Based on the fuzzy uncertainty of assessment system, the fuzzy mathematics theory was applied to denote the groundwater health risk. On the basis of defining the parameters as triangular fuzzy numbers, uncertain models with triangular fuzzy parameters were established. As a case study, the fuzzy model was applied to evaluate the health risk of arsenic in groundwater in Tongyu County, Jilin Province. According to these calculations, interval values of health risk of arsenic under different confidence levels were obtained. The calculated results indicated that interval values of health risk of arsenic in phreatic water, confined water in Quaternary and Tertiary were equal to 2.43×10-5~105.74×10-5a-1, 3.45×10-5~98.444×10-5a-1 and 2.01×10-5~117.41×10-5a-1, and the most probable values were 23.72×10-5a-1, 63.53×10-5a-1 and 34.39×10-5a-1respectively. The assessment results showed groundwater in study area had great health risks and the fuzzy models more scientifically reveal the health risks state of hazardous substances in groundwater than the traditional ones.