Polarization state is an important characteristic of electromagnetic waves. The arbitrary control of the polarization state of such wave has atracted great interest in the scientiic community because of the wide range of modern optical applications that such control can aford. Recent advances in metamaterials provide an alternative method of realizing arbitrary manipulation of polarization state of electromagnetic waves in nanoscale via ultrathin, miniaturized, and easily integrable designs. In this chapter, we give a review of recent developments on polarization state manipulation of electromagnetic waves in metamaterials and discuss their applications in nanophotonics, such as polarization converter, wavefront controller, information coding, and so on.