Emergence of sequence type 11 Klebsiella pneumoniae coproducing NDM-1 and VIM-1 metallo-β-lactamases in a Greek hospital

Papagiannitsis, Costas C.; Malli, Ergina; Florou, Zoi; Sarrou, Styliani; Hrabák, Jaroslav; Mantzarlis, Konstantinos; Zakynthinos, Εpameinondas; Petinaki, Efthymia

doi:10.1016/j.diagmicrobio.2016.12.008

Cited by 19 publications

(13 citation statements)

References 16 publications

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“…Of two, 154 kb plasmids were found in transconjugant after conjugation and the plasmid harbouring the blaNDM-1 and blaVIM-1 belonged to the IncW type, which was different from previously replicon type reported in India. Recent studies from Greece demonstrated the coproduction of NDM-1 and VIM-1 in a K. pneumoniae [17]. While in our study, we found co-expression of blaNDM-1 with blaVIM-1 producing M. wisconsensis from neonate admitted in NICU of the north Indian hospital.…”

Section: Discussioncontrasting

confidence: 54%

Co-existence of blaNDM-1 and blaVIM-1 producing Moellerella wisconsensis in NICU of North Indian Hospital

Ahmad

Ali²,

Khan

2020

J Infect Dev Ctries

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Infections caused by carbapenemase-producing Enterobacteriaceae have become a major threat to public health, worldwide. Here we report clinically significant NDM-1 and VIM-1 producing Moellerella wisconsensis which has not yet been described in the literature; this is the first report of M. wisconsensis strain harbouring blaNDM-1 and blaVIM-1, recovered from the rectal swab of a low birth weight female child admitted in NICU of the north Indian tertiary care hospital. A plasmid of IncW incompatibility with size of 154 kb was observed in AK-92 strain.

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Section: Discussioncontrasting

confidence: 54%

Co-existence of blaNDM-1 and blaVIM-1 producing Moellerella wisconsensis in NICU of North Indian Hospital

Ahmad

Ali²,

Khan

2020

J Infect Dev Ctries

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“…The emergence of NDM-producing strains was reported in 2011 in the University Hospital of Ioannina (Epirus, Central Greece) [3]. Since then, sporadic cases have been observed in hospitals in Athens (Attica), Patras (Peloponnese, western Greece) and Larissa (Thessaly, central Greece), all belonging to multilocus sequence type (ST) 11 type [4][5][6]. The first OXA-48-like carbapenemase outbreak was detected in 2012 [7] and apart from single cases [8,9], no major epidemics have been recorded in Greece.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and resistance phenotypes of carbapenemase-producing Klebsiella pneumoniae in Greece, 2014 to 2016

et al. 2018

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“…3,4,14 However, very little information is available about CP C. freundii. 5,7,8 In addition, while some studies have described the co-production of two carbapenemases such as NDM-1 plus VIM-1 in C. freundii, K. pneumoniae and E. cloacae 17,18 or KPC-2 plus VIM-2 in K. pneumoniae, 19 very few studies have reported the co-production of VIM-1 plus OXA-48 17,20 and none of them in C. freundii. We detected a moderate increase in CP Citrobacter spp.…”

Section: Resultsmentioning

confidence: 99%

Carbapenem-resistant Citrobacter spp. isolated in Spain from 2013 to 2015 produced a variety of carbapenemases including VIM-1, OXA-48, KPC-2, NDM-1 and VIM-2

Arana

Ortega

González-Barberá

et al. 2017

Journal of Antimicrobial Chemotherapy

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Objectives There is little information about carbapenemase-producing (CP) Citrobacter spp. We studied the molecular epidemiology and microbiological features of CP Citrobacter spp. isolates collected in Spain (2013–15). Methods In total, 119 isolates suspected of being CP by the EUCAST screening cut-off values were analysed. Carbapenemases and ESBLs were characterized using PCR and sequencing. The genetic relationship among Citrobacter freundii isolates was studied by PFGE. Results Of the 119 isolates, 63 (52.9%) produced carbapenemases, of which 37 (58.7%) produced VIM-1, 20 (31.7%) produced OXA-48, 12 (19%) produced KPC-2, 2 (3.2%) produced NDM-1 and 1 (1.6%) produced VIM-2; 9 C. freundii isolates co-produced VIM-1 plus OXA-48. Fourteen isolates (22.2%) also carried ESBLs: 8 CTX-M-9 plus SHV-12, 2 CTX-M-9, 2 SHV-12 and 2 CTX-M-15. Fifty-seven isolates (90.5%) were C. freundii, 4 (6.3%) were Citrobacter koseri, 1 (1.6%) was Citrobacter amalonaticus and 1 (1.6%) was Citrobacter braakii. By EUCAST breakpoints, eight (12.7%) of the CP isolates were susceptible to the four carbapenems tested. In the 53 CP C. freundii analysed by PFGE, a total of 44 different band patterns were observed. Four PFGE clusters were identified: cluster 1 included eight isolates co-producing VIM-1 and OXA-48; blaVIM-1 was carried in a class 1 integron (intI–blaVIM-1–aacA4–dfrB1–aadA1–catB2–qacEΔ1/sul1) and blaOXA-48 was carried in a Tn1999.2 transposon. Conclusions We observed the clonal and polyclonal spread of CP Citrobacter spp. across several Spanish geographical areas. Four species of Citrobacter spp. produced up to five carbapenemase types, including co-production of VIM-1 plus OXA-48. Some CP Citrobacter spp. isolates were susceptible to the four carbapenems tested, a finding with potential clinical implications.

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Emergence of sequence type 11 Klebsiella pneumoniae coproducing NDM-1 and VIM-1 metallo-β-lactamases in a Greek hospital

Cited by 19 publications

References 16 publications

Co-existence of blaNDM-1 and blaVIM-1 producing Moellerella wisconsensis in NICU of North Indian Hospital

Co-existence of blaNDM-1 and blaVIM-1 producing Moellerella wisconsensis in NICU of North Indian Hospital

Epidemiology and resistance phenotypes of carbapenemase-producing Klebsiella pneumoniae in Greece, 2014 to 2016

Carbapenem-resistant Citrobacter spp. isolated in Spain from 2013 to 2015 produced a variety of carbapenemases including VIM-1, OXA-48, KPC-2, NDM-1 and VIM-2

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