Emergence of multidrug-resistant Acinetobacter baumannii under fluctuating levofloxacin concentration and its control by chlorine and UV disinfection

Zhang, Chi; Hao, Liting; Miao, Hanchen; Chen, Jiayu; Yuan, Tian; Lei, Zhongfang; Zhang, Zhenya; Utsumi, Motoo; Itayama, Tomoaki; Miura, Tetsuji; Ihara, Ikko; Maseda, Hideaki; Tabassum, Salma; Shimizu, Kazuya

doi:10.1016/j.psep.2023.03.010

Cited by 5 publications

(2 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings, combined with emerging data on inappropriate administration and toxicity, have limited its clinical utility (12). Zhang et al recommended combining levofloxacin with a bactericidal antibiotic like ampicillin and sulbactam to combat Acinetobacter resistance (23).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Levofloxacin Prescription Pattern Based on International Standards in a Tertiary Hospital in Iran

Moaref,

Izadpanah,

Kouti

2024

Ann Mil Health Sci Res

View full text Add to dashboard Cite

Background: The emergence of antibiotic-resistant bacteria poses a significant global concern. The improper use of antibiotics, identified as a leading contributor to this problem, is a widespread issue in medical centers worldwide. Objectives: This study aimed to investigate the utilization pattern of levofloxacin, a commonly prescribed antibiotic. Methods: We conducted a retrospective descriptive study in Ahvaz, Iran, focusing on patients who had received levofloxacin over a 6-month period. Data collection involved a questionnaire comprising patient demographic details, diagnosis information, details concerning levofloxacin administration, and outcomes, all extracted from the patients' medical records. During the assessment, we considered factors such as the correct dosage, frequency of administration, potential drug interactions, and adverse effects. Data analysis was performed using SPSS v. 20. Results: A total of 35 patients, with a mean age of 55.17 ± 20.36 years, received levofloxacin during the study period, and 48.6% of them were women. On average, each patient received 3.20 ± 2.85 grams of levofloxacin, with a minimum dose of 0.500 grams and a maximum of 11.50 grams. The average treatment duration was 3.813 ± 4.26 days. In only 8.6% of cases, the prescribed dosage was deemed inappropriate, while in 40% of cases, the duration of antibiotic use was found to be inadequate. Conclusions: The utilization of levofloxacin was deemed irrational in 40% of cases. Although the prescribed dosage for the respective diagnoses was generally accurate, the treatment duration was often incorrect, potentially contributing to antibiotic resistance.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of Levofloxacin Prescription Pattern Based on International Standards in a Tertiary Hospital in Iran

Moaref,

Izadpanah,

Kouti

2024

Ann Mil Health Sci Res

View full text Add to dashboard Cite

show abstract

“…Acinetobacter baumannii is a nosocomial pathogen that causes a wide range of infections, including skin and soft-tissue infections associated with trauma, urinary tract infection, pneumonia, meningitis, and septicemia [ 1 , 2 ]. This bacterium, previously regarded as a low-grade pathogen, has acquired resistance against most of the commonly used antibiotics, marking the emergence of multidrug resistance (MDR) strains [ 2 ]. Currently, polymyxins, long considered agents of last resort, have become the chosen antimicrobial treatment for managing infections caused by this bacterium [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

TonB-Dependent Receptor Protein Displayed on Spores of Bacillus subtilis Stimulates Protective Immune Responses against Acinetobacter baumannii

et al. 2023

View full text Add to dashboard Cite

The emergence of antibiotic-resistant Acinetobacter baumannii strains with limited treatment options has become a significant global health concern. Efforts to develop vaccines against the bacteria have centred on several potential protein targets, including the TonB-dependent receptors (TBDRs). In the present study, TBDRs from A. baumannii were displayed on the surface of Bacillus subtilis spores. The immunogenicity of the recombinant spores was evaluated in orally vaccinated mice. None of the immunized mice demonstrated signs of illness and were observed to be healthy throughout the study. Sera and the intestinal secretions from the recombinant spores-treated mice demonstrated mucosal and humoral antibody responses to the vaccine antigen. In addition, bactericidal activities of the sera against A. baumannii clinical isolates were demonstrated. These observations suggest that the B. subtilis spore-displayed TBDRs should be further explored as much-needed potential oral vaccine candidates against A. baumannii.

show abstract

Synthesis of activated carbon-supported nano copper oxide and its inactivation performance on Escherichia coli in water

Li,

Zuo,

Deng

et al. 2024

Chemical Engineering Journal

View full text Add to dashboard Cite

Emergence of multidrug-resistant Acinetobacter baumannii under fluctuating levofloxacin concentration and its control by chlorine and UV disinfection

Cited by 5 publications

References 49 publications

Evaluation of Levofloxacin Prescription Pattern Based on International Standards in a Tertiary Hospital in Iran

Evaluation of Levofloxacin Prescription Pattern Based on International Standards in a Tertiary Hospital in Iran

TonB-Dependent Receptor Protein Displayed on Spores of Bacillus subtilis Stimulates Protective Immune Responses against Acinetobacter baumannii

Synthesis of activated carbon-supported nano copper oxide and its inactivation performance on Escherichia coli in water

Contact Info

Product

Resources

About