Emergence of ON1 genotype of human respiratory syncytial virus subgroup A in China between 2011 and 2015

Song, Jun‐Ho; Zhang, Yan; Wang, Huiling; Shi, Jing; Sun, Liwei; Zhang, Xiaojie; Yang, Zifeng; Guan, Weijun; Zhang, Hong; Yu, Pengbo; Xie, Zhengde; Cui, Ai‐Li; Ng, Teresa I.; Xu, Wenbo

doi:10.1038/s41598-017-04824-0

Cited by 31 publications

(38 citation statements)

References 46 publications

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“…While most of Chinese viruses , European viruses and Indian surrounding viruses, which solely clustered in genotype C, D, and F, respectively, showing geographic distribution circumscribed characterization. This is similar to other EV, like EV-A71 1 , but different with respiratory viruses such as measles 43 , 44 and human respiratory syncytial viruses 45 , 46 , which spread globally and different genotypes distributed cross over with each other in phylogenetic tree, not much geographic distribution circumscribed characterization.…”

Section: Discussionsupporting

confidence: 64%

The emerging sub-genotype C2 of CoxsackievirusA10 Associated with Hand, Foot and Mouth Disease extensively circulating in mainland of China

Guo

Huang

et al. 2018

Sci Rep

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Coxsackievirus A10 (CV-A10) associated with Hand, foot, and mouth disease (HFMD) cases emerged increasingly in recent years. In this study, the samples from nation-wide HFMD surveillance, including 27 out of 31 provinces in China were investigated, and the continuous and extensive virological surveillance, covered 13 years, were conducted to provide a comprehensive molecular characterization analysis of CV-A10. 855 CV-A10 viruses (33 severe cases included), were isolated from HFMD children patients during 2009 to 2016 in China. 164 representative sequences from these viruses, together with 117 CV-A10 sequences downloaded from GenBank based on entire VP1 were recruited in this study. Two new genotypes (F and G) and two sub-genotypes (C1 and C2) were identified. Among 264 Chinese sequences, 9 of them were genotype B, 8 of them were C1, and the other (247) were C2, the predominant sub-genotype in China since 2012. Chinese C2 viruses showed obvious temporal characteristics and can be divided into 3 clusters (cluster 1~3). Cluster 3 viruses was circulating extensively during 2014 and 2016 with more severe cases. It is very necessary and important to continuously conduct the extensive virological surveillance for CV-A10, and further evolutionary studies will provide more evidence on its evolution and virulence.

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Section: Discussionsupporting

confidence: 64%

The emerging sub-genotype C2 of CoxsackievirusA10 Associated with Hand, Foot and Mouth Disease extensively circulating in mainland of China

Guo

Huang

et al. 2018

Sci Rep

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“…In a previous study, we found that HRSVB predominated between 2008 and 2010 in China while HRSVA predominated in 2010 and 2012, and both subgroups co-circulated in China till March 2014 18 . We also reported that the ON1 genotype became the predominant genotype of HRSVA circulating in China between 2013 and 2015.…”

Section: Introductionmentioning

confidence: 76%

“…Of these, 295 samples were identified as HRSVA and 360 were identified as HRSVB, and 1 sample was identified to be positive for both HRSVA and HRSVB. Analysis of the HRSVA sequences has been reported previously 18 . In this study, 361 HRSVB sequences, together with sequences from 2 HRSVB samples collected from Jilin in 1991, as well as sequences from 2 HRSVB samples collected from Beijing in 2004, were analyzed.…”

Section: Resultsmentioning

confidence: 99%

“…Although there were studies that investigated the clinical characteristics, circulation, and/or molecular epidemiology of HRSV infection in some regional areas within China 11 , 17 , 22 , 23 , 25 , there is almost no large-scale study that examined these topics for the whole country. We recently reported the circulating patterns of HRSVA and HRSVB, and the detailed molecular epidemiology of HRSVA throughout China from 2008 to 2015 18 . The present study provided an extensive epidemiological analysis of HRSVB infection as well as phylogenetic and evolutionary analysis of HRSVB genotypes circulating in 6 representative geographic regions in China from 1991 to 2014.…”

Section: Discussionmentioning

confidence: 99%

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Emergence of BA9 genotype of human respiratory syncytial virus subgroup B in China from 2006 to 2014

