Emerging application of extraction phase of ionic and non-ionic deep eutectic solvents toward natural herbal medicine

A Sustainable Extraction Approach of Phytochemicals from Date (Phoenix dactylifera L.) Fruit Cultivars Using Ultrasound-Assisted Deep Eutectic Solvent: A Comprehensive Study on Bioactivity and Phenolic Variability

“…Recently, studies have been published on extracting phenolic compounds from diverse biomass sources and botanical sources using the DES technique [17,[24][25][26][27]. As far as we are aware, there are currently no published studies that examine the retrieval of phenolic compounds from date fruits using the UA-NADES method.…”

Green and highly effective extraction of bioactive flavonoids from Fructus aurantii employing deep eutectic solvents-based ultrasonic-assisted extraction protocol

“…Deep eutectic solvents (DESs), a breakthrough environmentally benign solvent that has the potential to replace organic solvents, have been receiving considerable attention in recent years [11] , [12] , [13] . Usually, hydrogen bond donors (HBDs) and acceptors (HBAs) are combined and heated in the proper mole ratio to create DESs, which then react based on hydrogen bond interaction [11] , [12] , [13] , [14] , [15] .…”

“…Deep eutectic solvents (DESs), a breakthrough environmentally benign solvent that has the potential to replace organic solvents, have been receiving considerable attention in recent years [11] , [12] , [13] . Usually, hydrogen bond donors (HBDs) and acceptors (HBAs) are combined and heated in the proper mole ratio to create DESs, which then react based on hydrogen bond interaction [11] , [12] , [13] , [14] , [15] . In comparison with conventional organic solvents, DESs are not only non-toxicity, inexpensive in cost, environmental friendliness, biodegradable, nonflammable and stable, but they also have a series of benefits including quick and easy synthesis, availability and high-efficiency [16] , [17] , [18] , [19] , [20] , [21] , [22] .…”