Emergency Endovascular Nanopharmacologic Treatment in Advanced Gynecological Cancers

Tinelli, Andrea; Prudenzano, R; Malvasi, Antonio; Santantonio, M.; Lorusso, Vito

doi:10.1111/igc.0b013e3181e4a68d

Cited by 9 publications

(6 citation statements)

References 10 publications

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“…Uterine artery embolization (UAE) is increasingly used in the management of a variety of obstetric and gynecologic disorders, including uterine leiomyomas [1], postpartum hemorrhage [2], adenomyosis [3], uterine arteriovenous malformations [4], and gynecologic malignancyÀrelated bleeding [5]. UAE is considered a nonsurgical minimally invasive management option for treating uterine myomas in poor surgical candidates and those who wish to avoid myomectomy or hysterectomy [6].…”

mentioning

confidence: 99%

Analysis of Reported Adverse Events with Uterine Artery Embolization for Leiomyomas

Armstrong

Kroener

Brower

et al. 2019

Journal of Minimally Invasive Gynecology

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The MAUDE database may be useful for clinicians using a Food and Drug Administration-approved medical device to identify the occurrence of adverse events and complications. A variety of adverse events associated with the use of uterine artery embolization were reported to the MAUDE database related to its use in the treatment of uterine myomas. We encourage physicians to review the MAUDE database when using medical devices, because this is an important tool to assess uncommon but major problems that could be associated with a medical device.

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mentioning

confidence: 99%

Analysis of Reported Adverse Events with Uterine Artery Embolization for Leiomyomas

Armstrong

Kroener

Brower

et al. 2019

Journal of Minimally Invasive Gynecology

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“…Несколько исследований было проведено для того, чтобы подчеркнуть положительную роль эмболизации доминантных артерий с целью остановки кровотечений [10,11]. J. M. Pisco и соавт.…”

Section: Discussionunclassified

Chemoembolization with HepaSpheres as a stage of comprehensive treatment for malignant pelvic tumors

Кедрова

Lebedev

Astakhov

et al. 2019

Opuholi ženskoj reproduktivnoj sistemy

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Genital bleeding poses a serious threat to patients with progressive locally advanced malignant tumors. Surgical treatment is often impossible in these patients; therefore, to achieve reliable hemostasis, the patients should undergo embolization of vessels feeding the tumor. Good results have been achieved by selective catheterization of pelvic arteries using chemoembolization with HepaSphere microspheres (Biosphere Medical, France) delivering the therapeutic agent to the tumor. Hydrophilicity of microspheres loaded with cytostatics and their biological compatibility with tissues ensure long-term therapeutic effect by controlling tumor growth. Pronounced hemostatic and antitumor effects of this treatment method have been confirmed by a morphological study. This study analyzes 38 patients that underwent chemoembolization with HepaSpheres loaded with doxorubicin or irinotecan, which allowed surgery and further treatment.

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“…Микросферы HepaSphere за счет своей гидрофильности и биологической совместимости с тканями позволяют депонировать химиопрепарат и достигать длительного лекарственного действия на опухоль [9]. Таким образом, метод ТАХЭ позволяет использовать 2 эффекта: остановку кровотечения и адресную доставку химиопрепарата для создания высокой концентрации лекарства в опухоли [10,11]. Сегодня технологический прогресс в эндоваскулярной хирургии позволяет осуществлять суперселективные воздействия на опухоль за счет разработки более совершенных микрокатетеров и гепасфер различного диаметра, насыщаемых доксорубицином или иринотеканом [9], что позволяет выбирать лекарственное средство в зависимости от типа опухоли.…”

Section: Introductionunclassified

Chemoembolization with HepaSpheres in the treatment of recurrent pelvic tumors

Кедрова¹,

Lebedev

Zvezdkina

et al. 2019

Opuholi ženskoj reproduktivnoj sistemy

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Transarterial chemoembolization of the main vessels feeding the tumor is a minimally invasive procedure, which is intended to block off the blood supply to the tumor and to deliver a cytotoxic agent to tumor cells. Initially, this method was used in emergency cases, but later it gained the trust of clinicians, who began to use it in non-emergency patients with clinical manifestations, when angiography showed well-supplied tumors inaccessible for ablation or surgical removal, including those in non-standard difficult cases. Selective catheterization of dominant arteries in recurrent tumors along with chemoembolization with drug-eluting microspheres is extremely challenging, since most of recurrent tumors have a well-developed neovascular network. HepaSphere microspheres, due to their hydrophilicity and high biological compatibility with tissues, allow the deposition of a chemotherapeutic agent in the tumor. This therapy provides pronounced hemostatic and antitumor effects confirmed by morphological and immunohistochemical examination. Currently, transarterial chemoembolization is mainly used for primary tumors and becomes increasingly popular as an element of combination therapy for patients with pelvic tumors. In this article, we analyze clinical data for 14 patients with recurrent pelvic tumors who underwent chemoembolization with HepaSpheres loaded with doxorubicin or irinotecan as a part of their palliative care.

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Emergency Endovascular Nanopharmacologic Treatment in Advanced Gynecological Cancers

Cited by 9 publications

References 10 publications

Analysis of Reported Adverse Events with Uterine Artery Embolization for Leiomyomas

Analysis of Reported Adverse Events with Uterine Artery Embolization for Leiomyomas

Chemoembolization with HepaSpheres as a stage of comprehensive treatment for malignant pelvic tumors

Chemoembolization with HepaSpheres in the treatment of recurrent pelvic tumors

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