Emergence of NDM-1 and OXA-72 producing Acinetobacter pittii clinical isolates in Lebanon

Atrouni, Ahmad Al; Joly-Guillou, Marie-Laure; Hamzé, Monzer; Kempf, Marie

doi:10.1016/j.nmni.2016.04.005

Cited by 12 publications

(7 citation statements)

References 10 publications

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“…As for non-A. baumannii strains, a single study reported the first detection of A. pittii harboring the blaNDM-1 or the blaOXA-72 gene from a hospital located in the north of Lebanon [23]. This study highlights the importance of non baumannii strains in the clinical settings as suggested by other worldwide studies.…”

Section: Epidemiology Of Carbapenem Resistant Acinetobacter Species Isupporting

confidence: 58%

“…Kanj et al associated Acinetobacter anitratus bacteremia to an early relapse of thrombotic thrombocytopenic purpura in a 58 years old male during plasma exchange therapy in 2003 [22]. On the other hand, A. pittii was detected in the urine culture of a four-month-old child as well as from febrile gastroenteritis infected patient [23].…”

Section: Acinetobacter Baumannii In Lebanon: a Real Threat Or An Overmentioning

confidence: 99%

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Acinetobacter spp in a Third World Country with Socio-economic and Immigrants Challenges

Dandachi¹,

Azar²,

Hamouch³

et al. 2019

J Infect Dev Ctries

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Introduction: In the last decade, Acinetobacter species have taken a major public health concern. This is mainly due the increased resistance to a wide range of antibiotics causing treatment challenges. In view of the constant population mobilization and the economic crisis that Lebanon is currently facing, it becomes a necessity to re-evaluate the real threat of Acinetobacter spp and its implication in the one health. Methodology: This review was conducted through the analysis of 45 research papers and reports pertaining to Acinetobacter spp performed in Lebanon. More than 82% of the papers consulted were published in international journals and more than 70 percent of them had received impact factor. Results: An in depth description of the involvement of this organism in human infection and its role as potential pathogen or simple colonizer was performed. In addition, the different aspects of resistance, mostly to carbapenems and colistin was studied and summarized. While in animals and environment, susceptible strains were mostly isolated, OXA-23/OXA-24 were predominant in humans. Recently, NDM-1 producing Acinetobacter spp was detected in a Syrian refugee which then was reported in Lebanese patients. The bacterial identification procedures are non-systematic and not always reliable in the Lebanese studies presenting sometimes discrepancies an inconsistency. Conclusion: Acinetobacter is commonly isolated Lebanon. In view of the spread of resistance among these isolated and their dissemination, Infection control measures attempting to control the spread of this genus in and outside hospitals are lacking and thus require more attention and stewardship activities.

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Section: Epidemiology Of Carbapenem Resistant Acinetobacter Species Isupporting

confidence: 58%

Section: Acinetobacter Baumannii In Lebanon: a Real Threat Or An Overmentioning

confidence: 99%

Acinetobacter spp in a Third World Country with Socio-economic and Immigrants Challenges

Dandachi¹,

Azar²,

Hamouch³

et al. 2019

J Infect Dev Ctries

View full text Add to dashboard Cite

show abstract

“…Moreover, the first description of a bla OXA-143-like strain is reported here, which was isolated in 2014 from a wound sample of a female patient admitted to TGH. Alarmingly, since the first description in Lebanon of a bla NDM-1 -positive A. baumannii 30 and Acinetobacter pittii, 31 four more isolates were found in this study.…”

Section: Discussionmentioning

confidence: 61%

Wide spread of OXA-23-producing carbapenem-resistant Acinetobacter baumannii belonging to clonal complex II in different hospitals in Lebanon

Atrouni

Hamzé

Jisr

et al. 2016

International Journal of Infectious Diseases

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“…In Lebanon, the bla OXA-72 was firstly described in A. calcoaceticus isolated from purchased vegetables in Beirut [28]. It is also found in A. pittii isolated from patients admitted to Lebanese hospital in North of Lebanon, in 2015 [29]. Moreover, Rafei et al reported that among 31 carbapenem-resistant strains collected from different hospitals in Beirut and Northern Lebanon, 28 isolates carried the bla OXA-23 gene, 1 strain the bla OXA-24 gene and 2 strains the bla OXA-58 gene [30].…”

Section: Discussionmentioning

confidence: 99%

Investigation of multidrug-resistant ST2 Acinetobacter baumannii isolated from Saint George hospital in Lebanon

et al. 2019

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BackgroundAcinetobacter baumannii is an opportunistic pathogen causing various nosocomial infections. The spread of multidrug-resistant A. baumannii is a major public health problem. The aim of this study was to investigate the molecular epidemiology and the genetic support of multidrug-resistant A. baumannii isolates collected from Saint-Georges Hospital in Lebanon.MethodsBetween January and August 2016, 31 A. baumannii isolates were collected from sputum samples of patients infected with ventilator-associated pneumonia (VAP) and treated with colistin-carbapenem combination therapy. Antibiotic susceptibility testing was performed using the disk diffusion method. Carbapenemases, extended spectrum β-lactamases encoding genes and mcr-1/2 genes were investigated by RT-PCR and standard PCR. The epidemiological relatedness of the strains was studied using MLST analysis.ResultsMost of the isolates exhibited multidrug-resistant phenotypes. All the isolates were carbapenem-resistant and among them, 30 carried the class D carbapenemase blaoxa-23 gene while one isolate carried blaoxa-72 gene. MLST results revealed three sequence types, namely ST2, ST699, and ST627. Isolates having ST2 were the most prevalent clone (29/31, 93.5%).ConclusionsThis study shows a nosocomial spread of multidrug-resistant A. baumannii ST2 having blaOXA-23 gene in Saint-George in Lebanon. Monitoring and control measures need to be adopted to avoid the spread of A. baumannii to patients.

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Emergence of NDM-1 and OXA-72 producing Acinetobacter pittii clinical isolates in Lebanon

Cited by 12 publications

References 10 publications

Acinetobacter spp in a Third World Country with Socio-economic and Immigrants Challenges

Acinetobacter spp in a Third World Country with Socio-economic and Immigrants Challenges

Wide spread of OXA-23-producing carbapenem-resistant Acinetobacter baumannii belonging to clonal complex II in different hospitals in Lebanon

Investigation of multidrug-resistant ST2 Acinetobacter baumannii isolated from Saint George hospital in Lebanon

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