Emergence of taurine as a therapeutic agent for neurological disorders

Abstract

Taurine is a sulfur-containing, semi-essential amino acid that occurs naturally in the body. It alternates between inflammation and oxidative stress-mediated injury in various disease models. As part of its limiting functions, taurine also modulates endoplasmic reticulum stress, Ca 2 + homeostasis, and neuronal activity at the molecular level. Taurine effectively protects against a number of neurological disorders, including stroke, epilepsy, cerebral ischemia, memory dysfunction, and spinal cord injury. Although various therapies are available, effective management of these disorders remains a global challenge. Approximately 30 million people are affected worldwide. The design of taurine formation could lead to potential drugs/supplements for the health maintenance and treatment of central nervous system disorders. The general neuroprotective effects of taurine and the various possible underlying mechanisms are discussed in this review. This article is a good resource for understanding the general effects of taurine on various diseases. Given the strong evidence for the neuropharmacological efficacy of taurine in various experimental paradigms, it is concluded that this molecule should be considered and further investigated as a potential candidate for neurotherapeutics, with emphasis on mechanism and clinical studies to determine efficacy.

Inhibition of hypoxia-inducible factors suppresses subretinal fibrosis

“…Taurine is a non-proteinogenic amino sulfonic acid widely distributed in animal tissues and naturally occurs in foods with protein, such as the meat of fish (60)(61)(62)(63). We previously found that marine products (especially, fish) could inhibit HIF activation in ocular cells in vitro and in vivo and further suppress retinal neovascularization in a neonatal murine model of OIR (18).…”

Pharmacophore-Based Screening, Molecular Docking, and Dynamic Simulation of Fungal Metabolites as Inhibitors of Multi-Targets in Neurodegenerative Disorders

“…In this explanation, the significance of the olive polyphenol modulation of Nrf2-related stress-responsive genes, which, in accordance with the hormesis theory, activate this neuroprotective cascade to maintain brain health, was highlighted, as well as offering potential application in the prevention and treatment of aging and age-related cognitive disorders in people [32,33]. Moreover, some other natural compounds, such as geraniol, soyasapogenol-B, taurine, and nobiletin, showed promising results for the management of neurological manifestations [13,30,34,35]. Similar to natural products, works have shown the therapeutic potential of the use of fungal metabolites against various disorders [36,37].…”

Lipid-Based Nano-Formulation Development to Enhance Oral Bioavailability of Weakly Aqueous-Soluble Drug for Obesity and Hypertension

“…Numerous therapeutic benefits of organic substances and nanoparticles have been described in the past to regulate the negative pathophysiological consequences associated with oxidative stress, infection by microbes, gastric ulcer, hypercholesterolemia, cancer and brain diseases [19][20][21][22][23][24][25][26][27][28][29] . Several reports suggested their beneficial role for neurological disorders, tumours, and other diseases [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47] .…”