Song

Wang

Shi

et al. 2017

Sci Rep

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A study was conducted to investigate the circulation of HRSV subgroup B (HRSVB) in China in recent years. HRSVB sequences from 365 samples collected in 1991, 2004 and 2008–2014 in China, together with 332 Chinese HRSVB sequences obtained from GenBank were analyzed to determine the geographic and yearly distribution of HRSVB. Phylogenetic analysis revealed these HRSVB sequences clustered into 4 genotypes with different frequencies: BA (83%), CB1 (11%), SAB (3.0%) and GB3 (0.7%). Between 2005 and 2013, there was a co-circulation of BA and non-BA genotypes in China. Genotypes BA9 and BA10 were two of the main BA genotypes detected in this study. Genotype BA9 was first detected in China in 2006 and became the predominant HRSVB genotype circulating in China from 2008 to 2014. Three different lineages were detected for both genotypes BA9 and BA10. Time to the most recent common ancestor for genotypes BA9 and BA10 was estimated for years 1997 and 1996, respectively. Results of this study not only contribute to the understanding of the circulation pattern, but also the phylogenetic pattern and evolution of HRSVB in China from 1991 to 2014.

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“…Since 2014-2015 was also the highest epidemic year for RSV-A, it was deduced that before 2012, the prevalent RSV genotype was NA1 from Chongqing, but in 2014, due to staff turnover, a new Hong Kong strain of ON1 genotype was introduced (Song et al, 2017), evolved, and became the dominant strain. Furthermore, because the population lacked antibody protection, the new genotype spread rapidly and caused the high incidence of RSV-A in 2014-2015 in Guangzhou.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological characteristics and phylogenic analysis of human respiratory syncytial virus in patients with respiratory infections during 2011–2016 in southern China

Luo

Huang

Zhong

et al. 2020

International Journal of Infectious Diseases

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A B S T R A C TBackground: Human respiratory syncytial virus (RSV) is one of the most important pathogens that cause acute respiratory infections in children and immunocompromised adults. This work was conducted to understand the epidemiological and phylogenetic features of RSV in southern China during 2011-2016. Methods: A total of 16 024 nasopharyngeal swabs were collected from patients with respiratory infections in 14 hospitals, and screened for RSV and seven other respiratory viruses using real-time PCR. Six hundred and twenty-three RSV-positive samples from 13 hospitals were further analyzed for subtypes. G gene sequencing and phylogenetic analysis were performed based on 46 RSV-A and 15 RSV-B strains. Results: RSV was detected in 9.5% of the 16 024 specimens, the highest among the eight respiratory viruses screened. Most of these specimens came from inpatients and children under 3 years of age. The incidence of RSV-A (9.4%) was higher than that of RSV-B (4.4%) in children (<15 years), but not in adults (0.64% vs. 0.58%). A 2-year RSV-A dominance followed by a 1-year RSV-B dominance pattern was found. The co-detection rate of RSV was 25.1%. The main prevalent genotypes were NA1, ON1, and BA9. The prevalent RSV-A genotype in 2011-2012 was NA1, close to Chongqing and Brazil, but a new Hong Kong ON1 genotype was introduced and became the prevalent genotype in Guangzhou in 2014-2015. Deduced amino acid sequence analysis confirmed the ongoing evolution and a high selection pressure of RSV-A and B strains, especially in RSV-A ON1 and NA1 genotypes. Conclusions: This study demonstrated the molecular epidemiological characteristics of RSV in patients with respiratory infections in southern China.

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Emergence of ON1 genotype of human respiratory syncytial virus subgroup A in China between 2011 and 2015

Cited by 31 publications

References 46 publications

The emerging sub-genotype C2 of CoxsackievirusA10 Associated with Hand, Foot and Mouth Disease extensively circulating in mainland of China

The emerging sub-genotype C2 of CoxsackievirusA10 Associated with Hand, Foot and Mouth Disease extensively circulating in mainland of China

Emergence of BA9 genotype of human respiratory syncytial virus subgroup B in China from 2006 to 2014

Epidemiological characteristics and phylogenic analysis of human respiratory syncytial virus in patients with respiratory infections during 2011–2016 in southern China

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