ObjectiveTo evaluate differences in emergency department (ED) utilization and quality of care for migraine in patients with rural and nonrural residences.BackgroundMigraine is a significant problem in the United States with direct health‐care utilization cost amounting to US $4.2 billion annually. A considerable portion of this cost is attributed to more than 4 million annual ED visits for migraine and headache. Previous research has documented health disparities among rural populations in other disease states, which can be influenced by factors such as socioeconomic status and health‐care access. Given these associations, it was hypothesized that patients with rural residence in a national sample would have increased ED utilization for migraine compared to patients with nonrural residence.MethodsThis was a cross‐sectional epidemiologic study to evaluate rural disparities in ED utilization and quality of care for migraine in the United States in 2019. ED encounter data were collected from the Healthcare Cost and Utilization Project (HCUP) Nationwide Emergency Department Sample (NEDS) and Kentucky State Emergency Department Database (KY‐SEDD). The primary outcome was crude and age‐adjusted rates of ED encounters for migraine per 10,000 population. ED encounters were included if they had a primary International Classification of Diseases, Tenth Revision, Clinical Modification diagnosis code of G43.xx. ED encounters lacking sufficient data to classify into a geographic group were excluded. Secondary outcomes examined differences in quality of care, including mean ED charges and the proportion of encounters with medication administration, imaging, and nerve block service codes between groups.ResultsOne hundred eighty‐three thousand two hundred eleven national ED discharges were classified as rural patient encounters and 627,176 were classified as nonrural. The rural group had significantly higher crude and age‐adjusted rates of ED utilization for migraine (crude: rural 39.8, 95% confidence interval [CI] 36.9–42.7; nonrural 22.2, 95% CI 21–23.5 and age‐adjusted: rural 41.8, 95% CI 38.8–44.8; nonrural 23.4, 95% CI 22.1–24.7). Opioid utilization was higher in rural encounters (rural n = 26,764, 14.6%; nonrural n = 50,367, 8%; p < 0.001). A Kentucky sub‐analysis found 5210 ED discharges were classified as Appalachian and 12,551 as non‐Appalachian. The Appalachian group had significantly higher ED utilization rates for migraine compared to the non‐Appalachian and national rural groups (crude: Appalachian 44.9, 95% CI 43.7–46.2; age‐adjusted: Appalachian 47.4, 95% CI 46.1–48.8). The Kentucky Appalachian group also demonstrated significantly higher opioid analgesia use compared to the national rural group (Appalachian n = 1031, 19.8%; p < 0.001).ConclusionThis study suggests rural populations, particularly in Appalachia, may experience significantly higher ED utilization for migraine compared to nonrural patients. Moreover, rural populations were more likely to receive suboptimal migraine management with opioid analgesia. Multimodal health‐care interventions should be developed to improve access to outpatient migraine care and further investigate potential risk factors in the rural population. With high ED utilization, the Appalachian population may benefit most from such an intervention.