Emergency presentation of cancer and short-term mortality

McPhail, Sean; Elliss‐Brookes, Lucy; Shelton, Jon; Ives, Alexander; Greenslade, M. Victoria; Vernon, Sally; Morris, Eva; Richards, Mike

doi:10.1038/bjc.2013.569

Cited by 185 publications

(203 citation statements)

References 31 publications

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“…However, due to the low coverage, low dependence, high specificity subjective judgment and the discomfort of the patients, the method is not widely used in the clinic (4)(5)(6)(7). The Thinprep liquid-based cytological test (TCT) provides the screening efficiency of cervical cytology with a better medium for cervical cells and avoidance of the disadvantages of the Pap smear test.…”

Section: Introductionmentioning

confidence: 99%

Epidemiological study of high‑risk human papillomavirus infection in subjects with abnormal cytological findings in cervical cancer screening

You

et al. 2017

Exp Ther Med

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Abstract. The present study aimed to determine the genotype and age distribution of high-risk human papillomavirus (HR-HPV) and evaluate HPV-DNA in subjects with abnormal cervical cytology results by using crowd-based cervical cancer screening cytology data. The Thinprep liquid-based cytologic test (TCT) was performed from January 2013 to January 2014 in the permanent residents of Liaocheng (China) aged 21-65 years who were married or had sexual intercourse. The number of screened women totaled 20,017, among whom 937 had abnormal results, 785 of which were recalled. For subjects in the age range of 21-65 years, an HR-HPV typing test using the fluorescence hybridization method. Among the 785 cases with abnormal TCT findings, repeated testing identified atypical squamous cells of unknown significance/atypical glandular cells in 478, low-grade squamous intraepithelial lesions in 175, high squamous intraepithelial lesions in 127 and squamous cell carcinoma/adenocarcinoma in 5 cases. Among these types, infection rates of HR-HPV were 50.2, 77.1, 89.0 and 100%, respectively. Of the 785 cases with abnormal TCT results, 493 (62.8%) were HR-HPV-positive. A total of 16 types of HR-HPV were detected: 68 and 73. Subjects infected with ≥2 types were defined as having a multi-type infection. The infection rate was high in the age groups of 26-30 and 51-55 years, accounting for 87.7% (71/81) and 79.7% (51/64), respectively, while it was lower in the >55 years group at 28.6% (14/54). The top five types of HR-HPV (stated in a decreasing order regarding positivity rate) were HPV16 (21.5%, 169/785), HPV52 (12.2%, 96/785), HPV58 (9.8%, 77/785), HPV33 (9.7%, 76/785) and HPV18 (7.5%, 59/785). Single-type infection was encountered in 45.0% (353/785) and multi-type infection in 17.8% (140/785), among which 98 cases had a two-type infection, 37 had a three-type infection, 2 had a four-type infection, 2 had a five-type infection and 1 case had a six-type infection. In the present study, differences in multi-type HR-HPV infection between groups with different TCT results were statistically significant. In conclusion, compared with CTC screening on its own, complementary HR-HPV testing is an effective method for screening for cervical cancer. The infection rate of HPV16, -52, -58, -33 and -18 was high among patients with cervical cytological abnormalities. Multi-type infection adds to the risk of malignancies. In Liaocheng, high-risk groups were aged 26-30 and 51-55. Attention should be paid during the screening and follow-up visits of these groups.

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Section: Introductionmentioning

confidence: 99%

Epidemiological study of high‑risk human papillomavirus infection in subjects with abnormal cytological findings in cervical cancer screening

You

et al. 2017

Exp Ther Med

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“…The survival of lung cancer patients presenting through an emergency route was examined separately for all non-resected lung cancer patients. Moreover, since previous studies have shown the largest differences in survival between groups of lung cancer patients in the first months after diagnosis [3,9], the association between emergency presentation and survival was investigated overall and for three time periods of follow-up.…”

Section: Introductionmentioning

confidence: 99%

The effect of emergency presentation on surgery and survival in lung cancer patients in England, 2006–2008

Tataru

Jack

Lind

et al. 2015

Cancer Epidemiology

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“…Emergency CRC surgery is a clinical challenges (18,19) that associated with advanced stage and high morbidity and mortality (20,21,22) and a high postoperative complications rate (10,23). Our study revealed that emergency CRC surgery is more worse outcomes than elective CRC surgery group in all stages.…”

Section: Discussionmentioning

confidence: 63%

The results of emergent curative surgery for the colorectal cancer; a single center experience of 52 patients

Öter¹,

Yalçın²,

Oter³

2018

J Turgut Ozal Med Cent

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Aim: Even though, protective methods and early diagnostic modalities are used in current practice, almost 6 to 30% of colorectal cancer patients admit to hospital for emergency operation with late complications. The aim of this study is to interpreting data of the early postoperative oncologic outcomes of the emergent curative CRC surgeries. Material and Methods: Between January 2012 and January 2017, 173 patients were operated curatively for colorectal cancer at Mehmet Akif İnan Training and Research Hospital of Health Sciences University. Of these, 52 patients were treated with emergent curative colorectal surgery. Demographics, laboratory, and clinical data, diagnostic studies, surgical procedures, operative findings, histopathologic results, postoperative complications, and patient follow-up were retrospectively analyzed. Results: The mean age (59.6 ± 10.9 vs. 57.7 ± 11.5, P = 0.98) and gender (71.15 vs. 76.03% male, P = 0.18) were close in emergent and elective colorectal cancer surgery groups. Early postoperative mortality was seen in 6 (11.5%) of those patients. The mean postoperative hospital stay in emergent surgery group was significantly longer than in elective surgery group. The 2-years overall survival rate of emergent and elective group were estimated 33 versus 77%, respectively. Conclusion: Our findings reveal that emergency CRC surgery predicts more advanced disease and longer operation time. Also in the emergent group have a higher complication rates, longer hospital stay, increased early postoperative morbidity, and lower long term survival in even all same stages.

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Emergency presentation of cancer and short-term mortality

Cited by 185 publications

References 31 publications

Epidemiological study of high‑risk human papillomavirus infection in subjects with abnormal cytological findings in cervical cancer screening

Epidemiological study of high‑risk human papillomavirus infection in subjects with abnormal cytological findings in cervical cancer screening

The effect of emergency presentation on surgery and survival in lung cancer patients in England, 2006–2008

The results of emergent curative surgery for the colorectal cancer; a single center experience of 52 patients

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