Emerging Antineoplastic Plant-Based Gold Nanoparticle Synthesis: A Mechanistic Exploration of their Anticancer Activity Toward Cervical Cancer Cells

Khatua, Ashapurna; Prasad, Abhinav; Priyadarshini, Eepsita; Patel, Amiya Kumar; Naik, Aparupa; Saravanan, Muthupandian; Barabadi, Hamed; Ghosh, Indraneel; Paul, B; Paulraj, R; Meena, Ramovatar

doi:10.1007/s10876-019-01742-1

Cited by 69 publications

(20 citation statements)

References 38 publications

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“…Nanotechnology has shown an unprecedented impact on the pharmaceutical improvement due to the production of many nanomedicines that have the capacity to deliver the drug to the target position (3). Gold and silver metal nanoparticles have attracted much attention among all the high-precision nanomaterials because of their unique physiochemical properties which include antimicrobial activity (4,5), antivirus activity (6,7), antitumor activity (8)(9)(10), antifungal activity (11,12), antioxidant activity (13), antiparasitic activity (14), catalyst activity (15), and electronics property (16).…”

Section: Introductionmentioning

confidence: 99%

Green synthesis and characterizations of silver nanoparticles with enhanced antibacterial properties by secondary metabolites of Bacillus subtilis (SDUM301120)

et al. 2021

Green Chemistry Letters and Reviews

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Section: Introductionmentioning

confidence: 99%

Green synthesis and characterizations of silver nanoparticles with enhanced antibacterial properties by secondary metabolites of Bacillus subtilis (SDUM301120)

et al. 2021

Green Chemistry Letters and Reviews

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“…Nanoparticles are multidimensional materials that range from 1 to 100 nm in size (Ali, Qiang, Ilahi, Adnan, & Sajjad, 2018). Nanomaterials can be synthesized as, that is, chemically (Vasanth Patil et al, 2019), biologically using fungal species (Ghomi et al, 2019), and plant species (Khatua et al, 2020a). The physical synthesis of nanoparticles presents high energy consumption while the chemical production yields some toxic materials as byproducts (Behravan et al, 2019).…”

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confidence: 99%

Biological synthesis of silver nanoparticles using animal blood, their preventive efficiency of bacterial species, and ecotoxicity in common carp fish

Kakakhel

Feng

et al. 2021

Microscopy Res & Technique

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Possible high biodeterioration of the microorganisms due to their metabolic pathway and activities on stone materials causes solemn problems in cultural heritage. Different kinds of laboratory-scale methods have been used for the reduction of microbial growth, that is, chemical, mechanical, and physical, which are cost-effective and not ecofriendly. In the current study, an ecofriendly approach utilizing silver nanoparticles were synthesized using sheep blood serum. Transmission electron microscopy results have confirmed the spherical and well dispersed silver nanoparticles with an average size of 32.49 nm, while energy dispersive X-ray has shown the abundance of silver nanoparticles. The efficiency against bacterial species was verified through laboratory-scale testing. The strong antibacterial activity was confirmed when B-AgNPs was tested against different bacterial species isolated from the Beishiku Cave Temple. The largest zone of inhibition was measured 26.48 ± 0.14 mm against Sphingomonas sp. while the smallest zone of inhibition measured was 9.70 ± 0.27 mm against Massilia sp. Moreover, these ecofriendly B-AgNPs were tested for daily based dose in different concentrations (0.03, 0.06, and 0.09 mg/L) against common carp fish for a long exposure (20 days) and 6.5% fatality was found. The highest lethal concentration (LC 50 ) for fish (0.61 ± 0.09 mg/L). No doubt, the laboratory scale applications have revealed the best results with minute toxicity in fish. Therefore, sheep serum should be continued to synthesize silver nanoparticles on a large scale. A strict monitoring system should be developed for the synthesis and application of AgNPs.

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“…For example, a number of reports show that green synthesized nanoparticles could fight various types of cancer. 40 , 75–77 However, the biological activity of nanoparticles depends on many factors, such as size, shape, capping agent, etc. 78 , 79 The presence of plant extract derived capping agents in the nanoparticles may reduce their non-specific toxic behavior.…”

Section: Medicinal Plants and Metals In Green Synthesis Of Nanoparticlesmentioning

confidence: 99%

Prospective Application of Nanoparticles Green Synthesized Using Medicinal Plant Extracts as Novel Nanomedicines

Selvakesavan

Franklin

2021

NSA

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The use of medicinal plants in green synthesis of metal nanoparticles is increasing day by day. A simple search for the keywords “green synthesis” and “nanoparticles” yields more than 33,000 articles in Scopus. As of August 10, 2021, more than 4000 articles have been published in 2021 alone. Besides demonstrating the ease and environmental-friendly route of synthesizing nanomaterials, many studies report the superior pharmacological properties of green synthesized nanoparticles compared to those synthesized by other methods. This is probably due to the fact that bioactive molecules are entrapped on the surface of these nanoparticles. On the other hand, recent studies have confirmed the nano-dimension and biocompatibility of metal ash ( Bhasma ) preparations, which are commonly macerated with biological products and administered for the treatment of various diseases in Indian medicine since ancient times. This perspective article argues for the prospective medical application of green nanoparticles in the light of Bhasma .

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Emerging Antineoplastic Plant-Based Gold Nanoparticle Synthesis: A Mechanistic Exploration of their Anticancer Activity Toward Cervical Cancer Cells

Cited by 69 publications

References 38 publications

Green synthesis and characterizations of silver nanoparticles with enhanced antibacterial properties by secondary metabolites of Bacillus subtilis (SDUM301120)

Green synthesis and characterizations of silver nanoparticles with enhanced antibacterial properties by secondary metabolites of Bacillus subtilis (SDUM301120)

Biological synthesis of silver nanoparticles using animal blood, their preventive efficiency of bacterial species, and ecotoxicity in common carp fish

Prospective Application of Nanoparticles Green Synthesized Using Medicinal Plant Extracts as Novel Nanomedicines

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