Emergency Treatment of Seizures and Status Epilepticus

Is Tolerance to Antiepileptic Drugs Clinically Relevant?

“…Although tolerance to anesthetic effects does not necessarily parallel tolerance to antiepileptic activity, this observation does demonstrate the occurrence of some tolerance to pentobarbital during SE. Controlled studies of the role (if any) of contingent tolerance in the development of SE refractoriness could help in developing sorely needed evidence‐based guidelines for SE treatment (13,14).…”