Emergence of microfluidic devices in sample extraction; an overview of diverse methodologies, principals, and recent advancements

Alidoust, Mina; Baharfar, Mahroo; Manouchehri, Mahshid; Yamini, Yadollah; Tajik, Mohammad; Seidi, Shahram

doi:10.1016/j.trac.2021.116352

Cited by 39 publications

(14 citation statements)

References 179 publications

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“…The synthetic preparation of the polymer involves a multiple-stage process using the molecular imprinted polymer (MIP) method, a technique refined through specific steps including selection of target molecule and functional monomers, addition of initiators and cross-linkers, preparation of the molecular printing template, polymerization, template removal, cleaning, and characterization of the obtained polymer, and employing the obtained MIP for the recognition and extraction of the target molecule. Effective extraction techniques play a pivotal role in detecting biological analytes by facilitating the isolation and concentration of specific molecules from complex biological samples, thereby improving the precision and sensitivity of analytical methods. − Applications include chemical separation, drug delivery, or biosensors. ,− …”

Section: Introductionmentioning

confidence: 99%

Selective Extraction and Quantification of Hemoglobin Based on a Novel Molecularly Imprinted Nanopolymeric Structure of Poly(acrylamide-vinyl imidazole)

Şarkaya,

Özçelik,

Yaşar

et al. 2024

ACS Omega

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Imbalances in hemoglobin (Hb) levels can lead to conditions such as anemia or polycythemia, emphasizing the importance of precise Hb extraction from blood. To address this, a novel synthetic imprinted polymer was meticulously developed for capturing and separating Hb. Poly(acrylamide-vinylimidazole) nanopolymer (poly(AAm-VIM)) was synthesized using acrylamide and vinyl imidazole as functional monomers through surfactant-free emulsion polymerization. Characterization using FTIR, particle size, zeta potential, and SEM ensured the polymer's structure. The Hb-imprinted nanopolymer (Hbpoly(AAm-VIM)) demonstrated notable specificity, with a calculated Hb-specific adsorption value (Q max ) of 3.7377 mg/g in a medium containing 2.5 mg/mL Hb. The molecularly imprinted polymer (MIP) exhibited approximately 5 times higher Hb adsorption than the nonimprinted polymer (NIP). Under the same conditions, the imprinted nanopolymer displayed 2.39 and 2.17 times greater selectivity for Hb over competing proteins such as bovine serum albumin (BSA) and lysozyme (Lys), respectively. Also, SDS-PAGE analysis results confirmed the purification of Hb by the molecularly imprinted nanopolymer. These results underscore the heightened specificity and efficacy of the molecularly imprinted nanopolymer in selectively targeting Hb atoms among other proteins. Incorporating such polymers is justified by their notable affinity, cost-effectiveness, and facile production. This research contributes valuable insights into optimizing synthetic imprinted polymers for efficient Hb extraction, with potential in medical diagnostics and treatment applications.

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Section: Introductionmentioning

confidence: 99%

Selective Extraction and Quantification of Hemoglobin Based on a Novel Molecularly Imprinted Nanopolymeric Structure of Poly(acrylamide-vinyl imidazole)

Şarkaya,

Özçelik,

Yaşar

et al. 2024

ACS Omega

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“…Liquid–liquid extraction plays an important role in industrial applications. To improve the mass-transfer efficiency, miniaturized devices have been integrated with liquid–liquid extraction processes especially in biochemical processes, , pharmaceutical production, − and analytical chemistry, , for it could provide shorter mass-transfer lengths, larger interface areas, and low energy/material consumption. In 1996, Liu and Dasgupta developed a liquid-phase microextraction (LPME) system.…”

Section: Introductionmentioning

confidence: 99%

Continuous Counter-Current Multistage Microextraction in a Novel Tube-In-Tube Microextractor

Chen

Zhou

Xie

et al. 2023

Ind. Eng. Chem. Res.

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Counter-current operation has been widely applied to enhance the extraction efficiency for systems with low distribution coefficients, which was hindered in microextraction because viscous force and surface tension dominate over gravity and inertial force. In this study, a novel design of a tube-in-tube microextractor relying on a poly tetra fluoroethylene membrane to construct a stable interface was proposed to conduct continuous counter-current extraction. Extraction kinetics for two systems with different distribution coefficients, membranes with different pore radii, and three flow rate ratios were measured as a function of residence time. For the system that toluene was used to extract 0.06 wt % phenol in water, 4.1 stages of extraction efficiency were achieved at a residence time of 9.8 min. A challenging case study (50 wt % acetone−water−toluene) was subsequently conducted to prove the high applicability for emulsion systems of this special microextractor. Lastly, a mathematical model was established and the predicted results of three flow rate ratios are in good agreement with experimental results.

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“…Microfluidic devices have undergone significant improvements over the past decade, with advances in fabrication techniques, materials, integration, and applications [1]. These improvements have enabled the development of more advanced and sophisticated microfluidic devices, which are being used in a wide range of applications, including drug delivery [2], diagnostics [3], environmental monitoring [4,5], and biological sample analysis [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

An improved microfluidic device to enhance the enrichment factors in liquid phase microextraction: application to the simultaneous extraction of polar and non-polar acids in biological samples

et al. 2023

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A new microfluidic device to enhance the enrichment factor in miniaturized systems is proposed. The microfluidic system was design for liquid phase microextractions, and it was applied to the simultaneous extraction of acidic compounds of a wide range of polarity (0.5 < log P < 3). The device operated under stagnant acceptor phase conditions and all the operational parameters involved were optimized. Tributyl phosphate was found to be a new highly efficient supported liquid membrane to simultaneously extract analytes of very different polarities. The optimal donor and acceptor phase were pH 2 and pH 13, respectively. The donor flow rate and the extraction time were investigated simultaneously, offering great versatility with high enrichment factors (EFs). Limits of quantitation were within 0.02 and 0.09 µg mL−1 for all compounds at 10 µL min−1 as donor flow rate and 20-min extractions, offering EFs between 11 and 18 with only 200-µL sample volume consumption. The method was successfully applied to human urine samples, observing recoveries between 47 and 90% for all compounds. This new proposed microfluidic system increases the wide range of applications, especially when the analytes are present in lower concentrations in the sample. Graphical Abstract

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Emergence of microfluidic devices in sample extraction; an overview of diverse methodologies, principals, and recent advancements

Cited by 39 publications

References 179 publications

Selective Extraction and Quantification of Hemoglobin Based on a Novel Molecularly Imprinted Nanopolymeric Structure of Poly(acrylamide-vinyl imidazole)

Selective Extraction and Quantification of Hemoglobin Based on a Novel Molecularly Imprinted Nanopolymeric Structure of Poly(acrylamide-vinyl imidazole)

Continuous Counter-Current Multistage Microextraction in a Novel Tube-In-Tube Microextractor

An improved microfluidic device to enhance the enrichment factors in liquid phase microextraction: application to the simultaneous extraction of polar and non-polar acids in biological samples

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