2018
DOI: 10.1099/jmm.0.000685
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Emergence of resistance to ciprofloxacin in Neisseria meningitidis in Brazil

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Cited by 21 publications
(22 citation statements)
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“…Given these encouraging results for antibacterial activity against Acinetobacter spp., the safety and efficacy of robenidine could be further explored in animal models of Acinetobacter infection (Paluchowska et al, 2017; Gorla et al, 2018) prior to further clinical development. In addition, using an appropriate formulation can improve the potency and safety of robenidine as a novel treatment for infections caused by A. baumannii (Paluchowska et al, 2017; Gorla et al, 2018) and A. baumannii - calcoaceticus complex (Clark et al, 2016; Ozvatan et al, 2016), which are reported to be emerging pathogens worldwide (Gales et al, 2001). Our results show that EDTA would be a suitable adjuvant for topical delivery but not systemic use due to the high concentrations of Ca 2+ and Mg 2+ in blood, while PMBN does not have this limitation and could be included as a possible adjuvant in both topical and systemic Acinetobacter infection models.…”
Section: Discussionmentioning
confidence: 99%
“…Given these encouraging results for antibacterial activity against Acinetobacter spp., the safety and efficacy of robenidine could be further explored in animal models of Acinetobacter infection (Paluchowska et al, 2017; Gorla et al, 2018) prior to further clinical development. In addition, using an appropriate formulation can improve the potency and safety of robenidine as a novel treatment for infections caused by A. baumannii (Paluchowska et al, 2017; Gorla et al, 2018) and A. baumannii - calcoaceticus complex (Clark et al, 2016; Ozvatan et al, 2016), which are reported to be emerging pathogens worldwide (Gales et al, 2001). Our results show that EDTA would be a suitable adjuvant for topical delivery but not systemic use due to the high concentrations of Ca 2+ and Mg 2+ in blood, while PMBN does not have this limitation and could be included as a possible adjuvant in both topical and systemic Acinetobacter infection models.…”
Section: Discussionmentioning
confidence: 99%
“…109 A significant proportion of the pilgrims also have a low level of education or health literacy. 110 , 111 As mentioned previously, meningococcal vaccine uptake remains generally high among Hajj pilgrims, particularly in recent years; 60 however, there have been very low rates reported for pneumococcal vaccination (1.2-11.3%). 112 There is also a discrepancy between certified and self-reported vaccination, as the latter tends to be appreciably higher than rates confirmed through certification.…”
Section: The Hajjmentioning
confidence: 95%
“…58 , 59 Resistance to fluoroquinolones has been linked to mutations in the gyrA and parC genes in N. meningitidis isolates. 60 Owing to the spread of this clonal complex, there is the potential for the strain to reach sub-Saharan Africa. This, in turn, may pose issues in the Kingdom of Saudi Arabia where ciprofloxacin is used as a prophylactic treatment for people making the pilgrimage from the meningitis belt to Makkah (Mecca) during the Hajj.…”
Section: Antibiotic Resistancementioning
confidence: 99%
“…Furthermore, the presence of mutations conferring reduced susceptibility to these antimicrobials was uncovered [9] , [10] , [11] , [12] , [13] , [14] . To our knowledge, this is the first study to describe an N. gonorrhoeae isolate containing previously described fluoroquinolone and cefixime resistance mutations from the Republic of Georgia.…”
Section: Introductionmentioning
confidence: 99%