Emergence of rheumatoid arthritis following exposure to natalizumab

Su, Elaine; Novic, Josh; Han, May

doi:10.1016/j.msard.2020.101936

Cited by 6 publications

(3 citation statements)

References 9 publications

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“…There are several case reports describing an onset or exacerbation of RA in MS patients treated with natalizumab and interferons. 70 , 120 – 122 However, as discussed for PsO, these are single case reports and a general discontinuation of an already established MS therapy – after RA onset – should be carefully evaluated.…”

Section: Discussionmentioning

confidence: 99%

“… 66 Moreover, there have been several cases of MS patients who developed RA or experienced an onset or exacerbation of PsO on treatment with natalizumab. 67 – 70 Natalizumab has been shown to alter the composition of lymphocyte subpopulations in the peripheral blood, with especially CD8 + T and CD19 + B cells being increased. 71 These changes – in addition to the hampered migration of leukocytes across the blood–brain or blood–gut barrier – could shift the inflammatory response from the CNS towards other tissues (e.g.…”

Section: Monoclonal Antibodiesmentioning

confidence: 99%

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Treatment approaches to patients with multiple sclerosis and coexisting autoimmune disorders

Brummer

Ruck

Meuth

et al. 2021

Ther Adv Neurol Disord

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The past decades have yielded major therapeutic advances in many autoimmune conditions – such as multiple sclerosis (MS) – and thus ushered in a new era of more targeted and increasingly potent immunotherapies. Yet this growing arsenal of therapeutic immune interventions has also rendered therapy much more challenging for the attending physician, especially when treating patients with more than one autoimmune condition. Importantly, some therapeutic strategies are either approved for several autoimmune disorders or may be repurposed for other conditions, therefore opening new curative possibilities in related fields. In this article, we especially focus on frequent and therapeutically relevant concomitant autoimmune conditions faced by neurologists when treating patients with MS, namely psoriasis, rheumatoid arthritis and inflammatory bowel diseases. We provide an overview of the available disease-modifying therapies, highlight possible contraindications, show pathophysiological overlaps and finally present which therapeutics can be utilized as a combinatory treatment, in order to ‘kill two birds with one stone’.

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Section: Discussionmentioning

confidence: 99%

Section: Monoclonal Antibodiesmentioning

confidence: 99%

Treatment approaches to patients with multiple sclerosis and coexisting autoimmune disorders

Brummer

Ruck

Meuth

et al. 2021

Ther Adv Neurol Disord

View full text Add to dashboard Cite

show abstract

“…Multiple sclerosis (MS) is an inflammatory autoimmune disease in which the myelin sheath and spinal cord in the central nervous system are damaged, which can result in demyelination and axonal loss. Some studies have suggested that patients with multiple sclerosis have an increased risk of rheumatoid arthritis ( 12 – 14 ). IBD is a chronic non-specific inflammatory condition of the gastrointestinal tract.…”

Section: Introductionmentioning

confidence: 99%

Identifying shared genetic loci and common risk genes of rheumatoid arthritis associated with three autoimmune diseases based on large-scale cross-trait genome-wide association studies

Wen

2023

Front. Immunol.

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IntroductionSubstantial links between autoimmune diseases have been shown by an increasing number of studies, and one hypothesis for this comorbidity is that there is a common genetic cause.MethodsIn this paper, a large-scale cross-trait Genome-wide Association Studies (GWAS) was conducted to investigate the genetic overlap among rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease and type 1 diabetes.Results and discussionThrough the local genetic correlation analysis, 2 regions with locally significant genetic associations between rheumatoid arthritis and multiple sclerosis, and 4 regions with locally significant genetic associations between rheumatoid arthritis and type 1 diabetes were discovered. By cross-trait meta-analysis, 58 independent loci associated with rheumatoid arthritis and multiple sclerosis, 86 independent loci associated with rheumatoid arthritis and inflammatory bowel disease, and 107 independent loci associated with rheumatoid arthritis and type 1 diabetes were identified with genome-wide significance. In addition, 82 common risk genes were found through genetic identification. Based on gene set enrichment analysis, it was found that shared genes are enriched in exposed dermal system, calf, musculoskeletal, subcutaneous fat, thyroid and other tissues, and are also significantly enriched in 35 biological pathways. To verify the association between diseases, Mendelian randomized analysis was performed, which shows possible causal associations between rheumatoid arthritis and multiple sclerosis, and between rheumatoid arthritis and type 1 diabetes. The common genetic structure of rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease and type 1 diabetes was explored by these studies, and it is believed that this important discovery will lead to new ideas for clinical treatment.

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Exploring autoimmune endocrine diseases induced by monoclonal antibodies used as multiple sclerosis pharmacotherapy: a systematic review

Sahraian,

Emami,

Ataei

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Emergence of rheumatoid arthritis following exposure to natalizumab

Cited by 6 publications

References 9 publications

Treatment approaches to patients with multiple sclerosis and coexisting autoimmune disorders

Treatment approaches to patients with multiple sclerosis and coexisting autoimmune disorders

Identifying shared genetic loci and common risk genes of rheumatoid arthritis associated with three autoimmune diseases based on large-scale cross-trait genome-wide association studies

Exploring autoimmune endocrine diseases induced by monoclonal antibodies used as multiple sclerosis pharmacotherapy: a systematic review

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