Emerging Antimicrobial-Resistant Infections

Roos, Karen L.

doi:10.1001/archneur.61.10.1512

Cited by 7 publications

(5 citation statements)

References 20 publications

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“…Recently, many antimicrobials are at various stages of development and phases of clinical trials. However, it is still very clear that the discovery of new, potent antibacterial agents capable of overcoming drug resistance as well as the development of antibacterials with a new mechanism of action remains of the highest priority (Guardabassi and Kruse 2003;Ang et al 2004;Roos 2004;de Lima et al 2005;Al Ahmadi et al 2010;Perumal Samy et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial properties of snake venom components

Bocian

Hus

2019

Chem. Pap.

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An increasing problem in the field of health protection is the emergence of drug-resistant and multi-drug-resistant bacterial strains. They cause a number of infections, including hospital infections, which currently available antibiotics are unable to fight. Therefore, many studies are devoted to the search for new therapeutic agents with bactericidal and bacteriostatic properties. One of the latest concepts is to search for this type of substances among toxins produced by venomous animals. In this approach, however, special attention is paid to snake venom because it contains molecules with antibacterial properties. Thorough investigations have shown that the phospholipases A 2 (PLA 2) and l-amino acids oxidases (LAAO), as well as fragments of these enzymes, are mainly responsible for the bactericidal properties of snake venoms. Some preliminary research studies also suggest that fragments of three-finger toxins (3FTx) are bactericidal. It has also been proven that some snakes produce antibacterial peptides (AMP) homologous to human defensins and cathelicidins. The presence of these proteins and peptides means that snake venoms continue to be an interesting material for researchers and can be perceived as a promising source of antibacterial agents.

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Section: Introductionmentioning

confidence: 99%

Antibacterial properties of snake venom components

Bocian

Hus

2019

Chem. Pap.

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“…In fact, bacterial resistance has been the major factor responsible for increasing morbidity, mortality and health care costs of bacterial infections [1–5]. Therefore, new antimicrobials or antibacterial prototypes are continuously necessary for drug design and development for treatment of infections involving multidrug-resistant microorganisms [1, 2, 6, 7]. …”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Viperidae Venoms Antibacterial Profile: a Short Communication for Proteomics

Ferreira

Santos

et al. 2011

Evidence-Based Complementary and Alternative Medicine

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Bacterial infections involving multidrug-resistant strains are one of the ten leading causes of death and an important health problem in need for new antibacterial sources and agents. Herein, we tested and compared four snake venoms (Agkistrodon rhodostoma, Bothrops jararaca, B. atrox and Lachesis muta) against 10 Gram-positive and Gram-negative drug-resistant clinical bacteria strains to identify them as new sources of potential antibacterial molecules. Our data revealed that, as efficient as some antibiotics currently on the market (minimal inhibitory concentration (MIC) = 1–32 μg mL−1), A. rhodostoma and B. atrox venoms were active against Staphylococcus epidermidis and Enterococcus faecalis (MIC = 4.5 μg mL−1), while B. jararaca inhibited S. aureus growth (MIC = 13 μg ml−1). As genomic and proteomic technologies are improving and developing rapidly, our results suggested that A. rhodostoma, B. atrox and B. jararaca venoms and glands are feasible sources for searching antimicrobial prototypes for future design new antibiotics against drug-resistant clinical bacteria. They also point to an additional perspective to fully identify the pharmacological potential of these venoms by using different techniques.

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“…However, this worldwide problem may decrease if some attitudes can be adopted in a global perspective. Among them, the most important is still a reduction of the inappropriate and/or excessive use of antibiotics (132,133). …”

Section: Is There a Chance?mentioning

confidence: 99%

“…Despite reaching future positive statistics on antibiotic use, new antimicrobials will always be necessary to fight against multidrug-resistant microorganisms (132,133). Therefore, these drugs will be very important, particularly for treatment of the elderly, children and immune compromised patients (134–136).…”

Section: Is There a Chance?mentioning

confidence: 99%

Snake Venom: Any Clue for Antibiotics and CAM?

Lima

Abreu

Freitas

et al. 2005

Evidence-Based Complementary and Alternative Medicine

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Lately several naturally occurring peptides presenting antimicrobial activity have been described in the literature. However, snake venoms, which are an enormous source of peptides, have not been fully explored for searching such molecules. The aim of this work is to review the basis of antimicrobial mechanisms revealing snake venom as a feasible source for searching an antibiotic prototype. Therefore, it includes (i) a description of the constituents of the snake venoms involved in their main biological effects during the envenomation process; (ii) examples of snake venom molecules of commercial use; (iii) mechanisms of action of known antibiotics; and (iv) how the microorganisms can be resistant to antibiotics. This review also shows that snake venoms are not totally unexplored sources for antibiotics and complementary and alternative medicine (CAM).

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Emerging Antimicrobial-Resistant Infections

Cited by 7 publications

References 20 publications

Antibacterial properties of snake venom components

Antibacterial properties of snake venom components

Comparative Analysis of Viperidae Venoms Antibacterial Profile: a Short Communication for Proteomics

Snake Venom: Any Clue for Antibiotics and CAM?

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