Double-beta decays of 100 Mo from the 6.0195-year exposure of a 6.914 kg high-purity sample were recorded by the NEMO-3 experiment that searched for neutrinoless double-beta decays. These ultra-rare transitions to 100 Ru have a half-life of approximately 7 × 10 18 years, and have been used to conduct the first ever search for periodic variations of this decay mode. The Lomb-Scargle periodogram technique, and its error-weighted extension, were employed to look for periodic modulations of the half-life. Monte Carlo modeling was used to study the modulation sensitivity of the data over a broad range of amplitudes and frequencies. Data show no evidence of modulations with amplitude greater than 2.5% in the frequency range of 0.33225 y −1 to 365.25 y −1 .