In Minimum Quantity Lubrication (MQL) very small amount of cutting fluids are used. Currently, nanoparticles are added into cutting fluids to magnify the cooling and lubricating properties. Several studies are available on MQL to check the machining performance in terms of cooling and lubrication using nanofluids like Ag, SiO2, MoS2, Al2O3, Cu and MWCNT. However, limited evidences are available in applying hybrid nanoparticles in machining processes. Present research investigates the effect of hybridization of two different nanofluids on machining performance in turning operation of Ti-6Al-4V alloy. Moreover, machineability was evaluated and analyzed by performing turning using minimum quantity lubrication (MQL) cooling technique. Cutting temperature and surface roughness of machined surface were taken as technological performance parameters to evaluate the machinability of Ti-6Al-4V alloy. Hybridization was performed by mixing alumina based nanofluid into graphene nanoparticles in a fixed volumetric proportion 80:20 using vegetable oil as base fluid. Additionally, machining performance was evaluated by preparing hybrid nanofluid in different concentrations like (0.25,0.50,0.75 and 1.00vol%) and tested for thermophysical properties before experimentation. Significant improvements in thermophysical properties were observed during hybridization of Al2O3 and Graphene. For parametric optimization and design of experiment, Taguchi orthogonal array has been employed. Machining performance of vegetable oil base alumina-graphene hybrid nanofluid was compared with monotype alumina based nanofluid and a significant reduction cutting temperature and surface roughness was observed respectively.