Emergence of Natural Super-Disintegrnats in Oro-Dispersible Tablets: An Overview

Abstract

Orally disintegrating tablets (ODTs) are an emerging trend in novel drug delivery system and have received ever-increasing demand during the last few decades. ODTs are solid unit dosage forms, which disintegrates or dissolves rapidly in the mouth without chewing and water. This type of property in dosage form can be attained by addition of different excipients, in which disintegrants are the key adjuvant. In recent years, several newer agents have been developed known as super-disintegrants. Super-disintegrants are used to improve the efficacy of solid dosage form and influence the release rate of dosage form. Diverse categories of super-disintegrants are such as synthetic, semi-synthetic, natural and co-processed blends etc. These have been employed to develop effectual ODTs and to overcome the limitations of conventional tablet dosage forms. The plant derived natural super disintegrants comply with many requirements of pharmaceutical excipients as they are non-toxic, stable, easily available, associated with less regulatory issues as compared to their synthetic counterpart and inexpensive; also these can be easily modified into more polar form. This review discuss about the development of various kind of natural super-disintegrating agents, along with their role in the tablet disintegration and as potent candidate to be used in ODTs, which are being used in the formulation to provide the safer, effective drug delivery with patient compliance.

An overview on FDA-approved natural super disintegrants efficacy in a fast dissolving drug delivery system

“…Pectin is a complex heteropolysaccharide-based hydrophilic colloid. Due to its high swelling index and high solubility in biological fluids, mango peel pectin, on the other hand, cannot be used to anticipate the behavior of super disintegrants, but it can be used to manufacture oral dispersible tablets [12]. Mango peel pectin was discovered to be a good candidate for acting as a superdisintegrant by M Rishabha et al Although it is not as powerful as synthetic sodium starch glycolate, Because of its superior solubility and improved swelling index, it can be used to make rapid dissolving tablets [13].…”

Natural Superdisintegrants for the Formulation of Orally Disintegrating Tablets

“…Agar consists of polysaccharides such as agarose and agaropectin. Former one is the reason for gel strength, and high gel strength makes it as a disintegrant for the formulation of orally disintegrating tablets (8) .  Pectin from mango peel: Pectin, which is a hydrophilic colloid made up of a group of heteropolysaccharides.…”

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“…The selection of excipient depended upon the optimized design of a fast disintegrating tablet. Superdisintegrants not only break the tablet into granules but also disrupt the powder particle from which the granules were formed 5 . The Superdisintegrants are classified as two categories according to their availability Synthetic Superdisintegrants: These agents are used in fast dispersible tablet because tablet shows excellent disintegration, wetting, and other parameters.…”