI) on its photophysical properties are reported. The resulting 4‐DiMe‐ANI displays completely different fluorescence properties, conferring it ability to selectively label lipid droplets in living cells. A comprehensive photophysical study revealed that this selectivity arises from an Internal Charge Transfer favored in lipophilic media to the detriment of a non‐emissive TICT in more polar media. This results in a very high "LDs/Cytosol" signal ratio, enabling LDs to be imaged with an excellent signal‐to‐noise ratio, and positioning its performance above that of the BODIPY 493/503 commonly used to image LDs.

show abstract

Emergence of Lipid Droplets in the Mechanisms of Carcinogenesis and Therapeutic Responses

Cited by 6 publications

References 112 publications

Cardiometabolic risk factors in MASLD patients with HCC: the other side of the coin

Cardiometabolic risk factors in MASLD patients with HCC: the other side of the coin

An Overview on Lipid Droplets Accumulation as Novel Target for Acute Myeloid Leukemia Therapy

A Naphthalimide Based “Turn‐ON” Probe for Wash‐Free Imaging of Lipid‐Droplet in Living Cells With an Excellent Selectivity

Contact Info

Product

Resources

About