Emergence of NDM-producing <i>Pseudomonas aeruginosa</i> among hospitalized patients and impact on antimicrobial therapy during the coronavirus disease 2019 (COVID-19) pandemic – EXPRESSION OF CONCERN

Perez, Leandro Reus Rodrigues; Carniel, Eliana; Narváez, Gabriel

doi:10.1017/ice.2022.212

Cited by 1 publication

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“…An important rise in the total P. aeruginosa strains sent to the reference laboratories (from 12 404 to 19 013, 65.3%) and a significant increase in bla NDM during the post-pandemic onset period were observed, with the DR rising from 1% in the pre-onset period to 7% in the post-onset period. Perez et al [ 45 ] also found NDM-producing P. aeruginosa in 27 of 156 (17.3%) patients during the COVID-19 pandemic.…”

Section: Discussionmentioning

confidence: 99%

A 7-Year Brazilian National Perspective on Plasmid-Mediated Carbapenem Resistance in Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii Complex and the Impact of the Coronavirus Disease 2019 Pandemic on Their Occurrence

Kiffer,

Rezende,

Costa-Nobre

et al. 2023

Clinical Infectious Diseases

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Background Carbapenemase production is a global public health threat. Antimicrobial resistance (AMR) data analysis is critical to public health policy. Here we analyzed carbapenemase detection trends using the AMR Brazilian Surveillance Network. Methods Carbapenemase detection data from Brazilian hospitals included in the public laboratory information system dataset were evaluated. The detection rate (DR) was defined as carbapenemase detected by gene tested per isolate per year. The temporal trends were estimated using the Prais–Winsten regression model. The impact of COVID-19 on carbapenemase genes in Brazil was determined for the period 2015–2022. Detection pre- (October 2017 to March 2020) and post-pandemic onset (April 2020 to September 2022) was compared using the χ2 test. Analyses were performed with Stata 17.0 (StataCorp, College Station, TX). Results 83 282 blaKPC and 86 038 blaNDM were tested for all microorganisms. Enterobacterales DR for blaKPC and blaNDM was 68.6% (41 301/60 205) and 14.4% (8377/58 172), respectively. P. aeruginosa DR for blaNDM was 2.5% (313/12 528). An annual percent increase for blaNDM of 41.1% was observed, and a decrease for blaKPC of −4.0% in Enterobacterales, and an annual increase for blaNDM of 71.6% and for blaKPC of 22.2% in P. aeruginosa. From 2020 to 2022, overall increases of 65.2% for Enterobacterales, 77.7% for ABC, and 61.3% for P. aeruginosa were observed in the total isolates. Conclusions This study shows the strengths of the AMR Brazilian Surveillance Network with robust data related to carbapenemases in Brazil and the impact of COVID-19 with a change in carbapenemase profiles with blaNDM rising over the years.

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Section: Discussionmentioning

confidence: 99%