Emergence of VIM metallo-β-lactamase among carbapenem-resistant Pseudomonas species in northwest Nigeria

Molecular detection of carbapenem resistant Klebsiella pneumoniae isolated from clinical specimens in Jos, Nigeria

“…Most of the K. pneumonia isolates were recovered from urine specimens 5(62.5%), followed by sputum samples 2(25.00%) and the lowest occurrence was in wounds swab 1(12.50%). This finding agrees with previous study by Olowo-okere et al [20] from Sokoto, Nigeria, where they isolated 292 Enterobacteriaceae including K. pneumoniae from clinical specimens and most were recovered from urine specimens [49.0%). Turugurwa et al [15] also reported highest (50.85%) Klebsiella recovery from urine samples irrespective of age and gender in Uganda.…”

“…Most studies in Nigeria have reported different carbapenem resistance genes from other Enterobacteriaceae. [20,27,28] reported blaNDM-5, blaOXA-48 and blaOXA-181 as the commonest carbapenemase genes in Nigeria. Our finding may however suggest that the resistance to meropenem could be due to other mechanisms such as efflux pump, decreased outer membrane permeability, porin loss or presence of β-lactams genes, as this was supported by previous studies where blaKPC was not detected in K. pneumoniae isolates [29,30].…”